nutraMetrix Isotonix® Peak Performance Blend - Single Bottle (30 Servings)

nutraMetrix Isotonix Peak Performance Blend is exactly what your body needs to preserve your muscles with essential nutrients, keep your body’s defenses up with powerful antioxidants, and provide you with a huge boost of energy from great vitamins. Performance, defense, energy – everything you need to be a true champion.

Performance is the key measure of success, which is why nutraMetrix Isotonix Peak Performance Blend is formulated to help benefit the performance of active adults with Instantized Branch Chain Amino Acids. Being both instantized and isotonic, you’re getting a product with superior bioavailability, allowing for faster absorption.

To defend your body from ongoing wear and tear, nutraMetrix Isotonix Peak Performance Blend provides an array of antioxidant benefits, thanks to the inclusion of Pycnogenol® - the isotonic form of which is exclusive worldwide to Market America – to help combat many aggressive free radicals before they cause oxidative stress to the body.

Finally, you need enough energy to not only compete, but to train. By including the activated forms of B vitamins – which are more readily processed by the body - their effectiveness is increased, which means you receive all their energy benefits. And, thanks to the utilization of the most advanced nutrient delivery system available anywhere – Isotonix® - you can be sure your body is getting the best – rapid absorption, no binders or fillers, and maximum results. It all adds up to an unmatched product for the person looking to raise their performance to the next level – nutraMetrix Isotonix Peak Performance Blend.

Pycnogenol® is a registered trademark of Horphag Research Ltd.

• Promotes healthy muscle growth and muscle retention
• Helps reduce occasional muscle fatigue
• Supports bone health
• Provides antioxidant protection to minimize the effects of free radicals
• Contains activated forms of select B vitamins to promote optimal utilization by the body
• Increases energy
• Promotes cardiovascular health
• Helps decrease stress and improve mood
• Helps maintain healthy levels of serotonin
• Promotes optimal immune functions
• Gluten-Free
• No Detectable GMOs
• Vegetarian

Isotonix - The World's Most Advanced Nutraceuticals

Isotonic, which means “same pressure,” bears the same chemical resemblance of the body’s blood, plasma and tears. All fluids in the body have a certain concentration, referred to as osmotic pressure. The body’s common osmotic pressure, which is isotonic, allows a consistent maintenance of body tissues. In order for a substance to be absorbed and used in the body’s metabolism, it must be transported in an isotonic state.

Isotonix dietary supplements are delivered in an isotonic solution. This means that the body has less work to do in obtaining maximum absorption. The isotonic state of the suspension allows nutrients to pass directly into the small intestine and be rapidly absorbed into the bloodstream.With Isotonix products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results.

Congratulations on taking steps to better health and well being! Here are a few tips on how to take your nutraMetrix Isotonix products, and the best way to store your products for maximum benefits. Always follow the directions for use as indicated on the label of the bottle, unless otherwise instructed by your health professional.

Pycnogenol®: 25 mg
Pycnogenol is a natural plant extract from the bark of the maritime pine tree, which grows exclusively along the coast of southwest France in Les Landes de Gascogne. This unspoiled and natural forest environment is the unique source of pine bark. Pycnogenol is one of the most researched ingredients in the natural product marketplace. Published findings have demonstrated Pycnogenol’s wide array of support to the body. Pine bark extract is an all-natural combination of procyanidins, bioflavonoids and organic acids. The extract has three basic properties — it is a powerful antioxidant, selectively binds to collagen and elastin, and promotes the normal production of endothelial nitric oxide, which promotes the normal dilation of blood vessels. As one of the most powerful natural scavengers of free radicals, Pycnogenol combats free radicals before they cause oxidative stress to vital organs. Its super-antioxidant capabilities promote cardiovascular health*

Instantized Branch Chain Amino Acids (IBCAAs): 3 g
Branched chain amino acids (BCAA) are considered essential, as they cannot be synthesized by the human body and, therefore, must be consumed through diet or supplementation. Unlike other amino acids, BCAA are used primarily by skeletal muscle, making up 30-35 percent of the muscle tissue itself. These amino acids promote healthy muscle growth and retention. As aging occurs, the body’s ability to build and retain muscle tissue or size is reduced, which can result in weakness and frailty. Research has shown that supplementation with BCAA promotes muscle retention in older adults. Additionally, it has been shown that supplementation of BCAA during exercise supports muscle protein synthesis and inhibits protein catabolism (breakdown) and muscle fatigue. By using instantized BCAAs within the isotonic system, there is a quicker dissolution and increased bioavailability.*

Activated B Vitamins (Folinic Acid, Methylcobalamin and Pyridoxal 5’ Phosphate)
B vitamins support numerous metabolic processes in the body. This formula contains the activated forms of select B vitamins to promote optimal use by the body. By using these advanced forms, the body has to work less for utilization and effectiveness is increased. Folinic acid, methylcobalamin (B12) and pyridoxal 5’ phosphate (B6) are known to promote cardiovascular health. Additional B vitamins such as B1, B5, niacin and biotin support many processes allowing this product to work via several mechanisms to increase energy, promote cardiovascular health, decrease stress and improve mood while helping to maintain normal serotonin levels.*

Vitamin C: 60 mg
Vitamin C is a multi-faceted nutrient primarily known for its antioxidant benefits and strong role in immune health. Vitamin C helps support cardiovascular health in a few different ways. It assists in promoting normal levels of cholesterol and normal blood pressure and promotes normal platelet activity. Vitamin C protects against LDL peroxidation by scavenging free radicals. Vitamin C helps maintain endothelial cell function by promoting the synthesis of nitric oxide (also known as NO and EDRF for endothelium-derived relaxing factor). Vitamin C may promote normal modulation of prostaglandin synthesis, which in turn promotes normal vasodilatory activity. As observed above, vitamin C helps maintain nitric oxide levels and supports its ability to preserve the integrity of the blood vessels. There is an indication that vitamin C supports endothelial-dependent vasodilation. Vitamin C plays a crucial role in maintaining healthy connective tissues including collagen, elastin, fibronectin, proteoglycans, bone matrix and elastin-associated fibrillin. Also, a lack of vitamin C can cause general fatigue. Next, vitamin C helps moderate healthy iron absorption, transport and storage. It promotes the normal intestinal absorption of iron.

Vitamin D3: 400 IU
Vitamin D is a fat-soluble vitamin that is found in some foods and endogenously produced when sunlight strikes the skin and activates vitamin D synthesis. Vitamin D promotes the efficient intestinal absorption of calcium, by supporting the synthesis of calcium-binding proteins to promote normal calcium absorption and retention. Vitamin D also promotes the normal formation of bone and normal bone growth, and bone remodeling by osteoblasts and osteoclasts. Vitamin D deficiency can be caused by factors such as lack of exposure to sunlight, reduced skin synthesis of vitamin D, lower dietary intake, impaired intestinal absorption, and reduced metabolism to active forms of vitamin D by the kidneys, all of which increase with aging. Deficiency has been linked to numerous health concerns and insufficient levels of this vitamin are associated with weak bones and muscle weakness. In addition to promoting strong bones, vitamin D also has other roles in health, including supporting the body’s immune function. Vitamin D has been shown to support normal immune-modulation, and it is thought that supplementation promotes immune health by promoting the body’s normal regulation of T-cell function. In reference to cellular health, vitamin D supports the modulation of many genes that are responsible for encoding proteins that regulate normal cell cycle activity. Vitamin D levels have been strongly correlated to healthy cells. Lastly, through its interaction with VDR (vitamin D receptor), vitamin D supports the healthy expression of the gene encoding renin, thus helping to maintain healthy blood pressure.

Should this product be taken on an empty stomach?  Yes. Maximum absorption occurs when taken on an empty stomach.

I am healthy and athletic. Why should I take nutraMetrix Isotonix® Peak Performance Blend?  Everyone is vulnerable to the aging process caused by free radicals. Athletes tend to be exposed to elevated levels of oxidative stress. Free radicals develop as byproducts during metabolism when calories are processed with oxygen. Athletes inhale 10 to 20 times more oxygen during physical activity over rest periods. The increase in activity creates additional free radicals. In fact, these free radicals are known to limit performance, as free radicals appear to take their toll on muscle tissue. Not only does Isotonix Peak Performance Blend help defend your body against free radicals, thanks to Pycnogenol ® , but the inclusion of Instantized Branch Chain Amino Acids can help reduce muscle fatigue, allowing for better workouts.*

What does “Activated” refer to in reference to B-vitamins?  Activated refers to the active forms of vitamins B6, B12 and folic acid. Using forms other than these activated forms requires that the vitamins be enzymatically activated prior to utilization by the body. Not only does this take time and energy within the body, there are circumstances in which this reaction is either slowed or inhibited.*

• Shimomura, Y., et al. Nutraceutical effects of branched-chain amino acids on skeletal muscle. Journal of Nutrition. 116(2): 529S-532S, 2006.
• Shimomura, Y., et al. Exercise promotes BCAA catabolism: effects of BCAA supplementation on skeletal muscle during exercise. Journal of Nutrition. 134(6):1583S-1587S, 2004.
• Volpi, E., et al. Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults. American Journal of Clinical Nutrition. 78: 250-258, 2003.
• Kimball SR and Jefferson LS. Control of protein synthesis by amino acid availability. Curr Opin Clin Nutr Metab Care. 5:63-7, 2002.
• Layman DK. The role of leucine in weight loss diets and glucose homeostasis. J Nutr. 133:261S-7S, 2003.
• Hutson SM and Harris RA. Introduction. Symposium: Leucine as a nutritional signal. J Nutr 131:839S-40S, 2001.
• Anthony JC, Anthony TG, Kimball SR, Jefferson LS. Signaling pathways involved in translational control of protein synthesis in skeletal muscle by leucine. J Nutr. 131:856S-60S, 2001.
• MacLean DA and Graham TE. Branched-chain amino acid supplementation augments plasma ammonia responses during exercise in humans. J Appl Physiol. 74:2711-7, 1993.
• MacLean DA and Graham TE, Saltin B. Branched-chain amino acids augment ammonia metabolism while attenuating protein breakdown during exercise. Am J Physiol. 267:E1010-22, 1994.
• Blomstrand E et al. Influence of ingesting a solution of branched-chain amino acids on plasma and muscle concentrations of amino acids during prolonged submaximal exercise. Nutrition. 12:485-90, 1996.
• Blomstrand, E., et al. Branched-chain amino acids activate key enzymes in protein synthesis after physical exercise. Journal of Nutrition. 136(1):269S-273S, 2006.
• Grant W and Holick M. Benefits and requirements of vitamin D for optimal health. Alternative Medicine Review. 10:94-111, 2005.
• Fine, AM. Oligomeric proanthocyanidin complexes: history, structure, and phytopharmaceutical applications. Altern Med Rev 5:144-51, 2000.
• Packer, L. et al. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 27:704-24, 1999. Review.
• Litoff, D., et al. Effects of pantothenic acid supplementation on human exercise. Med Sci Sport Exercise., 17(Supplement):287, 1985.
• Mittleman, K. D., et al. Branched-chain amino acids prolong exercise during heat stress in men and women. Med Sci Sports Exerc. 30(1):83-91, 1998.
  
• Newsholme, E. A., et al. Branched-chain amino acids and central fatigue. Journal of Nutrition. 136(1):274S-276S, 2006.
• Davis, J. M. Carbohydrates, branched-chain amino acids, and endurance: the central fatigue hypothesis. Int J Sport Nutr. 5(Supplement):S29-S38, 1995.
• Wald DS, Bishop L, Wald NJ, et al. Randomized trial of folic acid supplementation and serum homocysteine levels. Arch Intern Med 61:695-700, 2001.
• Bronstrup A, Hages M, Prinz-Langenohl R, Pietrzik K. Effects of folic acid and combinations of folic acid and vitamin B12 on plasma homocysteine concentrations in healthy young women. Am J Clin Nutr 68:1104-10, 1998.
• van Oort FV, Melse-Boonstra A, Brouwer IA, et al. Folic acid and reduction of plasma homocysteine concentrations in older adults: a dose-response study. 77:1318-23, 2003.
• Watson, R. Pycnogenol® and cardiovascular health. Evidence-Based Integrative Medicine 1: 27-32, 2003.
• Kelly, G. S. Nutritional and botanical interventions to assist with the adaptation to stress. Alternative Medicine Review.4(4):249-265, 1999.
• Benton D., et al. Thiamine supplementation for mood and cognitive functioning. Psychopharmacology. 129(1):66-71, 1997.
• Benton, D., et al. The effects of nutrients on mood. Public Health Nutr. 2(3A):403-409, 1999.
• Hartvig, P., et al. Pyridoxine effect on synthesis rate of serotonin in the monkey brain measured with position emission tomography. Neural Trans. 102:91-97, 1995.
• Deluca H et al. Vitamin D: its role and uses in immunology. FASEB Journal. 15(14):2579-2585, 2001.
• Hayes C et al. The immunological functions of the vitamin D endocrine system. Cellular and Molecular Biology. 49(2):277-300, 2003.
  
• Lenton, Kevin J., et al. Vitamin C augments lymphocyte glutathione in subjects with ascorbate deficiency. Am. J. Clinical Nutrition. 77: 189 – 195, 2003.