nutraMetrix OPC-3® Skin Health Formula - Single Bottle (45 Servings)

$75.50

$1.51 Cashback

This product qualifies for free or reduced cost shipping.

Learn More

Product info

Primary Benefits of nutraMetrix OPC-3® Skin Health Formula*


•    Supports a healthy complexion
•    Supports a smooth, soft and even-toned complexion
•    Promotes healthy functioning of the skin at the cellular level, which results in healthy, vibrant-looking skin
•    Replenishes essential vitamins and minerals that are co-factors for many enzyme reactions in vivo to help the entire skin to grow and cells to divide
•    Helps maintain normal cell growth
•    Supports healthy skin with key micronutrients to replenish and rejuvenate skin to look, feel and function its absolute best
•    Supports healthy joints
•    Supports healthy skin elasticity to keep skin looking young and firm (tight)
•    Helps maintain healthy collagen production
•    Helps maintain skin elasticity and moisture
•    Helps maintain healthy connective tissue
•    Maintains healthy collagen and elastin levels to help preserve the elasticity of skin
•    Plays a role in maintaining elasticity of capillaries in the dermis, which helps maintain healthy blood flow, minimizing the appearance of spider veins in the skin
•    Hyaluronic acid helps maintain healthy joint flexibility, especially in knees, by moisturizing joints
•    Helps maintain skin moisture
•    Helps maintain an optimal moisture balance in skin that can minimize the appearance of fine lines, wrinkles and pits
•    Promotes healing of minor skin injuries
•    Promotes healing of cuts and abrasions
•    Helps support the skin’s natural defenses from harmful environmental pollutants and chemicals
•    Demonstrates anti-inflammatory activity to assist in normalizing reddened, swollen or thick skin
•    Helps maintain microcirculation of skin capillaries for healthy oxygen and nutrient supply – part of our vascular system which “feeds” the skin to help keep it fresh and rejuvenated.
•    Powerful free-radical scavenger
•    Supports the immune system – a healthy body means healthy-looking skin
•    Promotes a healthy circulatory system including healthy capillaries, which ensures your whole body gets the nutrients it needs to stay healthy
•    Supports healthy circulation
•    Powerful antioxidant that provides the skin with a defense against damage and signs of aging
•    Provides antioxidant protection for the entire body – minimizes the damage that free radicals can wreak on your body
•    Helps promote overall health
•    Helps skin stay younger-looking
•    Helps maintain healthy hair and nails – biotin
•    Helps support healthy bones, teeth, joints and skin
•    Helps maintain normal muscle and nerve function, supports a healthy immune system, supports a healthy cardiovascular system and keeps bones strong
•    Adequate calcium and vitamin D throughout life, as part of a well-balanced diet, may reduce the risk of osteoporosis
•    Adequate calcium and vitamin D as part of a healthful diet, along with physical activity, may reduce the risk of osteoporosis in later life

Product Classification*


Product Classification*
Gluten Free – the finished product contains no detectable gluten

No Detectable GMOs – the finished product contains no detectable genetically modified organism

Isotonic-capable Drinkable Supplements – easy-to-swallow supplements in liquid form are immediately available to the body for absorption

Why Chose nutraMetrix OPC-3® Skin Health Formula*


nutraMetrix Isotonix OPC-3® Skin Health Formula is formulated to promote skin elasticity, support healthy collagen production, replenish essential vitamins and minerals for the skin, and provide the skin and body with improved antioxidant defenses. This product helps maintain skin health at the cellular level, nourishing and rejuvenating skin cells with some of the finest antioxidants available today, including grape seed extract, red wine extract, bilberry extract, citrus bioflavanoids and Pycnogenol®. They are powerful free radical scavengers that not only work to keep the skin healthy and beautiful, but also provide free radical scavenging abilities which are beneficial in a world filled with smog, pollution and other various unseen toxins. These antioxidants are coupled with specific vitamins and minerals that are conducive to cell growth and division. Cell proliferation is important in maintaining healthy, vibrant skin.*

nutraMetrix Isotonix OPC-3 Skin Health Formula is an isotonic-capable food supplement that is made from a combination of bilberry, grape seed, red wine, pine bark extracts and citrus extract bioflavonoids, all found to be powerful antioxidants. Oligomeric proanthocyanidins (OPCs) are bioflavonoids (complex organic plant compounds) found in fruits, vegetables and certain tree barks that provide exceptional nutritional benefits to the human body. Studies have shown OPCs to be up to 20 times more powerful than vitamin C and 50 times more powerful than vitamin E in neutralizing free radicals. Isotonix OPC-3 contains the only isotonic form of Pycnogenol in the world. Pycnogenol is a natural plant extract from the bark of the French maritime pine tree, and the most clinically researched and powerful bioflavonoid.

Isotonix Delivery System


Isotonix Delivery System
Isotonix - the World's Most Advanced Nutraceuticals

Isotonic, which means “same pressure,” bears the same chemical resemblance of the body’s blood, plasma and tears. All fluids in the body have a certain concentration, referred to as osmotic pressure. The body’s common osmotic pressure, which is isotonic, allows a consistent maintenance of body tissues. In order for a substance to be absorbed and used in the body’s metabolism, it must be transported in an isotonic state.

Isotonix dietary supplements are delivered in an isotonic solution. This means that the body has less work to do in obtaining maximum absorption. The isotonic state of the suspension allows nutrients to pass directly into the small intestine and be rapidly absorbed into the bloodstream.With Isotonix products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results.

Key Ingredients Found In nutraMetrix OPC-3® Skin Health Formula*


Grape Seed Extract (25 mg)
Grape seed extract is typically extracted from the seeds of red grapes (instead of white), which have a high content of compounds known as oligomeric proanthocyanidins (OPCs). Grape seed extract is extremely rich in polyphenols, compounds with high antioxidant activity. Grape seed extract has been found to maintain healthy cholesterol levels.

Red Wine Extract (25 mg)

Red wine extract is a powerful antioxidant. This extract is found in grape vines, roots, seeds and stalks, with the highest concentration in the skins. The antioxidant properties of red wine extract contribute to maintaining healthy circulation by strengthening capillaries, arteries and veins, and promoting overall cardiovascular health.

In the late 1990s, scientists took note of a phenomenon among the French. There were very low rates of cardiovascular problems in the provinces where residents consistently ate high fat foods and drank red wine. Scientists concluded that the protective properties of red wine have helped the French maintain cardiovascular health for years and subsequent scientific studies have further shown that the OPCs found in red wine are particularly beneficial for protecting the heart and blood vessels.

Pine Bark Extract (Pycnogenol®) (25 mg)
Pycnogenol is a natural plant extract from the bark of the maritime pine tree, which grows exclusively along the coast of southwest France in Les Landes de Gascogne. This unspoiled and natural forest environment is the unique source of pine bark. Pycnogenol is one of the most researched ingredients in the natural product marketplace. Published findings have demonstrated Pycnogenol’s wide array of beneficial effects on the body. Pine bark extract is an all natural combination of procyanidins, bioflavonoids and organic acids.

The extract has three basic properties — it is a powerful antioxidant, selectively binds to collagen and elastin, and promotes the normal production of endothelial nitric oxide, which promotes the normal dilation of blood vessels.

As one of the most potent natural scavenger of free radicals, Pycnogenol combats many aggressive free radicals before they cause oxidative stress to vital organs. Its super-antioxidant capabilities help support healthy blood platelet activity, support healthy blood glucose levels, reduce mild menstrual cramping and abdominal pain, maintain joint flexibility, promote cardiovascular health, promote healthy sperm quality, maintain healthy cholesterol levels and support a healthy complexion.

Bilberry Extract (25 mg)
Bilberry extract is derived from the leaves and berry-like fruit of a common European shrub closely related to the blueberry. Extracts of the ripe berry are known to contain flavonoid pigments known as anthocyanins, which are powerful antioxidants. Scientific studies confirm that bilberry extract supports healthy vision and venous circulation. Bilberry extract helps maintain healthy circulation by strengthening capillaries, arteries and veins.

Citrus Extract (Bioflavonoids) (25 mg)
Bioflavonoids are antioxidants found in certain plants that act as light filters, which protect delicate DNA chains and other important macromolecules by absorbing ultraviolet radiation. They have been found to promote cardiovascular health, help maintain healthy circulation by strengthening capillaries, arteries and veins, and demonstrate anti-inflammatory activity.

Frequently Asked Questions*


What is nutraMetrix Isotonix OPC-3® Skin Health Formula? What exactly does it do?
nutraMetrix Isotonix OPC-3 Skin Health Formula is a revolutionary product that helps to improve and maintain the appearance of healthy, beautiful skin from the inside out. It uses the most powerful free radical scavenging antioxidants known to date. The purest and best-researched OPCs chosen for nutraMetrix Isotonix OPC-3 Skin Health Formula are derived from grapes, bilberries, Pycnogenol (pine bark) and citrus-fruit. These have the highest total polyphenol content. In addition to being powerful antioxidants, these OPCs also promote skin health. These powerful bioflavanoids are considered many times more powerful than vitamins C and E as free radical scavengers. They do, however, work well with both vitamin C and E.
Antioxidants found in nutraMetrix Isotonix OPC-3 Skin Health Formula scavenge free radicals within cells and promote optimal cellular functioning. The OPCs support your skin's natural ability to regenerate new epidermal cells, paving the way for true splendor in the way of skin beautification. nutraMetrix Isotonix OPC-3 Skin Health Formula helps to replenish the skin's vitamins and minerals which promotes the growth and division of skin cells. It promotes a strong vascular network in the skin, thus supporting the elasticity of the skin. It also supports collagen production, promotes joint health and supports nerve, muscle and skin cell function.
This combination of powerful OPCs is unique to nutraMetrix Isotonix OPC-3 Skin Health Formula as is the Isotonix delivery system, which enables rapid and highly efficient absorption of OPC's, vitamins and minerals. 

Who should take nutraMetrix® Isotonix OPC-3® Skin Health FormulaWho wouldn't want to be noticed for healthy-looking skin, especially when it's cultivated at the cellular level where it really counts? All of us are constantly in contact with an environment that can be quite stressful upon the delicate nature of our skin. Everyone should take precautions against the effects of stress, aging and the environment when it comes to maintaining skin health. This product should be taken by anyone over the age of 18 who wants to look, feel and perform at their best, enabling them to reveal their beauty from the inside out.

Can men take nutraMetrix Isotonix OPC-3 Skin Health Formula?  Yes, this product is for anyone who wants to maintain healthy, youthful-looking skin.

What is Pycnogenol®? Pycnogenol® is the trademark of Horphag Research (UK) Ltd. for a standardized extract of bark of the French maritime pine tree. Pycnogenol® is renowned for its extensive clinical research with more than 120 studies published in peer-reviewed medical journals. The flavonoids in Pycnogenol® are powerful as antioxidants, and they promote cardiovascular health, support normal platelet activity and support healthy blood circulation and blood pressure.

When can I expect results?   Within minutes after consumption of nutraMetrix Isotonix OPC-3 Skin Health Formula, the proanthocyanidins are delivered to the blood stream where they immediately take action, supporting healthy blood flow. nutraMetrix Isotonix OPC-3 Skin Health Formula supports healthy blood perfusion all-over the body, which helps promote a healthy oxygen and nutrient supply as well as healthy waste removal. 

OPCs support collagen production in the skin, which increases smoothness and elasticity. It requires patience until skin cells have renewed significant amounts of collagen to show visible effects. Take nutraMetrix Isotonix OPC-3 Skin Health Formula to keep skin cells at their peak vitality.

On a short-term basis many people notice a fresher-looking skin complexion. 

What is nutraMetrix Isotonix OPC-3®? nutraMetrix Isotonix OPC-3 is a dietary supplement that bears some of the most powerful bioflavonoids currently known to research scientists. These bioflavonoids are scientifically termed oligomeric proanthocyanidins, commonly abbreviated OPCs. The purest and best-researched OPCs chosen for OPC-3 are prepared from grape seed, red wine, bilberries, Pycnogenol from pine bark and citrus fruit. This combination of powerful OPCs is unique to OPC-3, as is the Isotonix® delivery system, which enables rapid and highly efficient absorption of the OPCs. nutraMetrix Isotonix OPC-3 has been shown to provide a variety of health benefits including but not limited to combating free radicals, demonstrating anti-inflammatory activity, helping maintain healthy cholesterol levels, helping maintain healthy circulation by strengthening capillaries, arteries and veins, helping maintain joint flexibility, helping promote/support cardiovascular health, helping reduce mild menstrual cramping, helping support visual health/visual acuity, scavenging free radicals, promoting/supporting healthy blood vessel dilation, promoting/supporting healthy nitric oxide levels, supporting a healthy complexion, supporting healthy blood glucose levels, supporting healthy platelet activity and supporting healthy sperm quality.*
  
What is a bioflavonoid? Bioflavonoids are complex organic plant compounds. Plants and fruits differ in colors based on the specific bioflavonoids they contain. An increasing number of clinical studies have shown how bioflavonoids support health. Bioflavonoids found in OPCs play a key role in cardiovascular health and maintaining vascular integrity. Bioflavonoids have been shown to demonstrate support for healthy circulation and cell vitality. Normal collagen renewal is promoted, which supports firmness of the skin, joint cartilage and connective tissue. 

What sets nutraMetrix Isotonix OPC-3® Skin Health Formula apart from other bioflavonoid products?  nutraMetrix Isotonix OPC-3 offers scientifically supported OPCs, found to be the most powerful antioxidants for human health. In addition to being powerful antioxidants, these individual OPCs have been shown to provide a myriad of specific health benefits. This science-driven selection of OPCs is unique to OPC-3, as is the Isotonix delivery system, which enables rapid and highly efficient absorption of the OPCs. The powerful nutrients, in combination with the highly effective delivery system, makes OPC-3 the most powerful free radical scavenging product available.*

Is nutraMetrix Isotonix OPC-3® Skin Health Formula safe? Yes. OPCs are among the most valuable constituents of a healthy human diet. OPCs have been researched and used for over 30 years throughout Europe. Extensive safety studies were conducted which revealed no evidence for human toxicity or allergic reactions. OPC-3 contains pure OPCs in combination with carefully balanced quantities of potassium and fructose/glucose, which set up the isotonic delivery system. OPC-3 is free of harmful chemicals, preservatives and alcohol. OPC-3 should be taken as directed. 

How long does it take to benefit from nutraMetrix Isotonix OPC-3® Skin Health Formula? OPC-3 not only provides the most powerful OPCs available, the unique Isotonix delivery system ensures that the small intestine rapidly absorbs the OPCs, which are available in the blood stream within minutes. This is because the OPCs are delivered in liquid form. The liquid is isotonic, which means it duplicates the environment in our cells and blood stream regarding pH, electrolytes, etc. This enables the OPCs to enter the body easily and with a high level of bioavailability. Because of the rapid absorbability, the body should benefit from nutraMetrix Isotonix OPC-3 almost immediately.

What is the advantage of taking nutraMetrix Isotonix OPC-3® regularly?  Many effects of OPC-3 start to work after a single serving. Studies with human volunteers have found that the health benefits of OPCs may take a while to occur. This may be the case for health concerns resulting from everyday wear and tear, where time simply has taken its toll. Taking nutraMetrix Isotonix OPC-3 daily enables the body to sustain a consistent antioxidant defense.

Why should everyone take nutraMetrix Isotonix OPC-3®? Free radical damage and oxidative stress everyone is subject to. Free radicals develop as byproducts of physiological processes that occur within the body. This damage does not cause noticeable harm at first, yet may add up over the years. This process is largely responsible for the aging process. Free radicals have been linked directly to premature aging, poor circulation, poor heart health and poor immune health. 

OPCs are the most powerful natural free radical neutralizers and you get the best of all OPCs by taking Isotonix OPC-3. Regular use every day is vital for keeping free radicals in check and a long, healthy life. Laboratory studies have shown that OPCs are more powerful antioxidants than vitamin C and vitamin E. 

Can you take nutraMetrix Isotonix OPC-3® in soda, juice, coffee, etc., rather than water?
It is possible but not recommended. This product should only be taken as directed. In order to keep the product in an isotonic form and to achieve the maximum delivery speed, it needs to be taken on an empty stomach with 2 oz. of water per capful. Mixing the products with anything else besides other Isotonix products and water slows down the delivery time and may affect the percentage of uptake.

I am healthy and athletic, why should I take nutraMetrix Isotonix OPC-3? Everyone is vulnerable to the aging process caused by continuous free radical damage. Athletes tend to be exposed to elevated levels of oxidative stress. Free radicals develop as byproducts during metabolism when calories are processed with oxygen. Athletes inhale 10 to 20 times more oxygen during physical activity over rest periods. The increase in activity creates additional free radicals. In fact, these free radicals are known to limit performance, as free radicals appear to take their toll on muscle tissue. Studies on recreational athletes have shown a 20 percent endurance increase with OPCs, as compared to a control group receiving a placebo. Another study has shown that athletes using OPCs suffered significantly less muscle cramping during and after performing. nutraMetrix Isotonix OPC-3 helps to maintain healthy blood flow and this supports oxygen supply to muscles.* 

Does OPC-3 have visible benefits? As OPCs support collagen production in the skin, an increase of smoothness and support of elasticity is the natural result. Such an effect was objectively measured in women aged 40 years and older. Skin smoothness was increased after three months as measured by 3-dimensional topography. It requires patience to show visible effects. It is essential to continuously take OPC-3 to keep skin cells at their peak vitality.*

On a short-term basis, many people notice a fresher-looking skin complexion. This is a result of healthy blood microcirculation, which helps detoxify the skin and improves the nutrient supply. Regular use of OPC-3 helps defy photo-aging of the skin.

Does OPC-3 have a rejuvenating effect? The damage caused by free radicals adds up with time. A cause for more worry is the fact that your body's own mechanisms to keep free radicals in check decline with increasing age - when you need them the most. Suddenly, we find ourselves confronted with some typical age-related problems. Some cells of our body are more vulnerable to free radicals than others. OPC-3 has the ability to go in and do a knockout job, cleaning and scavenging the free radicals that feast on cellular energy, and take it away from vital processes.

What are the cardiovascular health benefits of OPCs? Scientist Albert Szent-Gyorgyi, who received the Nobel Prize for the discovery of vitamin C, discovered OPCs. Szent-Györgyi found that OPCs work in a similar fashion. They strengthen the walls of arteries, veins and capillaries.

In the past 20 years scientists discovered that OPCs bear a lot more benefits for the cardiovascular system. Epidemiological studies have shown that regular intake of powerful OPC antioxidants supports a healthy cardiovascular system. OPCs appear to be particularly helpful in maintaining healthy cholesterol levels and healthy arteries.

Pycnogenol® in nutraMetrix Isotonix OPC-3 plays a key role, as it promotes healthy nitric oxide (NO) levels. NO is a tiny molecule which serves as a key messenger molecule in the blood stream. It promotes relaxation of smooth muscle-surrounding arteries and supports normal artery diameter and blood flow. Healthy NO levels help maintain normal blood pressure. This benefit has been explicitly demonstrated with Pycnogenol in two clinical studies. NO also promotes healthy blood platelet activity thus preserving a normal, fluid environment. OPCs are especially helpful for smokers. OPC-3 packs a powerful punch when it comes to maintaining excellent cardiovascular health.

How can OPC-3® help my eyes? Loss of eyesight is the disability people fear more than all others. nutraMetrix Isotonix OPC-3 contains specific OPCs successfully tested for eye health.

Bilberry extract was shown to help maintain overall eye health in the vast majority of people in a study.

Pycnogenol has been shown to support healthy capillaries in the eye. nutraMetrix Isotonix OPC-3 helps maintain visual health and supports visual acuity.

Does OPC-3 have benefits specifically for women? Some OPCs were shown in clinical trials to help women who suffer from mild pain and cramping during the menstrual period. When women were supplemented with OPCs, starting at least a week before their menstrual period, pain values were found to be significantly lowered. 

Scientific Studies For nutraMetrix OPC-3® Skin Health Formula*


  • Schönlau, F., et al. The cosmeceutical Pycnogenol ® . J Appl Cosmetology 20: 241-6, 2002.
  • Shi, J., et al. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6:291-9, 2003. Review.
  • Chernoff R., et al. Protein and older adults. J Am Coll Nutr. 23(6 Suppl):627S-630S, 2004. Review.
  • Naidu, K., et al. Vitamin C in human health and disease is still a mystery? An overview. Nutr J. 2:7, 2003.
  • Diker-Cohen, T., et al. Vitamin D protects keratinocytes from apoptosis induced by osmotic shock, oxidative stress, and tumor necrosis factor. Ann N Y Acad Sci. 1010:350-3, 2003.
  • Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol ® ), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40:158-68, 2002. Review.
  • Meyer, L., et al. Age-dependent changes of hyaluronan in human skin. J Invest Dermatol. 102:385-9, 1994.
  • Weindl, G., et al. Hyaluronic acid in the treatment and prevention of skin diseases: molecular biological, pharmaceutical and clinical aspects. Skin Pharmacol Physiol. 17(5):207-213, 2004.
  • Nachbar, F., et al. The role of vitamin E in normal and damaged skin. J Mol Med. 73(1):7-17, 1995.
  • Segger, D. and Schönlau, F. Supplementation with Evelle ® improves skin smoothness and elasticity in a double-blind, placebo-controlled study with 62 women. Journal of Dermatological Treatment 15:222-26, 2004.
  • MacKay, N., et al. Nutritional support for wound healing. Alternative Medicine Review. 8: 359-77, 2003.
  • Hata, R., et al. Regulation of collagen metabolism and cell growth by epidermal growth factor and ascorbate in cultured human skin fibroblasts. Eur J Biochem. 173:216-267, 1988.
  • Ghersetich, I., et al. Hyaluronic acid in cutaneous intrinsic aging. International Journal of Dermatology. 33(2):119-122, 1994.
  • Geesin, J., et al. Regulation of collagen synthesis in human dermal fibroblasts by the sodium and magnesium salts of ascorbyl-2-phosphate. Skin Pharmacol. 6:65-71, 1993.
  • Block, A., and Bettelheim, F. Water Vapor Sorption of Hyaluronic Acid. Biochim Biophys Acta 201:69, 1970.
  • Ghersetich, I., et al. Hyaluronic acid in cutaneous intrinsic aging. Int J Dermatology. 33(2):119-122, 1994.
  • Chen, W., et al. Functions of hyaluronan in wound repair. Wound Repair Regen. 7:79-89, 1999.
  • Casado,F.J., et al. LMW hyaluronic acid to induce epidermal regeneration.(low molecular weight). Drug & Cosmetic Industry. 148:30-34, 1991.
  • Gross, R., et al. The effect of ascorbate on wound healing. Int Ophthalmol Clin. 40:51-7, 2000. Review.
  • Gamady, A., et al. Vitamin D enhances mitogenesis mediated by keratinocyte growth factor receptor in keratinocytes. J Cell Biochem. 89(3):440-449, 2003.
  • Price, R., et al. The role of hyaluronic acid in wound healing: assessment of clinical evidence. Am J Clin Dermatol. 6:393-402, 2005.
  • Chernoff R., et al. Protein and older adults. J Am Coll Nutr. 23(6 Suppl):627S-630S, 2004. Review.
  • Saliou, C., et al. Solar ultraviolet induced erythema in human skin and nuclear factor kappa B dependent gene expression in keratinocytes are modulated by a French maritime pine bark extract. Free Radic Biol Med. 15:30 (2): 154-60, 2001.
  • Fine, AM. Oligomeric proanthocyanidin complexes: history, structure, and phytopharmaceutical applications. Altern Med Rev 5:144-51, 2000. Review.
  • Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol ® ), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40:158-68, 2002. Review.
  • Frémont, L. Biological effects of resveratrol. Life Sciences 66: 663-673, 2000.
  • Gulati, O. Pycnogenol ® in venous disorders: a review. European Bulletin of Drug Research 7: 1-13, 1999.
  • Takada, Y., et al. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene 23: 9247-58, 2004.
  • Blazsó, G., et al. Anti-inflammatory and superoxide radical scavenging activities of a procyanidins containing extract from the bark of Pinus pinaster Sol. and its fractions. Pharm Pharmacol Lett 3: 217-20, 1994.
  • Bayeta, E., et al. Pycnogenol inhibits generation of inflammatory mediators in macrophages. Nutrition Research 20: 249-259, 2000.
  • Cho, K., et al. Effect of bioflavonoids extracted from the bark of Pinus maritima on proinflammatory cytokine interlukin-1 production in lipopolysaccharide-stimulated RAW 264. 7. Toxicology and Applied Pharmacology 168: 64-71, 2000.
  • Cho, K., et al. Inhibition mechanisms of bioflavonoids extracted from the bark of Pinus maritima on the expression of proinflammatory cytokines. Annals of the NY Academy of Sciences 928: 141-156, 2001.
  • Hosseini, S., et al. Pycnogenol ® in the management of asthma. Journal of Medicinal Food 4: 201-209, 2001. HHHh
  • Rohdewald, P. Pycnogenol ® . In “Flavonoids in Health and Disease”. Ed. Catherine Rice-Evans and Lester Packer. New York: Marcel Dekker, Inc., 1998. 405-19.
  • Diker-Cohen, T., et al. Vitamin D protects keratinocytes from apoptosis induced by osmotic shock, oxidative stress, and tumor necrosis factor. Ann N Y Acad Sci. 1010:350-3, 2003.
  • Packer, L., et al. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 27:704-24, 1999. Review.
  • Monograph. Vaccinium myrtillus (bilberry). Altern Med Rev 6:500-4, 2001.
  • Watson, R. Pycnogenol ® and cardiovascular health. Evidence-Based Integrative Medicine 1: 27-32, 2003.
  • Gulati, O. Pycnogenol ® in venous disorders: a review. European Bulletin of Drug Research 7: 1-13, 1999.
  • Devaraj, S., et al. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37:931-4, 2002.
  • Freedman, J., et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 103:2792-8, 2001.
  • Shi, J., et al. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6:291-9, 2003. Review.
  • Saito, M., et al. Antiulcer activity of grape seed extract and procyanidins. J Agric Food Chem 46: 1460-4, 1998.
  • Nuttall SL, Kendall MJ, Bombardelli E, Morazzoni P. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm Ther 23: 385-89, 1998.
  • Wei, Z., et al. Pycnogenol enhances endothelial cell antioxidant defense. Redox Report 3: 219-24, 1997.

Reviews


Customer Reviews
  • (45)
  • (24)
  • (5)
  • (1)
  • (1)

Displaying reviews  1 - 5 of 76

on

Isotonix OPC-3® Beauty Blend

Using this product along with the Isotonix Essentials Kit is much better than taking a multi-vitamin pill and it works much faster. I would also highly recommend this product too.

on

Dissolves instantly in water

Like all vitamins, the taste is unique - but it instantly dissolves in water and the benefits outweigh something like liquid fizzy gummy bears.

on

We Are ALL Amazed!!

Not only am I experiencing amazing results with this product, but my clients report that they see a visible difference in their hair, skin, and nails!! The complements that we receive from onlookers is numerous!! I love Isotonix products, but OPC-3 Beauty Blend has to be my absolute favorite supplement!!

on

  • Shop Consultant

Won't go without this product!

I never miss a morning of taking my beauty blend. It has forever changed the appearance of my skin and my overall health!

on

Outstanding product

Love Isotonix products

One or more of the reviews shown may have been posted by a nutraMetrix or SHOP Consultant (An independent distributor of nutraMetrix and Market America products) or a nutraMetrix HP (A health professional who is an independent distributor of nutraMetrix and Market America products).