Much like an atom is the foundation of the universe, a cell is the foundation of the human body. In the quest for long life and optimal health, scientists have delved into the intricate world of cellular function, DNA integrity and energy production. One significant compound stands out amongst the rest as being a crucial part of human metabolism and its aging process: nicotinamide adenine dinucleotide (NAD). Whether we are talking about simple bacteria or the complexity of human metabolism, NAD and its metabolic counterpart NADH are what the cell relies on for life.

These compounds hold the key to supporting healthy metabolism and aging. NAD is a coenzyme that is essential for carrying out cellular and metabolic functions, such as maintaining healthy levels of ATP production within the cells, supporting the body’s cellular regeneration process and supporting healthy mitochondrial metabolism. nutraMetrix Prime Anti-Aging Nutraceuticals^® NAD⁺ delivers 250 mg of nicotinamide riboside (NR), paired with 50 mg of pterostilbene, both of which have been scientifically shown to support NAD levels within our cells. NAD is connected to one’s health, youth and quality of life; you simply cannot live without it since it is essential for cellular life. The youth of our cells is associated with our physical and cognitive health and overall well-being. nutraMetrix Prime NAD⁺ is a powerful gluten-free, non-GMO, cutting-edge formula that works to support healthy NAD production and helps maintain NAD levels in aging adults and adults with demanding fitness, work and travel schedules. If it feels like time is always running against you, it's time to consider your energy reserve and NAD. Whether you are looking to combat the natural age-related decline of NAD levels or support NAD levels for those living NAD-depleting lifestyles, the ultimate goal of nutraMetrix Prime NAD⁺ is helping you sustain a healthy reservoir of the youthful NAD molecule.

NAD is naturally occurring; it resides in every living cell in the body and has been shown to be strongly linked to keeping one's youth. Various sources of vitamin B3 are known as precursors of NAD, meaning they influence or help build upon the production of NAD. The balance between the consumption and synthesis of NAD plays into the replenishment or concentration levels of NAD within our cells. There are three pathways that are responsible for helping to maintain this balance, with each one working differently to convert NAD precursors into NAD for our cells. nutraMetrix Prime NAD⁺ is specifically formulated with NR; this precursor is linked to the salvage pathway which plays a unique role in replenishing or restoring the pools of NAD in our cells. NAD, the oxidized form of nicotinamide adenine dinucleotides, and NADH, the reduced form, make up the NAD⁺/NADH redox ratio, which provides insight as to how well our cells are creating energy or ATP and portrays the current condition of cellular health and metabolism. NAD-depleting lifestyles can negatively impact this ratio, throwing it off balance, and imbalances of this ratio are associated with cellular aging. Consuming more NAD precursors that promote the increase of NAD is the longevity secret for helping to maintain a healthy balance of this ratio.

Younger people naturally have higher levels of NAD pools in their cells. Additionally, observational research shows that older individuals who do not display the same biomarkers of aging as their age group are also correlated with higher pools of NAD. This demonstrates why sufficient levels are correlated with cell youth and longevity. Studies have shown that the body’s natural NAD production begins to first decrease in skin and within the brain as we age, making these precursors of higher importance to help sustain NAD levels. Other cellular pools also are impacted by age and the loss of NAD; such as mitochondria, adipose tissue and muscle- emphasizing that NAD is a crucial part of healthy aging. nutraMetrix Prime NAD⁺ is formulated with two powerful ingredients, NR and pterostilbene, both of which have scientifically proven their ability to support cellular health. A study analyzing the effects of taking both the precursor NR and pterostilbene for an eight-week period (in which participants were either administered a placebo, a single serving or a double serving of the recommended amount) demonstrated its ability promote an increase of NAD levels. When analyzing concentration of NAD levels in the participants’ blood after four weeks, the study found that the group who took the recommended serving showed a 40% increase and the group who was administered a double serving showed a 90% increase of NAD levels in the blood; the placebo group showed no change. In addition, the levels reported at four weeks remained consistent for both groups who were administered NR and pterostilbene supplementation when measured at 60 days.

While supplementation of NAD precursors is what promotes an extra reserve of NAD, it is NAD itself that really does the heavy lifting and influences all the different working parts of the cell that safeguard you from the inevitable cellular aging process. One influencing factor is the promotion of sirtuins (SIRTs) activity, also known as the “longevity genes.” These genes are enzymes that assist in cellular metabolism and help protect the cells’ state of equilibrium or balance when the cells encounter stress. nutraMetrix Prime NAD⁺ promotes the normal activity of the SIRT-1 gene, a treasured gene that protects the body from the negative effects of free radicals. SIRT-1 is associated with the anti-aging pathways, longevity and the modulation of a whirlwind of processes including DNA repair, genome maintenance, mitochondrial functioning and cellular metabolism. When our DNA becomes damaged, it can deplete the cell’s NAD levels, leading to a decrease in sirtuin activity. Therefore, stockpiling a healthy savings account of NAD naturally makes it easier for our cells to detoxify and aids in preserving the integrity of our genetic blueprint for optimal health.

While maintaining healthy NAD production promotes healthy sirtuin activity, healthy sirtuin activity helps support the of telomeres. Telomeres are genome-protective caps located at the end of chromosomes: they act like the clear coating at the end of a shoelace string that keeps the shoelace from fraying. These little caps can indicate the age or suggested lifespan of a cell, in which the longer in length the telomere is, the better. Each time your cells divide, the chromosomal telomeres become shortened, and over time they inevitably reach the point where the cell can no longer replicate. Evidence shows that shorter telomeres contain lower NAD levels. Just as NAD levels decrease with age, telomeres naturally shorten with age and both are correlated with the health of the cells and their ability to support the body’s cellular regeneration process. Studies suggest that taking both NR and pterostilbene together can support each other's bioavailability, or their ability to be absorbed by the cells. The bioavailability of pterostilbene is an essential factor that promotes the normal activity of the SIRT-1 gene. Pterostilbene also acts as the golden sword for the aging mind, as the autophagy-influencing antioxidant supports the mediation of SIRT-1 and SIRT-2, which may help maintain neurological and cognitive health. In addition, pterostilbene has been shown to be 60% more bioavailable and has a 91 minute longer half-life than its well-known stilbene counterpart, resveratrol; this means that pterostilbene is actively working in your system to assist the cells for a longer period.

Regardless of age, practicing poor lifestyle habits such as smoking, drinking alcohol, lack of sleep or exercise, unhealthy diets and other factors can have depleting effects on maintaining an optimal reservoir of NAD, making NAD-promoting supplementation beneficial for even those who are considered to be younger than the age when metabolic energy may naturally begin to slow down. NR and pterostilbene offer a treasure trove of benefits for our overall well-being and bring you one step further to helping you hack the aging process. With nutraMetrix Prime NAD⁺ on your side, “The golden age is before us, not behind us.” You don’t have to wait until you are aged to start caring about aging.

*These statements have not been evaluated by the Food and Drug Administration. This product(s) is not intended to diagnose, treat, cure, or prevent any disease.

1. What are the directions of use for this product?
   Adults, take 2 capsules every morning with or without food. This supplement is meant to be taken only once a day.
   
   
2. Are there any warnings for this product?
   If you are currently using any prescription drugs or have an ongoing medical condition, consult your healthcare provider before using this product. Do not take this product if you are pregnant or breastfeeding.
   
   
3. What are the two factors that play into the continuous replenishment of NAD in the cells?
   The consumption and synthesis of NAD are two factors that play into the replenishment or concentration levels of NAD within the cells. There are three pathways that are responsible for helping to maintain this balance, known as the Preiss-Handler pathway, de novo biosynthesis pathway and the salvage pathway. Each of these pathways works in different ways to help the precursor NR and other NAD precursors convert into NAD for the body’s cells. The NAD precursor NR is specifically linked to the salvage pathway.
   
   
4. What is NAD⁺/NADH redox ratio?
   NAD is recognized as the oxidized form of nicotinamide adenine dinucleotides whereas NADH is the reduced form. Overall, the NAD⁺/NADH redox ratio explains how well the cells are creating energy or ATP, portraying the current condition of cellular health and metabolism. NAD-depleting lifestyles can negatively impact this ratio, throwing it off balance and leading to a decreased ratio which is also associated with age. Consuming more NAD precursors which help support levels of NAD is effective for helping to maintain a healthy balance of this ratio.
   
   
5. What can deplete NAD levels in the body other than aging?
   Regardless of age, young or rough lifestyle habits can contribute to the increased need of NAD. Smoking, alcohol consumption, not exercising, being overweight, getting an inadequate amount of sleep and eating an unhealthy diet are all factors that can lead to NAD depletion.
   
   
6. Is this product vegetarian or vegan?
   This product contains no animal-derived ingredients and is suitable for vegetarians and vegans.
   
   
7. How does nutraMetrix Prime NAD⁺ differ from nutraMetrix Heart Health™ Advanced Co-Q10 on a cellular level and nutraMetrix Awake® Energy Shot on an energy level?
   With age, the body produces less Co-Q10 naturally; Heart Health Advanced Co-Q10 provides additional Co-Q10 to the body which helps generate energy in every cell of the human body and promotes cardiovascular health. Awake Energy Shot is formulated with B vitamins and caffeine to provide a quick boost or bump of energy when needed. Prime NAD⁺ is not a short-lived type of energy supplement but an energy supplement for cellular longevity and vitality.
   
   
8. What are NAD precursors?
   Various sources of vitamin B3, including nicotinamide riboside (NR), nicotinic acid (NA), nicotinamide (NAM), nicotinamide mononucleotide (NMN), and tryptophan (Trp), are known as precursors of NAD, meaning they influence or help build upon the production of NAD.
   
   
9. What is the half-life of pterostilbene in comparison to resveratrol?
   Pterostilbene has a much longer half-life (105 minutes) than resveratrol (14 minutes), meaning that pterostilbene is actively working in your system for a longer time.
   
   
10. How do nutraMetrix Prime NAD⁺ and nutraMetrix Heart Health Advanced Co-Q10 work differently to support cell functioning?
    NAD is the spark that initiates what is called electron-transport chain, which is required to manufacture adenosine triphosphate (ATP) or the energy currency of our cells; it is cellular energy at its core and the spark of human metabolism. Heart Health Advanced Co-Q10 contains coenzyme Q10, which acts as a necessary fuel product to support mitochondrial generation. Co-Q10 safeguards the mitochondria from oxidative stress and helps create a healthy environment for mitochondrial activity. In short, NAD is the literal spark for energy, where Co-Q10 is the fuel.
    
    
11. What are other ways you can promote sirtuin activity?
    Sirtuins are special molecules that are associated with supporting the cells’ lifespan. In addition to NR and pterostilbene, the youthful, antioxidant-rich molecule, sirtuin activity can also be promoted by supplementing with resveratrol and curcumin. Exercise and a decrease in caloric intake have also been shown to be effective ways to naturally increase the activity of sirtuins.
    
    
12. What are telomeres?
    Telomeres are genome-protective caps that are located at the ends of chromosomes and indicate the age or suggested lifespan of a cell, in which the longer the telomere in length, the better. Telomeres are like the clear coating at the end of the shoelace string that keeps the lace from fraying; each time your cells divide, the chromosomal telomeres become shorter. Where maintaining healthy NAD production promotes healthy sirtuin activity, healthy sirtuin activity helps support the regulation of telomeres. Evidence shows that shorter telomeres contain lower NAD Just as NAD levels decrease with age, telomeres naturally shorten with age and both are correlated with the health of the cells and their ability to support the body’s cellular regeneration process.
    
    
13. What is the goal of nutraMetrix Prime NAD⁺?
    While all our Prime products are crafted to promote healthy aging at every level (including vision health, vascular strength, joint or hormone support), nutraMetrix Prime NAD⁺ was specifically formulated to help you maintain a healthy reservoir of the youthful NAD molecule to help combat the cellular aging process.
    
    
14. What foods contain NAD precursors or naturally assist in promoting NAD?
    Foods such as broccoli, cabbage, cucumber, avocado and tomato contain the NAD precursor NMN. Other foods containing higher levels of niacin and tryptophan, such as dairy, fish, beef, turkey and green vegetables, also help naturally increase NAD.
    
    
15. How was NAD discovered?
    NAD was discovered over 100 years ago while scientists were doing experiments on fermentation in which yeast cells metabolize sugar and convert it into alcohol. Around twenty years later, scientists successfully separated the components of the yeast cells and discovered the chemical shape of the NAD molecule. In 1958, Jack Preiss and Phillip Handler showed how nicotonic acid is converted to NAD and identified responsible enzymes. The pathway that converts nicotonic acid to NAD is named the Preiss-Handler pathway.
    

*These statements have not been evaluated by the Food and Drug Administration. This product(s) is not intended to diagnose, treat, cure, or prevent any disease.

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