nutraMetrix Prime™ Joint Support Formula by Isotonix® - Single Bottle (45 Servings)

• Promotes optimal joint health
• Helps maintain joint comfort
• Helps maintain healthy joint fluidity and flexibility
• Promotes normal cartilage synthesis and regeneration
• Supports normal, healthy levels of COX-2 and 5-LOX
• Gluten-Free
• Non-GMO

As the body ages, many people experience joint discomfort. One option is to take a joint supplement to help promote overall bone and joint health. When looking at a joint supplement, there are three main ingredients found in most products on the market: glucosamine, chondroitin and methylsulfonylmethane, more commonly referred to as MSM.

The research on both chondroitin and MSM is very controversial. Chondroitin, for instance, has very poor absorption due to its high molecular weight. Also, one of chondroitin’s mechanisms is to increase the hyaluronic acid content of synovial fluid; while the new nutraMetrix Prime Joint Support Formula by Isotonix directly provides hyaluronic acid. Hyaluronic acid plays an important role in tissue hydration, lubrication and cellular function. Likewise, research on MSM is not conclusive. In fact, it takes large quantities of MSM daily (2-6 grams) to make a difference and see effects.

On the other hand, the research behind glucosamine is consistent and its benefits effective. nutraMetrix Prime Joint Support Formula contains glucosamine. An aminomonosaccharide (a combination of the amino acid — glutamine and a sugar — glucose), glucosamine is concentrated in joint cartilage and has been scientifically proven to support healthy joint function and promote the normal production of synovial fluid, which lubricates joints and regenerates cartilage.

The natural aging process affects everyone and proper exercise, sleep and supplementation are essential for healthy living. Prime Joint Support Formula also contains the powerful antioxidant Pycnogenol®, which science has shown help maintain the body’s natural defenses by inhibiting metabolic responses associated with the normal aging process.

Gluten-Free - The finished product contains no detectable gluten (<10ppm gluten)

No Detectable GMOs - The finished product contains no detectable genetically-modified organisms

Isotonic-Capable Drinkable Supplements - Easy-to-swallow supplements in liquid form are immediately available to the body for absorption

Quality Standards - GMP Operations and Standardized Ingredients

Checked For: Heavy Metals, Microbiological Contaminants, Allergens, Residual Solvents, Potency, Purity and Identity

Glucosamine (HCl): 1000 mg
Glucosamine is a molecule that is naturally synthesized in the body from glucose and the amino acid glutamine. Glucosamine is an important constituent of glycosaminoglycans in cartilage matrix and synovial fluid. As our bodies age, we are less able to produce glucosamine, resulting in cartilage that is less flexible and weak. Although the mechanism is currently unclear, studies have shown that glucosamine supplementation can support normal, healthy cartilage cell production to help maintain overall joint health.

Pine Bark Extract (Pycnogenol®): 25 mg
Pycnogenol is a water-soluble flavonoid complex with powerful benefits. Pycnogenol, similar to the proanthocyanins found in grape seeds, is extracted from the bark of the French Maritime Pine tree. It is an essential component of the body’s defense system, and can be triggered from numerous internal and external factors. Pycnogenol has been shown help maintain the body’s natural defenses by inhibiting metabolic responses associated with the normal aging process. Research has shown that Pycnogenol may inhibit the activation of NF-kappa B and AP-1. Pycnogenol supplementation can also promote normal COX-2 and 5-LOX gene expression, and support healthy leukotriene biosynthesis. In addition, studies have shown the ability of Pycnogenol to cross-link collagen fibers and strengthen connective tissue proteins. To learn more about the relationship between Pycnogenol and joint health, follow the link below to read the full text studies.

Hyaluronic Acid (Sodium Hyaluronate): 25 mg
Hyaluronic acid plays an important role in tissue hydration, lubrication and cellular function. Although it is produced naturally by the body, the level of hyaluronic acid diminishes with age, contributing to joint discomfort. It is a key component of cartilage, and is important for skin, joint and eye health. Hyaluronic acid has been shown to help maintain strong, healthy cartilage. It may also enhance synovial fluid production and promote normal healing.

Are there any people who should not take nutraMetrix Prime™ Joint Support Formula by Isotonix®?
If you are currently taking warfarin (Coumadin®), other anti-platelet/anti-coagulant medications, anti-hypertensive medications, or have an ongoing medical condition, you should consult your physician before using this product. If you have a known allergy to shellfish, do not take this product. Women who are pregnant or nursing should not take this product.

How should I take nutraMetri® Prime™ Joint Support Formula by Isotonix®?
On an empty stomach, take two cupfuls daily or as directed by your healthcare professional.

What other products should I take with nutraMetrix Prime™ Joint Support Formula by Isotonix® to support my joint health?
nutraMetrix Heart Health™ Essential Omega III is a great pair with nutraMetrix Prime Joint Support Formula, as omega III fatty acids have been shown to support healthy joint lubrication.

How often should I take nutraMetrix Prime™ Joint Support Formula by Isotonix®?
This product is most effective when taken daily.

How much Pycnogenol is in nutraMetrix Prime™ Joint Support Formula by Isotonix®?
There are 25 milligrams of Pycnogenol in each daily serving.

• James, C. and Uhl, T. A review of articular cartilage pathology and the use of glucosamine sulfate. Journal of Athletic Training. 36(4): 413-419, 2001.
• Julovi, S., et al. Inhibition of interleukin-1beta-stimulated production of matrix metalloproteinases by hyaluronan via CD44 in human articular cartilage. Arthritis and Rheumatism. 50(2): 516-525, 2004.
• Laurent, T., et al. Functions of hyaluronan. Annals of the Rheumatic Disease. 54(5): 429-432, 1995.
• Nakatani, S., et al. Glucosamine regulates differentiation of a chondrogenic cell line, ATDC5. Biological and Pharmaceutical Bulletin. 30(3): 433-438, 2007.
• Ohno, S., et al. Hyaluronan oligosaccharides induce matrix metalloproteinase 13 via transcriptional activation of NFkappaB and p38 MAP kinase in articular chondrocytes. Journal of Biological Chemistry. 281(26): 17952-17960, 2006.
• Poustie, M., et al. N-butyryl glucosamine increases matrix gene expression by chondrocytes. Journal of Pharmacology and Experimental Therapeutics. 311(2): 610-616, 2004.
• Sasaki, A., et al. Hyaluronate inhibits the interleukin-1beta-induced expression of matrix metalloproteinase (MMP)-1 and MMP-3 in human synovial cells. The Tohoku Journal of Experimental Medicine. 204(2): 99-107, 2004.
• Schäfer, A., et al. Inhibition of COX-1 and COX-2 activity by plasma of human volunteers after ingestion of French maritime pine bark extract (Pycnogenol®). Biomedicine and Pharmacotherapy. 60: 5-9, 2006.