nutraMetrix Isotonix OPC-3® Beauty Blend - Single Bottle (45 Servings)

nutraMetrix Isotonix OPC-3® Beauty Blend is formulated to promote skin elasticity, support healthy collagen production, replenish essential vitamins and minerals for the skin, and provide the skin and body with improved antioxidant defenses. This product helps maintain skin health at the cellular level, nourishing and rejuvenating skin cells with some of the finest antioxidants available today, including grape seed extract, red wine extract, bilberry extract, citrus bioflavanoids and Pycnogenol®. They are powerful free radical scavengers that not only work to keep the skin healthy and beautiful, but also provide free radical scavenging abilities which are beneficial in a world filled with smog, pollution and other various unseen toxins. These antioxidants are coupled with specific vitamins and minerals that are conducive to cell growth and division. Cell proliferation is important in maintaining healthy, vibrant skin.* 

nutraMetrix Isotonix OPC-3® Beauty Blend is an isotonic-capable food supplement that is made from a combination of bilberry, grape seed, red wine, pine bark extracts and citrus extract bioflavonoids, all found to be powerful antioxidants. Oligomeric proanthocyanidins (OPCs) are bioflavonoids (complex organic plant compounds) found in fruits, vegetables and certain tree barks that provide exceptional nutritional benefits to the human body. Studies have shown OPCs to be up to 20 times more powerful than vitamin C and 50 times more powerful than vitamin E in neutralizing free radicals. nutraMetrix Isotonix OPC-3 contains the only isotonic form of Pycnogenol in the world. Pycnogenol is a natural plant extract from the bark of the French maritime pine tree, and the most clinically researched and powerful bioflavonoid.

Gluten-Free - The finished product contains no detectable gluten (<10ppm gluten)

No Detectable GMOs - The finished product contains no detectable genetically-modified organisms

Vegetarian - This product is vegetarian

Isotonic-Capable Drinkable Supplements - Easy-to-swallow supplements in liquid form are immediately available to the body for absorption

Quality Standards - GMP Operations and Standardized Ingredients

Checked For: Heavy Metals, Microbiological Contaminants, Allergens, Residual Solvents, Potency, Purity and Identity

Grape Seed Extract: 25 mg
Grape seed extract is typically extracted from the seeds of red grapes (instead of white), which have a high content of compounds known as oligomeric proanthocyanidins (OPCs). Grape seed extract is extremely rich in polyphenols, compounds with high antioxidant activity. Grape seed extract has been found to maintain healthy cholesterol levels.*

Red Wine Extract: 25 mg
Red wine extract is a powerful antioxidant. This extract is found in grape vines, roots, seeds and stalks, with the highest concentration in the skins. The antioxidant properties of red wine extract contribute to maintaining healthy circulation by strengthening capillaries, arteries and veins, and promoting overall cardiovascular health.*

In the late 1990s, scientists took note of a phenomenon among the French. There were very low rates of cardiovascular problems in the provinces where residents consistently ate high fat foods and drank red wine. Scientists concluded that the protective properties of red wine have helped the French maintain cardiovascular health for years and subsequent scientific studies have further shown that the OPCs found in red wine are particularly beneficial for protecting the heart and blood vessels.*

Pine Bark Extract (Pycnogenol®): 40 mg
Pycnogenol is a natural plant extract from the bark of the maritime pine tree, which grows exclusively along the coast of southwest France in Les Landes de Gascogne. This unspoiled and natural forest environment is the unique source of pine bark. Pycnogenol is one of the most researched ingredients in the natural product marketplace. Published findings have demonstrated Pycnogenol’s wide array of beneficial effects on the body. Pine bark extract is an all natural combination of procyanidins, bioflavonoids and organic acids.

The extract has three basic properties — it is a powerful antioxidant, selectively binds to collagen and elastin, and promotes the normal production of endothelial nitric oxide, which promotes the normal dilation of dilate blood vessels.*

As one of the most powerful natural scavenger of free radicals, Pycnogenol combats many aggressive free radicals before they cause oxidative stress to vital organs. Its super-antioxidant capabilities help support healthy blood platelet activity, support healthy blood glucose levels, reduce mild menstrual cramping and abdominal pain, maintain joint flexibility, promote cardiovascular health, promote healthy sperm quality, maintain healthy cholesterol levels and support a healthy complexion.*

Bilberry Extract: 25 mg
Bilberry extract is derived from the leaves and berry-like fruit of a common European shrub closely related to the blueberry. Extracts of the ripe berry are known to contain flavonoid pigments known as anthocyanins, which are powerful antioxidants. Scientific studies confirm that bilberry extract supports healthy vision and venous circulation. Bilberry extract helps maintain healthy circulation by strengthening capillaries, arteries and veins.*

Citrus Extract (Bioflavonoids): 25 mg
Bioflavonoids are antioxidants found in certain plants that act as light filters, which protect delicate DNA chains and other important macromolecules by absorbing ultraviolet radiation. They have been found to promote cardiovascular health and help maintain healthy circulation by strengthening capillaries, arteries and veins.*

Hyaluronic Acid (Sodium Hyaluronate): 15 mg
Hyaluronic acid or hyaluronate is a glycosaminoglycan distributed widely throughout connective, epithelial and neural tissues, and is commonly used in skin care products. It is one of the main constituents of the extracellular matrix and promotes healthy cell proliferation and migration. Plentiful in extracellular matrices, hyaluronic acid supports healthy tissue hydrodynamics, movement and production of cells, and promotes a number of cell surface receptor interactions. Because hylauronic acid is found mostly in the skin and cartilage, it supports joint health. It has also been suggested that hyaluronic acid promotes healthy cartilage cells.

Hyaluronic acid may also be used to promote healing of minor tissue injuries.*

Vitamin C (Ascorbic Acid): 200 mg
Around 90 percent of vitamin C in the average American diet is derived from fruits and vegetables. Peppers (sweet, green, red and hot) are especially rich in vitamin C. Other good sources include citrus fruits and juices, brussels sprouts, cauliflower, cabbage, kale, collards, mustard greens, broccoli, spinach, guava, kiwi fruit, currants and strawberries. Nuts and grains contain very little vitamin C, and it is important to note that cooking destroys vitamin C activity. Vitamin C supports the immune system, and acts as an antioxidant. In fact, ascorbic acid may be the most important water-soluble antioxidant in the body. Vitamin C promotes the normal synthesis of collagen, promotes minor healing and helps to maintain cholesterol levels.*

Vitamin D3 (Cholecalciferol) 25 mg 
Regular sunlight exposure is the main way that most humans obtain vitamin D. Food sources of vitamin D include vitamin D-fortified milk (100 IU per cup), cod liver oil, fatty fish (such as salmon) and small amounts are found in egg yolks and liver.* Vitamin D promotes optimal blood sugar levels. Vitamin D promotes the absorption of calcium and phosphorus and supports the production of several proteins involved in calcium absorption and storage. Vitamin D works with calcium to promote bone strength. It promotes the normal transport of calcium out of the osteoblasts into the extra-cellular fluid and in the kidneys. It promotes calcium and phosphate re-uptake by renal tubules. Vitamin D also promotes the absorption of dietary calcium and phosphate uptake by the intestinal epithelium. It supports the normal growth of skin cells, and it promotes the normal production of insulin.*

Vitamin E Acetate (d-Alpha-Tocopheryl-Acetate) 22 mg
The most valuable sources of dietary vitamin E include vegetable oils, margarine, nuts, seeds, avocados and wheat germ. Safflower oil contains large amounts of vitamin E (about two thirds of the RDA in ¼ cup), and smaller amounts are found in corn oil and soybean oil. Vitamin E is actually a family of related compounds called tocopherols and tocotrienols. Vitamin E was discovered in the early 1930s. It is available in a natural or synthetic form. In most cases, the natural and synthetic form of vitamins and minerals are identical. However, the natural form of Vitamin E is superior, in terms of absorption and retention in the body.

The natural form of alpha-tocopherol, known as d-alpha tocopherol, is contained in Isotonix OPC-3 Beauty Blend. The synthetic form is the most common form found in dietary supplements. It is in the consumer's best interest to choose a product, which has opted for the more powerful (and expensive) natural form. For those individuals watching their dietary fat consumption, which is relatively common in the world of dieting, vitamin E intake is likely to be low, due to a reduced intake of foods with a higher fat content.*

The health benefits of supplemental vitamin E are derived from its properties as an immune-boosting antioxidant. Vitamin E protects cell membranes from free radical damage. It is also helpful in promoting normal wound healing and is known to help maintain a healthy cardiovascular system. Vitamin E is one of the most powerful fat-soluble antioxidants in the body. High servings of vitamin E have been shown to promote normal platelet activity.*

Biotin 150 mcg
Biotin is a part of the B-vitamin family. The B-vitamins are important co-factors, which promote the normal metabolism of fats, carbohydrates and protein. Natural food sources of biotin include egg yolk, peanuts, beef liver, milk (10 mcg/cup), cereals, almonds and Brewer's yeast. Biotin operates as an important part of several enzymes, acting as a co-enzyme implicated in energy metabolism (such as pyruvate carboxylase). In the intestines, bacteria makes a negligible amount of biotin that may be assimilated and used by the body. The main roles of Biotin include promoting strong hair and nails, increasing energy levels, helping maintain normal cholesterol levels and promoting healthy blood sugar levels.*

Calcium (Lactate) 400 mg
Calcium is found in milk, cheese, yogurt, corn tortillas, napa (Chinese cabbage), kale and broccoli. Calcium is an essential mineral with a wide range of biological roles. Calcium exists in bone, primarily in the form of hydroxyapatite (Ca10 (PO4)6 (OH)2). Hydroxyapatite comprises approximately 40 percent of the weight of bone. The skeleton has an obvious structural requisite for calcium. The skeleton also acts as a storehouse for calcium. Apart from being a major constituent of bones and teeth, calcium supports normal muscle contraction and nerve conduction, supports normal heartbeat, blood coagulation and glandular secretion, promotes the production of energy and helps maintain normal immune function.*

Calcium is essential for healthy bones and teeth. A sufficient daily calcium intake is necessary for maintaining bone density. Calcium has been shown to reduce symptoms of PMS in women. When the body does not get enough calcium per day, it draws calcium from the bones causing them to weaken. This could lead to the osteoporosis. Osteoporosis is the age-related weakening of the bones.

Calcium also may play a role in promoting cardiovascular health.*

Magnesium (Carbonate) 150 mg
Foods rich in magnesium include unpolished grains, nuts and green vegetables. Green leafy vegetables are powerful sources of magnesium because of their chlorophyll content. Meats, starches and milk are less rich sources of magnesium. Refined and processed foods are generally quite low in magnesium. The average daily magnesium intake in the U.S. for males nine years and older is estimated to be about 323 milligrams; for females nine years and older, it is estimated to be around 228 milligrams.*

Magnesium is a component of the mineralized part of bone, and it promotes the normal metabolism of potassium and calcium in adults. It helps maintain normal levels of potassium, phosphorus, calcium, adrenaline and insulin. It also promotes the mobilization of calcium, transporting it inside the cell for further utilization. It plays a key role in promoting the proper functioning of muscle and nervous tissue, and it supports the synthesis of proteins, nucleic acids, nucleotides, cyclic adenosine monophosphate, lipids and carbohydrates. Magnesium further promotes kidney and bladder health.*

Magnesium is required for release of energy, it supports normal body temperature and metabolism regulation, promotes proper nerve function, and helps the body adapt to stress. Magnesium promotes strong bones and teeth and proper muscle development. It helps the body maintain a regular heartbeat and normal blood pressure, promotes normal platelet activity and helps maintain normal cholesterol levels.*

Potassium (Bicarbonate) 97 mg
Foods rich in potassium include fresh vegetables and fruits such as bananas, oranges, cantaloupe, avocado, raw spinach, cabbage and celery.

Potassium is an essential macro-mineral that helps maintain fluid balance. It supports the normal transmission of nerve impulses, the normal contraction of cardiac, skeletal and smooth muscle, the production of energy, the synthesis of nucleic acids, the maintenance of intracellular tonicity and the maintenance of normal blood pressure. Potassium promotes normal synthesis of glycogen and protein. Potassium is an electrolyte that promotes proper heartbeat, and it supports the proper release of energy from protein, fat and carbohydrates during metabolism.*

Potassium promotes joint health and promotes the normal healing of minor cuts and bruises and other injuries, and generally contributes to a sense of well being. Potassium is stored in the muscles. Sodium and potassium are two of the most important ions in maintaining the homeostatic equilibrium of the body fluids.

• Devaraj, S., et al. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37:931-4, 2002.
• Fine, AM, Oligomeric proanthocyanidin complexes: history, structure, and phytopharmaceutical applications. Altern Med Rev 5:144-51, 2000.
• Fitzpatrick, D., et al. Endothelium-dependent vascular effects of Pycnogenol. Journal of Cardiovascular Pharmacology 32: 509-515, 1998.
• Frankel, E., et al. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 341: 454-7, 1993.
• Freedman, J., et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 103:2792-8, 2001.
• Frémont, L. Biological effects of resveratrol. Life Sciences 66: 663-673, 2000.
• Manna, S., et al. Resveratrol suppresses TNF-Induced activation of nuclear transcription factors NF-kB, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. The Journal of Immunology 164: 6509-19, 2000.
• Miyagi, Y., et al. Inhibition of human low-density lipoprotein oxidation by flavonoids in red wine and grape juice. Am J Cardiol 0:1627-31, 1997.
• Monograph. Vaccinium myrtillus (bilberry). Altern Med Rev 6:500-4, 2001.
• Murias M., et al. Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship. , 2004.
• Nuttall SL, Kendall MJ, Bombardelli E, Morazzoni P. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm Ther 23: 385-89, 1998.
• Packer, L., et al. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 27:704-24, 1999. Review.
• Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol ® ), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40:158-68, 2002. Review.
• Rohdewald, P. Pycnogenol ® . In “Flavonoids in Health and Disease”. Ed. Catherine Rice-Evans and Lester Packer. New York: Marcel Dekker, Inc., 1998. 405-19.
• Schönlau, F., et al. The cosmeceutical Pycnogenol ® . J Appl Cosmetology 20: 241-6, 2002.
• Segger, D. and Schönlau, F. Supplementation with Evelle ® improves skin smoothness and elasticity in a double blind, placebo-controlled study with 62 women. Journal of Dermatological Treatment 15:222-26, 2004.
• Shi, J., et al. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6:291-9, 2003. Review.
• Wallerath, T., et al. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 106:1652-8, 2002.
• Watson, R. Pycnogenol ® and cardiovascular health. Evidence-Based Integrative Medicine 1: 27-32, 2003.
• Bagchi, D, et al. Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro. Res Commun Mol Pathol Pharmacol 95:179-89, 1997.
• Cao G, Alessio H, Cultler R. Oxygen-radical absorbance capacity assay for antioxidants. Fre Rad Biol & Med 14:301-11, 1993.
• Drew B, Leeuwenburgh C. Aging and the role of reactive nitrogen species. Ann NY Acad Sci 959:66-81, 2002.
• Graham DY, Smith JL, Bouvet, AA. What happens to tablets in the stomach. J Pharm Sci 79:420-24, 1990.
• Havsteen B. Flavonoids, a class of natural products of high pharmacological potency. Biochem Pharm 32:1141-48, 1983.
• Koparker AD, Augsburger LL, Shangraw RF. Intrinsic dissolution rates of tablet fillers and binders and their influence on the dissolution of drugs from tablet formulations. Pharm Res 7:80-85, 1990.
• Mazza G, Kay CD, Cottrell T, Holub BJ. Absorption of anthocyanins from blueberries and serum antioxidant status in human subjects. J Agric Food Chem 50:7731-37, 2002.
• Rimbach G, Virgili F, Park YC, Packer L. Effect of procyanidins from Pinus maritime on glutathione levels in endothelial cells challenged by 3-morpholinosydnonimine or activated macrophages. Redox Rep 4:171-77, 1999.
• Soloway MS, Smith RA. J Am Med Assoc 260:1465, 1988.
• Zheng W, Wang SY. Oxygen radical absorbing capacity of phenolics in blueberries, cranberries, chokeberries, and lingonberries. J Agric Food Chem 51:502-9, 2003.