The Gene SNP™ Foundation Bundle Pro - Includes five products

nutraMetrix Isotonix Activated B-Complex

Methylcobalamin (Vitamin B12) (120 mcg)
Vitamin B12 (cobalamin) is a bacterial product naturally found in animal products, especially organ meats, such as liver, with small amounts derived from peanuts and fermented soy products, such as miso and tempeh. It is essential that vegetarians consume a vitamin B12 supplement to maintain optimal health. Vitamin B12, when ingested, is stored in the liver and other tissues for later use. It supports the maintenance of cells, especially those of the nervous system, bone marrow and intestinal tract. Vitamin B12 is important in homocysteine metabolism (homocysteine is an amino acid that is formed within the body). Normal homocysteine levels are important for maintaining cardiovascular health. Deficiencies of the vitamins folic acid, pyridoxine (B6) or cobalamin (B12) can result in elevated levels of homocysteine. Folate and B12, in their active coenzyme form, are both necessary cofactors for the conversion of homocysteine to methionine, thus helping to maintain healthy blood levels of homocysteine.

Methylcobalamin is one of the naturally-occurring forms of vitamin B12 found in the human body. The liver must convert cyanocobalamin, the form of B12 most commonly used in supplements, into methylcobalamin, before it can be properly utilized by the body; methylcobalamin is more effective than non-active forms of vitamin B12. Methylcobalamin also assists in the formation of SAMe (S-adenosylmethionine), a nutrient that has powerful mood-elevating properties.

Folate [as (6S)-5-methyltetrahydrofolic acid, glucosamine salt, Quatrefolic®] (432 mcg) 
Folic acid plays a key role by boosting the benefits of B12 supplementation. These two B vitamins join forces and work together in maintaining normal red blood cells. Folic acid assists in the normal utilization of amino acids and proteins, as well as supporting the construction of the material for DNA and RNA synthesis, which is necessary for all bodily functions. Scientific studies have found that when working in tandem with folic acid, B12 is capable of promoting normal homocysteine levels. This works toward supporting a healthy cardiovascular and nervous system.

Folic acid must go through conversion into 5-methyltetrahydrofolate (5-MTHF) – the active form of folate – before it becomes metabolically active for the body to use. The enzyme methylenetetrahydrofolate reductase (MTHFR) assists in that process. However, some people have a genetic variation where their bodies do not adequately produce MTHFR.

Quatrefolic® is the glucosamine salt of (6S)-5-methyltetrahydrofolate and is structurally analogous to the reduced and active form of folic acid. Because this form is naturally present in the body, it is much more bioavailable for its biological action without having to be metabolized in the body. This patented ingredient also provides greater sfont-style: italic;">Quatrefolic® is a registered trademark of Gnosis S.p.A. and is protected by U.S. patent No. 7,947,662.

Riboflavin-5-Phosphate (Vitamin B2) (3 mg)
Vitamin B2 is found in liver, dairy products, dark green vegetables and some types of seafood. Vitamin B2 serves as a coenzyme, working with other B vitamins. It promotes healthy red blood cell formation, supports the nervous system, respiration, antibody production and normal human growth. It supports healthy skin, nails, hair growth and promotes normal thyroid activity (a healthy thyroid is essential in maintaining a healthy weight, among other things). Vitamin B2 supports the body's ability to turn food into energy as a part of the electron transport chain, driving cellular energy on the micro-level. Riboflavin can be useful for pregnant or lactating women, as well as athletes due to their higher caloric needs. Vitamin B2 also promotes the normal breakdown of fats. Vitamin B2 is water-soluble and cannot be stored by the body except in insignificant amounts. It must be replenished daily.

Pyridoxal-5-Phosphate (Vitamin B6) (6 mg)
Poultry, fish, whole grains and bananas are the main dietary sources of vitamin B6. B6 is a co-factor required for protein and amino acid metabolism, and helps maintain proper fluid balance. It also assists in the maintenance of healthy red and white blood cells, which keeps our body healthy. Vitamin B6 promotes normal hemoglobin synthesis (hemoglobin is the protein portion of red blood cells which carries oxygen throughout the body). Because vitamin B6 is involved in the synthesis of neurotransmitters in the brain and nerve cells, it has been recommended as a nutrient to support mental function, specifically mood. Athletic supplements often include vitamin B6 because it promotes the conversion of glycogen to glucose for energy in muscle tissue. Vitamin B6, when taken with folic acid, has been shown to help maintain normal plasma levels of homocysteine, which promotes optimal cardiovascular health. Vitamin B6 should be administered as a part of a complex of other B vitamins for best results.

Magnesium (Carbonate) (40 mg)
Foods rich in magnesium include unpolished grains, nuts and green vegetables. Green, leafy vegetables are potent sources of magnesium because of their chlorophyll content. Meats, starches, milk, refined and processed foods contain low amounts of magnesium. Recent research shows that many American diets are magnesium deficient.

Magnesium is a component of the mineralized part of bone, and promotes the normal metabolism of potassium and calcium in adults. It helps maintain normal levels of potassium, phosphorus, calcium, adrenaline and insulin. It also supports the transportation of calcium inside the cell for utilization. Magnesium promotes the normal functioning of muscle and nervous tissue, and the synthesis of all proteins, nucleic acids, nucleotides, fats and carbohydrates.

Magnesium supports the normal release of energy from food during metabolism, regulation of body temperature, proper nerve function and helping the body handle stress. Importantly, magnesium also promotes healthy bones, teeth and normal muscle development. It works together with calcium and vitamin D to promote strong bones. Magnesium, when combined with calcium, helps support the heart muscle in maintaining a regular heartbeat and promoting normal blood pressure.

Potassium (Bicarbonate) (94 mg)
Potassium is an electrolyte stored in the muscles. Foods rich in potassium include bananas, oranges, cantaloupe, avocado, raw spinach, cabbage and celery. Potassium is an essential macromineral that helps maintain fluid balance in the body. It also plays a role in a wide variety of biochemical and physiological processes. Among other things, potassium promotes the transmission of nerve impulses, the contraction of cardiac, skeletal and smooth muscle, the production of energy, the synthesis of nucleic acids and the maintenance of normal blood pressure.

In 1928, it was first suggested that high potassium intake could help maintain cardiovascular health. Potassium promotes normal muscle relaxation and helps maintain normal insulin release. It also promotes glycogen and protein synthesis. Potassium is an electrolyte that promotes normal heartbeat. Potassium promotes the normal release of energy from protein, fat and carbohydrates during metabolism. Potassium helps maintain normal water balance, supports recovery from exercise and the elimination of wastes. Sodium and potassium are two of the most important ions in maintaining the homeostatic equilibrium of the body fluids.

Thiamin HCl (Vitamin B1) (2 mg)
Thiamin promotes normal carbohydrate metabolism and nerve function. Thiamin is required for a healthy nervous system, and supports the production of certain neurotransmitters which have an important role in muscle function. It supports the digestive process, increases energy and helps promote mental clarity.

D-Calcium Pantothenate (Vitamin B5) (20 mg)
Pantothenic acid (B5) promotes proper neurotransmitter activity in the brain. Pantothenic acid is also known as the anti-stress vitamin because it helps relieve physical and emotional stress, and promotes the secretion of hormones essential for optimal health.

Niacinamide (Vitamin B3) (20 mg)
Niacin is a water-soluble vitamin necessary for many aspects of health, growth and reproduction. Niacin supports the proper functioning of the digestive system, skin and nerves. It promotes the conversion of food to energy. Niacin is found in dairy products, poultry, fish, lean meats, nuts, eggs, legumes, and enriched breads and cereals.

Biotin (Vitamin B7) (300 mcg)
Biotin can be found in food sources, such as egg yolks, peanuts, beef liver, milk, cereals, almonds and Brewer’s yeast. Biotin promotes healthy cell growth, the production of fatty acids, metabolism of fats and amino acids. It supports the citric acid cycle, which is the process in which energy is generated during exercise. Biotin is also helpful in maintaining steady blood sugar levels. Biotin is often recommended for maintaining strong hair and nails.

These 10 ingredients, combined with the superior delivery of Isotonix®, create a powerhouse B vitamin product superior to the rest on the market. Isotonix Activated B-Complex delivers all of the B vitamins along with select minerals and electrolytes to help boost energy, decrease stress, improve mood, and much more. The activated forms of select vitamins ensure maximal utilization by the body for optimal results.

nutraMetrix Isotonix Magnesium

Magnesium (Citrate & Glycinate) 400 mg
Magnesium is a component of the mineralized part of bone and supports the normal metabolism of potassium and calcium in adults. It helps maintain normal levels of potassium, phosphorus, calcium, adrenaline and insulin. It also promotes the normal mobilization of calcium, transporting it inside the cell for further utilization. It plays a key role in supporting the normal functioning of muscle and nervous tissue.

Magnesium promotes the normal synthesis of all proteins, nucleic acids, nucleotides, cyclic adenosine monophosphate, lipids and carbohydrates. Magnesium is required for release of energy and it promotes the normal regulation of body temperature and proper nerve function, it helps the body handle stress, and it promotes a healthy metabolism. Magnesium works together with calcium to help maintain the normal regulation of the heart and blood pressure. Importantly, magnesium also supports the body’s ability to build healthy bones and teeth, and promotes proper muscle development. It works together with calcium and vitamin D to help keep bones strong. Magnesium also promotes cardiovascular health by supporting normal platelet activity and helping to maintain normal cholesterol levels.

Potassium (Bicarbonate) 150 mg
Potassium is an electrolyte stored in the muscles. Foods rich in potassium include bananas, oranges, cantaloupe, avocado, raw spinach, cabbage and celery. Potassium is an essential macromineral that helps maintain fluid balance in the body. It also supports a wide variety of biochemical and physiological processes.

Among other things, potassium supports the normal transmission of nerve impulses, contraction of cardiac, skeletal and smooth muscle, synthesis of nucleic acids, maintenance of intracellular tonicity and maintenance of normal blood pressure. In 1928, it was first suggested that high potassium intake could help maintain cardiovascular health. Potassium supports normal muscle relaxation and insulin release. It also promotes glycogen and protein synthesis. Potassium is an electrolyte that promotes normal heartbeat. Potassium supports the body’s ability to regulate water balance, recover from exercise and eliminate wastes.

nutraMetrix Isotonix Daily Essentials - Anti Aging

nutraMetrix Heart Health Essential Omega III Fish Oil with Vitamin E

Fish Body Oils 3000 mg [EPA† 900 mg and DHA† 600 mg]
Fish oils or marine oils are lipids (fats) found in fish, particularly cold water fish like herring, kipper, mackerel, menhaden, pilchard, salmon, sardine and trout, and phytoplankton. The sources of fish oil in Heart Health™ Omega III Fish Oil are sardines and anchovies, tested by the manufacturer and an independant testing company to be virtually free of mercury lead, PCB and other heavy metals. Fish oils are rich sources of omega-3 long-chain polyunsaturated fatty acids. EPA (eicosapentaenoic acid) and DHA (docosahexanenoic acid) are the two most studied fish oils. DHA is a necessary component of the phospholipids in human cellular membranes, especially those found in the brain and retina. Clinical studies have shown omega-3 fatty acids to help maintain healthy triglyceride levels. A strong correlation has also been shown between fish oil consumption and the ability to maintain healthy levels of C-reactive protein. Fish oils are also important in the maintenance of normal blood flow, as they support normal fibrinogen levels (coagulation or blood clotting), which contributes to normal platelet activity.

EPA and DHA have several mechanisms of action to help maintain normal triglyceride and cholesterol levels, help maintain normal blood flow and pressure, and support normal platelet activity. EPA and DHA help maintain normal triglyceride levels by promoting normal lipogenesis and supporting normal fatty acid oxidation in the liver. EPA and DHA promote the normal transcription of genes coding for lipogenesis enzymes and promote the normal transportation of the regulatory enzymes of fatty acid oxidation. Activating PPAR (peroxisome proliferator-activated receptor) - alpha, helps to support normal fatty acid oxidation. The promotion of normal lipogenesis is done through down-regulation of SREBP (sterol regulatory element binding protein) -1c messenger RNA.

EPA is the precursor to series-3 prostaglandins (PG), the series-3 thrombaxanes (TX) and the series-5 leukotrienes (LT). More specifically, EPA is a precursor to eicosanoids (TXA3 and LTB5), which promote normal platelet activity and promote normal vasodilation. These effects demonstrate EPA’s potential ability to help maintain normal blood pressure and support normal blood clotting. Fish oils inhibit the arachidonic acid synthesis of thromboxane A2, which help to promote normal platelet activity and vasodilation. Fish oil may also contribute to the normal production of prostacyclin, a prostaglandin that promotes normal vasodilation and supports normal platelet activity.

Omega-3 fatty acids compete metabolically with omega-6 fatty acids, found in higher amounts in typical western diets. Omega-6 fatty acids may inhibit the incorporation of omega-3 fatty acids into tissue lipids. Omega-3 fatty acids may inhibit the conversion of many omega-6 fatty acids into arachidonic acid. Consumption of omega-3 fatty acids DHA and EPA, a corresponding increase of these fatty acids appears to occur in cell membranes and circulatory lipids along with a simulataneous reduction in omega-6 fatty acids.

Vitamin E (d-alpha tocopherol) 23 IU
The most valuable sources of dietary vitamin E include vegetable oils, margarine, nuts, seeds, avocados and wheat germ. Safflower oil contains large amounts of vitamin E (about two thirds of the RDA in ¼ cup), and there are trace amounts in corn oil and soybean oil. Vitamin E is actually a family of related compounds called tocopherols and tocotrienols. Vitamin E is available in a natural or synthetic form. In most cases, the natural and synthetic forms are identical except the natural form of vitamin E is better absorbed and retained in the body. The natural form of alpha-tocopherol is known as "d-alpha tocopherol." The synthetic "dl-" form is the most common form found in dietary supplements. For those individuals watching their dietary fat consumption, which is relatively common in the world of dieting, vitamin E intake is likely to be low, due to a reduced intake of foods with high fat content.

The main health benefit of supplemental vitamin E comes from its immune-boosting antioxidant activity. It supports a healthy cardiovascular system. Vitamin E is one of the most powerful fat-soluble antioxidants in the body. In turn, vitamin E protects cell membranes from free radical. Vitamin E is commonly added to fish oil supplements to provide antioxidant protection of DHA and EPA.

†According to the FDA, supportive, but not conclusive, research shows that consumption of EPA and DHA omega-3 fatty acids may reduce the risk of coronary heart disease.

nutraMetrix Curcumin Extreme

Curcugreen™^† (Curcuma longa rhizome standardized to 88% curcuminoids^‡ and essential oils): 400 mg
Curcugreen™^†is a branded curcumin ingredient made from turmeric extract which contains a proprietary blend of curcuminoids and turmeric oils. Though most curcumins have poor bioavailability, Curcugreen offers a high level of oral bioavailability in order for the body to reap the full spectrum of health benefits curcumin can provide.

Curcumin is the main active ingredient in turmeric. Turmeric, used historically for health and cosmetic purposes, as well as a fabric dye and a culinary spice, comes from the Curcuma longa plant. Curcumin, in and of itself, has also been used to support health and for cooking. Presently the science community has shown an interest in learning more about curcumin and its possible benefits. 

In studies, curcumin has shown evidence of being able to support immune, cognitive and liver health. It also appears to boast antioxidant properties and to protect the body from free radicals. Curcumin has been shown to support the production of enzymes for glutathione and its synthesis, as well as metabolism.₂ Glutathione is produced naturally by the body and has antioxidant properties.

In addition to its immune-supporting activity, curcumin has been shown to support normal Cyclooxygenase-2 (COX-2) and NF-kappaB (NF-kB) levels in the body through multiple mechanisms. NF-kB is a transcription factor, meaning that it functions to support the normal formation of a specific protein encoded by a gene – specifically the COX-2 gene.₃

Curcumin has been shown to help maintain neurological health and cognitive function. Curcumin may help by promoting healthy levels of amyloid-β protein (a protein fragment) in the brain. In recent studies, researchers have linked normal levels of amyloid-β protein to neurological and cognitive health, such as memory and mood. Another neuroprotective property of curcumin is its ability to promote normal levels of glutathione, superoxide dismutase (SOD) and catalase in the brain, which can help maintain the health of neurological tissues. SOD and catalase are enzymes that protect cells.

Curcumin supports liver health and its functions. In studies, curcumin has shown to support the normal production of phase II detoxification enzymes in the liver. These detoxification enzymes promote the body’s natural defense systems and function as powerful indirect antioxidants, helping to neutralize harmful heavy metals, toxins and pollutants. For example, curcumin’s support of glutathione synthesis supports the detoxification function of glutathione transferase. Curcumin also promotes normal liver tissue.

^†Curcugreen™ is a trademark of Arjuna Natural Ltd.

^‡Curcuminoids are compounds in the spice, turmeric. One of these compounds is curcumin, which is the main active ingredient.

Broccoli Seed Extract (4.5% Glucosinolates): 223 mg
The health benefits and protective properties of broccoli and other cruciferous vegetables are well known and supported.  Broccoli seed extract is a powerful source of sulforaphane. Sulforaphane supports the normal production of phase II detoxification enzymes, which promotes the body’s normal metabolism of chemicals and toxins. Sulforaphane also promotes the body’s natural defense systems and functions as a powerful indirect antioxidant – meaning it supports the ability of antioxidants that directly protect the body from oxidative stress.

Sulforaphane works to maintain healthy levels of glutathione. Known by scientists as the master antioxidant, glutathione is one of the body’s key antioxidants, and serves as a protector from free radicals and other toxins. Glutathione is also capable of recycling other antioxidants, and supporting immune health and healthy detoxification among other things.

Indole-3-carbinol (I3C), a product of glucosinolates present in cruciferous vegetables, is known to support normal mast cell genesis. One important health benefit of I3C is its ability to induce apoptosis and suppress free-radical production. Numerous studies have indicated that I3C also has strong hepato-protective activity

Selenium (L-Selenomethionine): 100 mcg 
L-Selenomethionine provides a bioavailable form of selenium. It uses the same active transport mechanism as for methionine, one of the 9 essential amino acids that can only be obtained from the diet, and this increases the efficiency of absorption of selenomethionine over inorganic forms of selenium. Selenium is an essential mineral that is important for the proper functioning of many body processes. This essential element is a required component of the selenoproteins, which includes those that are needed to convert thyroid hormones from the inactive to the active form, and several important antioxidants. As an antioxidant, it helps control free radicals and reduce oxidative stress. Selenium is a required cofactor for glutathione peroxidase (neutralizes hydrogen peroxide) and studies show it may help to increase levels of this antioxidant enzyme. In addition to promoting healthy levels of glutathione, selenium also promotes neurological health and a strong immune system.