Why Choose The Methylator Bundle*
Methylation is essentially turning on/off certain cellular pathways within our bodies. For people who don’t methylate well, supplementing to drive appropriate enzymatic function can support the metabolic pathways to help maintain immune function, promote the body’s ability to detox and help maintain healthy neurologic function.
THE METHYLATOR BUNDLE - INCLUDES FIVE PRODUCTS
Quantity of one each:
Frequently Asked Questions*
What is methylation and why is it important?
The body is like a machine with many switches, switches that help regulate biochemical activity within the body. One such activity, methylation, affects our cellular energy, metabolism of fat, and detoxification, to name a few. Ensuring proper methylation is vital for optimal health. Methylation is a chemical process that can either turn a gene, enzyme, or receptor on or off. Methylation affects the body’s natural detoxification process, controlling oxidation, immune function, including autoimmunity, formation of neurotransmitters, energy production, inflammation and a host of other critical functions. These areas of impact are a concern for individuals who under methylate as well as over methylate. The select nutrients in the Methylator Bundle were chosen with both scenarios in mind.
What makes nutraMetrix Isotonix® Activated B-Complex product unique?
A certain percentage of the population – possibly as high as 30% – is unable to metabolize the un-methylated forms of specific B vitamins, namely Folate and Vitamin B12. The active forms of these B vitamins are referred to as the methylated form.
nutraMetrix Isotonix Activated B-Complex delivers metabolically active forms of several vitamins and minerals. This is important because traditional forms of vitamins B6, B12 and folic acid found in most other B-complex products must undergo chemical changes in order to be utilized by the body. Several factors including age and nutritional status may decrease the body’s ability to activate these vitamins. By providing the metabolically active forms of these vitamins in isotonic form, you can be certain that your body is getting the vital nutrients it needs quickly and effectively.* One example of this is Quatrefolic®†. Quatrefolic® is the glucosamine salt of 5-methyltetrahydrofolate and has the same structure and activity of the reduced and active form of folic acid. This is especially beneficial to the nearly 1/3 of the population who genetically cannot make this active form. Activated folic acid assists in the normal utilization of amino acids and proteins, as well as supporting the construction of the material for DNA and RNA synthesis, which is necessary for all bodily functions. The use of the active nutrients improves overall availability to the body of the needed nutritional base your body requires.
Wilcken B, Bamforth F, Li Z, et alGeographical and ethnic variation of the 677C>T allele of 5,10 methylenetetrahydrofolate reductase (MTHFR): findings from over 7000 newborns from 16 areas world wideJournal of Medical Genetics 2003;40:619-625.
Why are B vitamins so important in the supporting healthy cognition and the aging process?
The ability to absorb B vitamins naturally decreases with age, and healthy cognitive function is associated with normal B vitamin levels. According to Robert M. Russell of the U.S. RDA’s Human Nutrition Center on Aging at Tufts University, vitamin B12 is probably the single most important nutrient adversely affected by aging. Vitamin B12 is a difficult nutrient to digest and assimilate, as well as one of the most important vitamins supporting a broad range of functions, including s normal energy production and nervous system function.
Magnesium and Methylation
Magnesium is one of the most important nutrients in health; it is required for over 300 reactions that take place in the body and one of the ways magnesium exerts such a powerful role in so many facets of overall health is due to its role in methylation.
Our genetic makeup determines how well we methylate. People with methylation concerns may require extra nutrients such as magnesium to help support the methylation cycle.
Magnesium is a cofactor in many different areas of the methylation cycle, such as:
MTHFS – this gene produces methenyltetrahydrofolate synthetase, which supports the folate cycle, a process critical to the workings of each cell in the body. (2)
COMT – Catechol-o-methyltransferase plays a major role in regulating our neurotransmitters such as dopamine and our adrenalines, epinephrine and norepinephrine. (3)
For therapeutic purposes, the type of magnesium is crucial to its delivery to the appropriate tissue and for its efficacy in supporting people’s health.
Why were these forms of magnesium (citrate and glycinate) chosen?
Both of these forms of magnesium were carefully chosen based on the latest scientific rationale, as they have been shown to have excellent oral absorption rates and work well within the Isotonix® delivery system.
Why do I need a magnesium supplement versus getting it from my normal diet?
Daily lifestyle factors and poor dietary choices adversely affect the amount of magnesium we are ingesting. Foods rich in magnesium include whole grains, nuts and green vegetables. Refined and processed foods – which make up a large portion of the typical diet in today’s society – contain low amounts of magnesium. Even with a proper, balanced diet, the amount of nutrients in foods today vastly differs from those of even a generation ago. In addition, food preparation methods may decrease the magnesium content of food. For these reasons, it is important to help balance our diets with nutritional supplements that can provide additional nutritional assistance.
Why was Turn Up chosen for the Methylator Bundle?
Turn Up combines nutrients that support mental clarity and focus as well as energy metabolism and essential amino acids to support mental stamina. Ingredients like mangosteen and acai are two of the carefully selected ingredients because of their xanthione content. Xanthone compounds in mangosteen (Garcinia mangostana Linn.) fruit have been reported to have antioxidant properties. Xanthones help support sustained energy, because they use fatty acids for energy, which will help maintain physical and mental energy throughout the day. (1)
1-Distribution of major xanthones in the pericarp, aril, and yellow gum of mangosteen (Garcinia mangostana linn.) fruit and their contribution to antioxidative activity. Biosci Biotechnol Biochem. 2013;77(5):984-7. Epub 2013 May 7.
2- Multifunctional Effects of Mangosteen Pericarp on Cognition. Evidence Based Complement Alternative Med. 2014;2014:813672. doi: 10.1155/2014/813672. Epub 2014 Dec 1.
Why are probiotics in this regimen?
Increasingly, research has indicated that gut microbiota — the trillions of microorganisms in the gut which perform important functions in the immune system and metabolism by providing essential nutrients and vitamins — support the normal regulation of brain function through something called the “gut-brain axis.”
People who are looking to support their mental health might benefit from taking steps to support the balance of the microorganisms in their gut using probiotic and non-probiotic food and supplements.
Recent research also suggests that mental/emotional wellbeing could be healthfully supported by regulating the intestinal microbiota. In one such study published in Frontiers in Psychiatry the findings suggested that improving mood by means of probiotics intake might additionally reduce sensitivity to negative situations, as support our ability to deal with them.
Aging Neurosci., 10 November 2016; Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer's Disease: A Randomized, Double-Blind and Controlled Trial
Nikolova V, Zaidi SY, Young AH, Cleare AJ, Stone JM. Gut feeling: randomized controlled trials of probiotics for the treatment of clinical depression: Systematic review and meta-analysis. Ther Adv Psychopharmacol. 2019;9:2045125319859963. Published 2019 Jun 26. doi:10.1177/2045125319859963
Yang B, Wei J, Ju P, Chen J. Effects of regulating intestinal microbiota on anxiety symptoms: A systematic review. Gen Psychiatr. 2019;32(2):e100056. Published 2019 May 17. doi:10.1136/gpsych-2019-100056
There are many components that affect a healthy gut barrier, such as enzymes, pH conditions, bile from the gall bladder, intestinal microflora, probiotics and even some properties contained in consumed food. In addition to diet, supplementing your intestines with probiotics can help support the gut microbiota by balancing intestinal microflora in the body. The human gut microbiota is composed of many different bacteria families.
Researchers have found that probiotic supplements with more diverse strain profiles are more effective in helping to balance the intestinal microbiota.
Marotta A et al. “Effects of probiotics on cognitive reactivity, mood, and sleep quality.” Frontiers in Psychiatry, vol. 10 (2019)
“Effects of regulating intestinal microbiota on anxiety symptoms: A systematic review”. Beibei Yang, Jinbao Wei, Peijun Ju, Jinghong Chen. General Psychiatry. doi:10. 1136/gpsych-2019-100056
nutraMetrix Bliss contains herbal ingredients like L-theanine that have shown in studies to help relax or reduce stress without the side effect of drowsiness.
GABA (gamma-aminobutyric acid) is a nutrient that promotes feelings of calm and helps the brain maintain healthy levels of the neurotransmitters epinephrine and norepinephrine.
As a neurotransmitter, serotonin (5-hydroxytryptamine) plays a key role in the central nervous system and digestive system as it sends messages and signals between nerve cells. In the brain, extensive research suggests serotonin is heavily involved in mood regulation. Also known as the “happy” or “feel-good” brain chemical, when serotonin levels are low, many people experience poor or imbalanced mood symptoms. When serotonin levels are healthy, people are more likely to experience calmer, more focused and stable moods.
Like serotonin, dopamine is a neurotransmitter. Research shows dopamine to have several functions in the brain, including its effect on a person’s feelings of reward and motivation, memory, attention and body movement. Low levels of dopamine in the body have shown to alter mood, reducing feelings of motivation and enthusiasm.
What do these select nutrients have to do with methylation?
Individuals with diminished methylation enzymes often have low mood and low energy due to the negative effect that diminished methylation can have on levels of neurotransmitters. nutraMetrix Bliss® Anti-Stress Formula contains a special blend of ingredients with adaptogenic qualities that help manage the negative effects of stress. This formula not only works to relax and balance the body and mind, it does so without promoting drowsiness.
Panossian, A. and Wikman, G. Effects of Adaptogens on the Central Nervous System and the Molecular Mechanisms Associated with Their Stress—Protective Activity. Pharmaceuticals, 3(188-224), 2010. doi:10.3390/ph3010188
Scaccia, A. (2017, May 18). Serotonin: What You Need to Know. Retrieved from https://www.healthline.com/health/mental-health/serotonin
Julson, E. (2018, May 10). 10 Best Ways to Increase Dopamine Levels Naturally. Retrieved from https://www.healthline.com/nutrition/how-to-increase-dopamine
Ruhoy, I. (2018, October 25). GABA: Here's How It Works In Your Brain + Why It's So Important. Retrieved from https://www.mindbodygreen.com/articles/gaba-what-is-it
University Health News. (2013). 4 GABA Deficiency Symptoms You Can Identify Yourself. Retrieved from https://universityhealthnews.com/daily/depression/4-gaba-deficiency-symptoms-you-can-identify-yourself/
National Institute of Mental Health. 5 Things You Should Know About Stress [PDF]. Retrieved from https://www.nimh.nih.gov/health/publications/stress/5thingsshldknowaboutstress-508-03132017_142898.pdf
†Quatrefolic® is a registered trademark of Gnosis S.p.A.
Additional Bundles Offered
Optimizing Your Genetic Environment – 5 Important Considerations
1. There isn’t one Superstar Gene – a healthy gene environment is not influenced by just one gene, but how all your genes interact with each other. Knowing your personal gene story will help provide the information needed to create an optimal gene environment.
2. Gene pathways – Your genetic expression may take one of three pathways:
- Optimal gene potential – pathways to “turn up” or optimize;
- Alternative – pathways needing a different combination/form of nutrient composition to support a unique gene environment or “turn down”;
- arrested or low/non-functioning – pathways to support or redirect.
3.One size does not fit all – because your gene story is unique, a health program should be personalized and tailored to the needs of your body. Your nutraMetrix Health Professional could help you by performing a Gene SNP DNA Analysis that will show gene variations and what components should be targeted.
4. Gene environment is influenced by more than nutrients – although nutrients are an essential component in optimizing your gene environment, maintaining an active lifestyle can significantly regulate gene environment. Sleep and stress management must be addressed to maximize your genetic potential. Nutrients and supplementation can help maximize your fitness, sleep, and stress/balance potential.
5. Combination is key – Because there is no one “master” promoter of health or optimized gene environment, it is vital to have a combination of different components, such as:
- Physical Fitness
- Optimized Sleep
- Stress Balance
- Select nutrients, fatty acids and antioxidants
Focusing on one component will not have a significant impact on your health. It takes a commitment to exercise, getting the proper amount of sleep, managing stress, as well as the nutrients you eat and supplements you take to create your optimal gene environment.
Key Ingredients Found In The Methylator Bundle*
nutraMetrix Isotonix Activated B-Complex
Methylcobalamin (Vitamin B12) (120 mcg)
Vitamin B12 (cobalamin) is a bacterial product naturally found in animal products, especially organ meats, such as liver, with small amounts derived from peanuts and fermented soy products, such as miso and tempeh. It is essential that vegetarians consume a vitamin B12 supplement to maintain optimal health. Vitamin B12, when ingested, is stored in the liver and other tissues for later use. It supports the maintenance of cells, especially those of the nervous system, bone marrow and intestinal tract. Vitamin B12 is important in homocysteine metabolism (homocysteine is an amino acid that is formed within the body). Normal homocysteine levels are important for maintaining cardiovascular health. Deficiencies of the vitamins folic acid, pyridoxine (B6) or cobalamin (B12) can result in elevated levels of homocysteine. Folate and B12, in their active coenzyme form, are both necessary cofactors for the conversion of homocysteine to methionine, thus helping to maintain healthy blood levels of homocysteine.
Methylcobalamin is one of the naturally-occurring forms of vitamin B12 found in the human body. The liver must convert cyanocobalamin, the form of B12 most commonly used in supplements, into methylcobalamin, before it can be properly utilized by the body; methylcobalamin is more effective than non-active forms of vitamin B12. Methylcobalamin also assists in the formation of SAMe (S-adenosylmethionine), a nutrient that has powerful mood-elevating properties.
Folate [as (6S)-5-methyltetrahydrofolic acid, glucosamine salt, Quatrefolic®] (432 mcg)
Folic acid plays a key role by boosting the benefits of B12 supplementation. These two B vitamins join forces and work together in maintaining normal red blood cells. Folic acid assists in the normal utilization of amino acids and proteins, as well as supporting the construction of the material for DNA and RNA synthesis, which is necessary for all bodily functions. Scientific studies have found that when working in tandem with folic acid, B12 is capable of promoting normal homocysteine levels. This works toward supporting a healthy cardiovascular and nervous system.
Folic acid must go through conversion into 5-methyltetrahydrofolate (5-MTHF) – the active form of folate – before it becomes metabolically active for the body to use. The enzyme methylenetetrahydrofolate reductase (MTHFR) assists in that process. However, some people have a genetic variation where their bodies do not adequately produce MTHFR.
Quatrefolic® is the glucosamine salt of (6S)-5-methyltetrahydrofolate and is structurally analogous to the reduced and active form of folic acid. Because this form is naturally present in the body, it is much more bioavailable for its biological action without having to be metabolized in the body. This patented ingredient also provides greater sfont-style: italic;">Quatrefolic® is a registered trademark of Gnosis S.p.A. and is protected by U.S. patent No. 7,947,662.
Riboflavin-5-Phosphate (Vitamin B2) (3 mg)
Vitamin B2 is found in liver, dairy products, dark green vegetables and some types of seafood. Vitamin B2 serves as a coenzyme, working with other B vitamins. It promotes healthy red blood cell formation, supports the nervous system, respiration, antibody production and normal human growth. It supports healthy skin, nails, hair growth and promotes normal thyroid activity (a healthy thyroid is essential in maintaining a healthy weight, among other things). Vitamin B2 supports the body's ability to turn food into energy as a part of the electron transport chain, driving cellular energy on the micro-level. Riboflavin can be useful for pregnant or lactating women, as well as athletes due to their higher caloric needs. Vitamin B2 also promotes the normal breakdown of fats. Vitamin B2 is water-soluble and cannot be stored by the body except in insignificant amounts. It must be replenished daily.
Pyridoxal-5-Phosphate (Vitamin B6) (6 mg)
Poultry, fish, whole grains and bananas are the main dietary sources of vitamin B6. B6 is a co-factor required for protein and amino acid metabolism, and helps maintain proper fluid balance. It also assists in the maintenance of healthy red and white blood cells, which keeps our body healthy. Vitamin B6 promotes normal hemoglobin synthesis (hemoglobin is the protein portion of red blood cells which carries oxygen throughout the body). Because vitamin B6 is involved in the synthesis of neurotransmitters in the brain and nerve cells, it has been recommended as a nutrient to support mental function, specifically mood. Athletic supplements often include vitamin B6 because it promotes the conversion of glycogen to glucose for energy in muscle tissue. Vitamin B6, when taken with folic acid, has been shown to help maintain normal plasma levels of homocysteine, which promotes optimal cardiovascular health. Vitamin B6 should be administered as a part of a complex of other B vitamins for best results.
Magnesium (Carbonate) (40 mg)
Foods rich in magnesium include unpolished grains, nuts and green vegetables. Green, leafy vegetables are potent sources of magnesium because of their chlorophyll content. Meats, starches, milk, refined and processed foods contain low amounts of magnesium. Recent research shows that many American diets are magnesium deficient.
Magnesium is a component of the mineralized part of bone, and promotes the normal metabolism of potassium and calcium in adults. It helps maintain normal levels of potassium, phosphorus, calcium, adrenaline and insulin. It also supports the transportation of calcium inside the cell for utilization. Magnesium promotes the normal functioning of muscle and nervous tissue, and the synthesis of all proteins, nucleic acids, nucleotides, fats and carbohydrates.
Magnesium supports the normal release of energy from food during metabolism, regulation of body temperature, proper nerve function and helping the body handle stress. Importantly, magnesium also promotes healthy bones, teeth and normal muscle development. It works together with calcium and vitamin D to promote strong bones. Magnesium, when combined with calcium, helps support the heart muscle in maintaining a regular heartbeat and promoting normal blood pressure.
Potassium (Bicarbonate) (94 mg)
Potassium is an electrolyte stored in the muscles. Foods rich in potassium include bananas, oranges, cantaloupe, avocado, raw spinach, cabbage and celery. Potassium is an essential macromineral that helps maintain fluid balance in the body. It also plays a role in a wide variety of biochemical and physiological processes. Among other things, potassium promotes the transmission of nerve impulses, the contraction of cardiac, skeletal and smooth muscle, the production of energy, the synthesis of nucleic acids and the maintenance of normal blood pressure.
In 1928, it was first suggested that high potassium intake could help maintain cardiovascular health. Potassium promotes normal muscle relaxation and helps maintain normal insulin release. It also promotes glycogen and protein synthesis. Potassium is an electrolyte that promotes normal heartbeat. Potassium promotes the normal release of energy from protein, fat and carbohydrates during metabolism. Potassium helps maintain normal water balance, supports recovery from exercise and the elimination of wastes. Sodium and potassium are two of the most important ions in maintaining the homeostatic equilibrium of the body fluids.
Thiamin HCl (Vitamin B1) (2 mg)
Thiamin promotes normal carbohydrate metabolism and nerve function. Thiamin is required for a healthy nervous system, and supports the production of certain neurotransmitters which have an important role in muscle function. It supports the digestive process, increases energy and helps promote mental clarity.
D-Calcium Pantothenate (Vitamin B5) (20 mg)
Pantothenic acid (B5) promotes proper neurotransmitter activity in the brain. Pantothenic acid is also known as the anti-stress vitamin because it helps relieve physical and emotional stress, and promotes the secretion of hormones essential for optimal health.
Niacinamide (Vitamin B3) (20 mg)
Niacin is a water-soluble vitamin necessary for many aspects of health, growth and reproduction. Niacin supports the proper functioning of the digestive system, skin and nerves. It promotes the conversion of food to energy. Niacin is found in dairy products, poultry, fish, lean meats, nuts, eggs, legumes, and enriched breads and cereals.
Biotin (Vitamin B7) (300 mcg)
Biotin can be found in food sources, such as egg yolks, peanuts, beef liver, milk, cereals, almonds and Brewer’s yeast. Biotin promotes healthy cell growth, the production of fatty acids, metabolism of fats and amino acids. It supports the citric acid cycle, which is the process in which energy is generated during exercise. Biotin is also helpful in maintaining steady blood sugar levels. Biotin is often recommended for maintaining strong hair and nails.
These 10 ingredients, combined with the superior delivery of Isotonix®, create a powerhouse B vitamin product superior to the rest on the market. Isotonix Activated B-Complex delivers all of the B vitamins along with select minerals and electrolytes to help boost energy, decrease stress, improve mood, and much more. The activated forms of select vitamins ensure maximal utilization by the body for optimal results.
nutraMetrix Isotonix Magnesium
Magnesium (Citrate & Glycinate) 400 mg
Magnesium is a component of the mineralized part of bone and supports the normal metabolism of potassium and calcium in adults. It helps maintain normal levels of potassium, phosphorus, calcium, adrenaline and insulin. It also promotes the normal mobilization of calcium, transporting it inside the cell for further utilization. It plays a key role in supporting the normal functioning of muscle and nervous tissue.
Magnesium promotes the normal synthesis of all proteins, nucleic acids, nucleotides, cyclic adenosine monophosphate, lipids and carbohydrates. Magnesium is required for release of energy and it promotes the normal regulation of body temperature and proper nerve function, it helps the body handle stress, and it promotes a healthy metabolism. Magnesium works together with calcium to help maintain the normal regulation of the heart and blood pressure. Importantly, magnesium also supports the body’s ability to build healthy bones and teeth, and promotes proper muscle development. It works together with calcium and vitamin D to help keep bones strong. Magnesium also promotes cardiovascular health by supporting normal platelet activity and helping to maintain normal cholesterol levels.
Potassium (Bicarbonate) 150 mg
Potassium is an electrolyte stored in the muscles. Foods rich in potassium include bananas, oranges, cantaloupe, avocado, raw spinach, cabbage and celery. Potassium is an essential macromineral that helps maintain fluid balance in the body. It also supports a wide variety of biochemical and physiological processes.
Among other things, potassium supports the normal transmission of nerve impulses, contraction of cardiac, skeletal and smooth muscle, synthesis of nucleic acids, maintenance of intracellular tonicity and maintenance of normal blood pressure. In 1928, it was first suggested that high potassium intake could help maintain cardiovascular health. Potassium supports normal muscle relaxation and insulin release. It also promotes glycogen and protein synthesis. Potassium is an electrolyte that promotes normal heartbeat. Potassium supports the body’s ability to regulate water balance, recover from exercise and eliminate wastes.
nutraMetrix Isotonix Turn Up
Potassium (Bicarbonate): 335 mg
Potassium is an electrolyte stored in the muscles. Foods rich in potassium include bananas, oranges, cantaloupe, avocado, raw spinach, cabbage and celery. Potassium is an essential macromineral that helps maintain fluid balance in the body. It also supports a wide variety of biochemical and physiological processes. Among other things, potassium supports the normal transmission of nerve impulses, contraction of cardiac, skeletal and smooth muscle, synthesis of nucleic acids, maintenance of intracellular tonicity and maintenance of normal blood pressure.
In 1928, it was first suggested that high potassium intake could help maintain cardiovascular health. Potassium supports normal muscle relaxation and insulin release. It also promotes glycogen and protein synthesis. Potassium is an electrolyte that promotes normal heartbeat and supports the body’s ability to regulate water balance, recover from exercise and eliminate wastes.
Açai Fruit Pulp: 200 mg/Açai Extract: 100 mg
The açai berry has been harvested from the depths of the rainforests of Brazil by the people who have been using it for thousands of years. Açai berries contain thiamin (B1), niacin (B2), riboflavin (B3), vitamin E, vitamin C, phosphorus, calcium, potassium, fiber, proteins and fatty acids such as Omega 6 and Omega 9.
Açai berries contain high levels of antioxidants, with studies showing higher antioxidant properties than red wine grapes. The dense pigmentation of açaí has led to several experimental studies of its anthocyanins, a group of polyphenols that give the deep color to fruits and vegetables and are high in antioxidant value.
Magnesium (Citrate & Glycinate): 200 mg
Magnesium is a component of the mineralized part of bone and supports the normal metabolism of potassium and calcium in adults. It helps maintain normal levels of potassium, phosphorus, calcium, adrenaline and insulin. It also promotes the normal mobilization of calcium, transporting it inside the cell for further utilization. It supports the normal functioning of muscle and nervous tissue. Magnesium promotes the normal synthesis of proteins, nucleic acids, nucleotides, cyclic adenosine monophosphate, lipids and carbohydrates.
Magnesium is required for release of energy and it promotes the normal regulation of body temperature and proper nerve function, it helps the body handle stress, and it promotes a healthy metabolism. Magnesium works together with calcium to help maintain normal blood pressure. Importantly, magnesium also supports the body’s ability to build healthy bones and teeth, and promotes proper muscle development. It works together with calcium and vitamin D to help keep bones strong. Magnesium also promotes cardiovascular health by supporting normal platelet activity and helping to maintain normal cholesterol levels.
L-Phenylalanine: 200 mg
L-Phenylalanine is an essential amino acid. Amino acids are the building blocks of protein. The body cannot produce L-phenylalanine so it must be obtained through diet or supplementation. The main dietary sources of L-phenylalanine are high protein foods such as meat, fish, eggs and dairy products. Sugar-free products containing the artificial sweetener aspartame (NutraSweet), which is composed of a combination of phenylalanine with another amino acid – aspartic acid, may also be a significant dietary source of L-Phenylalanine. Amino acids come in two forms, designated as L- and D- forms. The L- form is the naturally occurring form in foods, whereas the D- form is the synthetic variety.
L-phenylalanine acts as an amino acid precursor boosting noradrenalin production, which in turn increases mental alertness. L-phenylalanine helps to provide steady energy throughout the day, without the crash that typically follows the consumption of energy products with high sugar content.
L-phenylalanine is an electrically-neutral amino acid, one of the 20 common amino acids used to biochemically form proteins and enzymes, coded by our DNA. L-phenylalanine is necessary for living organisms, including the human body. L-phenylalanine can be converted into L-tyrosine, another of the 20 protein-forming amino acids. L-tyrosine is converted into L-DOPA, which is further converted into dopamine, norepinephrine and epinephrine (latter three are known as the catecholamines).
Vitamin B6, folic acid and vitamin C are needed in order to convert phenylalanine into noradrenaline. Noradrenalin is the brain’s natural energy source, promoting alertness, mental energy and focus.
Guarana Extract: 160 mg
Guarana extract is derived from the seeds of the South American guarana shrub (Paullinia cupana), most of which originates in Brazil. Traditional uses of guarana by natives of the Amazon Rainforest include mixing crushed seeds in foods and beverages to promote alertness, mental energy and focus. As a dietary supplement, guarana is an effective energy booster, as it contains about twice the caffeine found in coffee beans (about three to four percent caffeine in guarana seeds compared to one to two percent for coffee beans). Guarana may enhance mental performance. The seeds of guarana are known to contain xanthines (caffeine) and have been widely used as a tonic in many South American countries, particularly Brazil. In studies, which have determined the total xanthine content of guarana powder, caffeine content typically averages 30 to 50 percent (depending on the extract). Related compounds such as theobromine and theophylline are found at levels of (one to three percent). Most of the scientific evidence on caffeine as a general stimulant and an aid to exercise performance shows convincingly that caffeine is effective.
L-Taurine: 125 mg
L-Taurine is a building block for all the other amino acids. It aids in the transport of potassium, sodium, calcium and magnesium in and out of cells, thus supporting the normal generation of nerve impulses. It is a non-protein amino acid and is found in high amounts in the brain, retina, myocardium, skeletal and smooth muscle, platelets and neutrophils. It is plentiful in the fluids of muscle, lungs and nerve tissue. Dietary taurine mainly comes from animal food sources. Taurine is also present, in lower levels, in plant food sources like seaweed. It is classified as an essential amino acid and promotes normal micelle formation and fat absorption. Further, it promotes alertness, mental energy and focus. Taurine also has antioxidant. It may also help maintain a healthy cardiovascular system and support detoxifying activities.
Mangosteen Powder: 100 mg
The mangosteen is an evergreen tree about 10 to 25 meters tall, grown in tropical climates such as Asia, South America and Polynesia. Mangosteen fruit is often called the “Queen of Fruits” due to its pleasant flavor. The mangosteen fruit is round with slightly flattened ends and is about six to seven centimeters in diameter. It has a smooth, thick, firm rind that is pale green when immature and dark purple or red-purple when ripe. Enclosed by the rind is the edible pulp in four to eight white segments. Each fruit has one to two seeds. The mangosteen fruit contains a compound called xanthones, which is thought to have antioxidant properties. The plant is also a rich source of other bioactive molecules including flavenoids, benzophenones, lactones and phenolic acids. A variety of xanthones can be isolated from the hull, rind, heartwood and flesh of mangosteen plants and fruit. Some studies have demonstrated that the xanthones found in mangosteen have antioxidant properties; six xanthones found in the mangosteen fruit were isolated from the fruit peel.
L-Tyrosine: 100 mg
L-Tyrosine is an amino acid found naturally in our bodies. Tyrosine is metabolized into neurotransmitters such as dopamine, norepinephrine and epinephrine. Neurotransmitters are important because they carry messages from one nerve cell to another, thereby playing a vital role in our muscular and cognitive function. Scientists believe that the main cause of mental fatigue is directly related to decreased levels of dopamine, norepinephrine and other neurotransmitters in the brain. Many scientists believe that tyrosine can help relieve occasional symptoms of mental and physical fatigue.
L-Glycine: 100 mg
Glycine is an important amino acid that supports the body’s synthesis of non-essential amino acids. Glycine is one of the few amino acids that can spare glucose for energy by improving glycogen storage. Glycine is useful in the synthesis of DNA and is readily converted into creatine. The body requires glycine for the maintenance of the central nervous system. In men, glycine plays an essential role in maintaining healthy prostate functions.
Vitamin C: 100 mg
Vitamin C, a water-soluble vitamin that acts as an antioxidant, has been proven to support the normal growth and repair of body tissues, support of cardiovascular health, reduced oxidative stress, and promote cognitive health and performance.
Co-enzyme Q10: 60 mg
Coenzyme Q10 belongs to a family of substances called ubiquinones, and is a fat-soluble, wax-like substance that is part of the respiratory chain. It is synthesized in the cells and is involved in electron transport and energy production in mitochondria where about 95 percent of the total energy required by the human body is generated. In the cellular system, CoQ10 supports the generation of energy from oxygen, in the form of ATP. CoQ10 also exhibits activity as a free radical scavenger and an antioxidant. The antioxidant activity in the mitochondria and cell membranes protects against peroxidation of lipid membranes.
Coenzyme Q10 can be found in spinach, broccoli, nuts, meats and fish. In the body, it is found in highest concentration in the cells of the heart, liver, kidney, spleen and pancreas, which all require vast amounts of energy. Supplementation with CoQ10 may be most beneficial for adults because the levels of CoQ10 in the body tend to peak around the age of twenty and then decline with age.
Pomegranate Extract (40% Ellagiac Acid): 50 mg
One pomegranate delivers 40 percent of an adult's daily vitamin C requirement, and also provides folic acid and antioxidants. Pomegranates are high in polyphenols. The most abundant polyphenols in pomegranate are hydrolysable tannins, particularly punicalagins, which research has shown to be the antioxidant responsible for the free-radical scavenging ability of pomegranate juice.
Many food and dietary supplement makers have found the advantages of using pomegranate extracts (which have no sugar, calories or additives), instead of the juice, as ingredients in their products. Many pomegranate extracts are essentially ellagic acid, which is largely a by-product of the juice extraction process. Ellagic acid has been shown in published studies to absorb into the body when consumed as ellagitannins such as punicalagins.
Yerba Maté Extract: 45 mg
Yerba maté is an evergreen with white flowers and red fruit, found naturally only in South America. The dried or roasted leaves, which contain caffeine, are used in nutritional products. Yerba maté contains xanthines, which are alkaloids in the same family as caffeine, theophylline and theobromine, well-known stimulants also found in coffee and chocolate. Yerba Maté also contains potassium, magnesium and manganese.
Like coffee, Yerba Maté stimulates the central nervous system. It may promote strong heart contractions, heart rhythm, and may support the break down of sugars in the body. It is largely used to fight occasional fatigue. Yerba Maté has been shown to promote alertness, mental energy and focus, without the negative effects typically created by similar compounds. Yerba Maté creates a powerful answer to occasional mental and physical fatigue. Yerba maté is used worldwide as a rejuvenator of energy and mental alertness.
Green Tea: 25 mg
Green tea extract has been used nutritionally for centuries in India and China. A number of beneficial health effects are related to regular consumption of green tea and dried/powdered extracts of green tea that are available in some dietary supplements. Green tea is prepared by picking, lightly steaming and allowing the leaves to dry. The active components in green tea are a family of polyphenols (catechins) and flavonols, which possess potent antioxidant activity. Several catechins are present in major quantities; epicatechin (EC), epigallocatechin (EGC), epicatechin gallate (ECG) and epigallocatechin gallate (EGCG). EGCG makes up around 10 to 50 percent of the total catechin content and appears to be the most powerful of all the catechins, with demonstrated antioxidant activity. Green tea extract is reported to have positive effects including cardiovascular system support.
Green tea contains a substantial amount of antioxidants, including epigallocatechin gallate (EGCG). Green tea’s polyphenolic antioxidants support cardiovascular health, help combat free radicals and support the normal oxidation of LDL cholesterol. Aside from the clear benefits of green tea as an antioxidant, recent studies have suggested green tea may support weight control. ‡This extract is decaffeinated.
L-Carnitine: 20 mg
L-carnitine is an amino acid that is found in nearly all cells of the body. L-carnitine supports fat metabolism in the heart, organs and tissue. L-carnitine occurs naturally in animal products and only very small amounts are found in plants, with a few exceptions, such as avocado and some fermented soy products. It also plays an essential role in the transportation of long chain fatty acids into the mitochondria of the cell, which results in additional energy in the form of adenosine triphosphate (ATP). L-carnitine is synthesized in the body, mainly in the liver and kidneys, from the essential amino acids L-lysine and L-methionine.
Niacinamide: 15 mg NE
Niacin is a water-soluble vitamin that supports many aspects of health, growth and reproduction. Niacin supports the proper functioning of the digestive system, skin and nerves. It promotes the conversion of food to energy. Niacin is found in dairy products, poultry, fish, lean meats, nuts, eggs, legumes, and enriched breads and cereals.
Lipase: 5 mg
Lipase is a fat-digesting enzyme that supports the body’s normal break down of dietary fats into an absorbable form. Lipases, such as human pancreatic lipase, support the normal conversion of triglyceride substrates found in oils from food to monoglycerides and free fatty acids. Some lipases also work within the interior spaces of living cells to support the normal degradation of lipids.
Vitamin B6 (Pyridoxine HCl): 4.1 mg
Poultry, fish, whole grains and bananas are the main dietary sources of vitamin B6. B6 supports normal protein and amino acid metabolism, and helps maintain proper fluid balance. It also assists in the maintenance of healthy red and white blood cells, which supports our overall health. Vitamin B6 promotes normal hemoglobin synthesis (hemoglobin is the protein portion of red blood cells which carries oxygen throughout the body). Because vitamin B6 is involved in the synthesis of neurotransmitters in the brain and nerve cells, it has been recommended as a nutrient to support mental function, specifically mood. Athletic supplements often include vitamin B6 because it promotes the conversion of glycogen to glucose for energy in muscle tissue. Vitamin B6, when taken with folic acid, has been shown to help maintain normal plasma levels of homocysteine, which promotes optimal cardiovascular health. Vitamin B6 should be taken as a part of a complex of other B vitamins for best results.
Pantothenic Acid (d-Calcium Pantothenate): 4 mg
Pantothenic acid promotes proper neurotransmitter activity in the brain. Pantothenic acid is also known as the anti-stress vitamin and it promotes the secretion of hormones essential for optimal health.
Boron: 2 mg
Boron is a mineral found at high levels in plant foods such as dried fruits, nuts, dark green, leafy vegetables, applesauce, grape juice and cooked dried beans and peas. Boron is found in most tissues, but mainly in the bone, spleen and thyroid. Boron supports normal bone and hormone metabolism. Boron supports the body’s ability to build and maintain healthy bones. It also helps the body retain calcium and magnesium to promote proper bone mineralization. Boron is an essential cofactor for the conversion of vitamin D to its active form. It supports the maintenance of healthy cell membranes, proper mental functioning and alertness, and helps maintain normal serum estrogen levels and ionized calcium.
Zinc (Gluconate): 1.3 mg
Zinc is largely found in fortified cereals, red meats, eggs, poultry and certain seafood, including oysters. Zinc is a component of multiple enzymes and proteins. It is also involved in the regulation of gene expression. Zinc is an essential trace mineral that has functions in 300 different enzymatic reactions. Thus, zinc plays a part in almost all biochemical pathways and physiological processes. More than 90 percent of the body’s zinc is stored in the bones (30 percent) and muscles (60 percent), but zinc is also found in virtually all body tissues. Zinc is involved in such a great number of enzymatic processes it has been found to positively affect a large range of physiological functions such as energy production, cognitive function and carbohydrate metabolism. Zinc is an essential amino acid that is involved in many enzymatic reactions in the body, ranging from the synthesis of proteins and collagen, to the production of cellular energy.
Chromium (Arginate, Picolinate): 215 mcg
Chromium arginate is a form of chromium that is bonded with the essential amino acid Arginine. Like chromium picolinate, it too can support normal insulin activity and the metabolism of protein, fat and carbohydrates.
Together with chromium picolinate, chromium arginate helps to support cardiovascular health by helping to maintain normal insulin sensitivity. It also helps maintain healthy blood sugar and cholesterol levels.
Copper (Gluconate): 166 mcg
The richest sources of dietary copper derive from organ meats, seafood, nuts, seeds, wheat bran cereal, whole grain products and cocoa products. Copper has antioxidant properties and acts as a component of enzymes in iron metabolism. It is an essential trace mineral. Copper supports normal infant development, red and white blood cell maturation, iron transport, bone strength, cholesterol metabolism, myocardial contractility, glucose metabolism, brain health and immune function.
Folic Acid: 30 mcg
Folic acid is mainly found in fruits and vegetables. Dark, leafy greens, oranges, orange juice, beans, peas and Brewer’s yeast are the best sources. Folic acid plays a key role by boosting the benefits of B12 supplementation. These two B vitamins join forces and work together to help maintain normal red blood cells. Folic acid assists in the normal utilization of amino acids and proteins, as well as supporting the construction of the material for DNA and RNA synthesis, which is necessary for all bodily functions. Scientific studies have found that when working in tandem with folic acid, B12 is capable of promoting normal homocysteine levels. This works toward supporting a healthy cardiovascular and nervous system.
Vitamin B12 (Cyanocobalamin): 3.6 mcg
Vitamin B12 is a bacterial product naturally found in animal products, especially organ meats, such as liver, with small amounts derived from peanuts and fermented soy products, such as miso and tempeh. It is essential that vegetarians consume a vitamin B12 supplement to maintain optimal health. Vitamin B12, when ingested, is stored in the liver and other tissues for later use. It supports the normal maintenance of cells, especially those of the nervous system, bone marrow and intestinal tract. Vitamin B12 supports normal homocysteine metabolism (homocysteine is an amino acid that is formed within the body). Normal homocysteine levels are important for maintaining cardiovascular health. Folate and B12, in their active coenzyme forms, are both necessary to support the conversion of homocysteine to methionine, thus helping to maintain healthy blood levels of homocysteine.
nutraMetrix Probiotic 10
L. plantarum has been used in the process of fermenting foods for hundreds of years. One of the most amazing capabilities of L. plantarum is its ability to synthesize L-lysine, an essential amino acid. It is able to promote the proper balance of bacteria while preserving vital nutrients, antioxidants and vitamins, thereby promoting a healthy digestive tract. By competing for the nutrients which the harmful bacteria live on, the neutralized unhealthy bacteria are then able to pass harmlessly through the body.
L. acidophilus is one of the most highly studied and widely used probiotic organisms. It is a strain of lactic acid producing, rod-shaped microbes that have numerous benefits for digestive health. L. acidophilus supports the production of vitamin K, lactase and acidolin, acidolphilin, lactocidin and bacteriocin. Multiple human trials report benefits of L. acidophilus for maintaining vaginal health. Due to the multiple functions of this microorganism, scientists have discovered that administering L. acidophilus orally helps maintain the healthy colonization of bacteria within the digestive tract. L. acidophilus has been shown to support digestive functions and the immune system. The lactase that L. acidophilus creates is an enzyme that supports the normal breakdown of lactose into simple sugars.
L. rhamnosus is a strain of probiotics that aids in balancing the gastrointestinal microflora. It is one of the most intensely studied bacteria in the gastrointestinal tract. One of the remarkable things about L. rhamnosus is its ability to tolerate and even thrive in the harsh acidic conditions normally found in the stomach. L. rhamnosus is believed to be of considerable assistance with supporting immune function in healthy adults, particularly in the urinary tract system (acidic condition). Research has shown that L. rhamnosus helps maintain gastric epithelial cell health, supporting the integrity of the stomach lining.
L. salivarius resides in the mouth and small intestine. It has shown to be effective in supporting dental health. L. salivarius has the unique ability to support a healthy gastrointestinal tract, which may also support immune health.
L. casei is a rod-shaped species of Lactobacillus found in milk, cheese and dairy. It is a lactic acid producer, like other species within the Lactobacillus genus, and has been shown to assist in the colonization of beneficial bacteria. L. casei is active in a broad temperature and pH range, and is naturally found in the mouth and intestine of humans. It supports the production of lactase, which supports the normal breakdown of lactose and promotes optimal digestive health.
L. helveticus is a well-studied probiotic strain commonly used in the production of Swiss-type cheeses to enhance flavor. Several beneficial abilities have been reported from studies including the ability to survive in the stomach and to reach the intestine alive, as well as promoting balanced bacteria in the gastrointestinal tract. Other L. helveticus studies have focused on bone mineral density and bone mineral content, calcium and bone metabolism, arterial flexibility and blood pressure.
B. bifidum occurs naturally in humans and promotes gastrointestinal health. In addition to barrier protection, research has shown that B. bifidum help to support the immune system response by promoting normal lymphocyte (immune cells that produce antibodies and destroy the body’s contaminated cells) and phagocyte (cells that protect the body by ingesting harmful toxins and bacteria) activity. B. bifidum is the predominant bacteria strain found in the microflora of breast-fed infants, and is therefore believed to contribute to the gastrointestinal health of breast-fed infants. B. bifidum is also used to fortify certain dairy products, like yogurt.
B. longum is a branched, rod-shaped bacterium that is among the first to colonize the sterile digestive tract of newborn infants. There is evidence that B. longum competes for attachment sites on the intestinal mucosal membrane, promoting the balanced colonization of bacteria. It has a high resistance to gastric acid and shares similar functions as B. bifidum, such as supporting the immune system and providing barrier protection.
B. breve is another branched, rod-shaped bacterium that promotes the health of the gastrointestinal tract. B. breve is also present in vaginal microflora, where it helps support the body’s normal resistance to yeast. The role of B. breve in the digestive tract is to ferment sugars and produce lactic acid, as well as acetic acid. B. breve is like a champion among probiotic bacteria due to its superior ability to metabolize many types of food.
B. infantis is a probiotic bacterium that inhabits the intestine of both infants and adults. According to a P&G Health Sciences Institute study published in the American Journal of Gastroenterology, B. infantis may be beneficial in promoting stomach health and comfort. B. infantis plays an important role in supporting basic digestion, proper metabolism and overall well-being.
nutraMetrix Bliss Anti-Stress Formula
Ashwagandha Root (1.5% Withanolides) Extract: 450 mg
Ashwagandha (Withania somnifera) is an adaptogen with a long history as a reliever of stress among other things. Commonly known as “Indian ginseng”, it is regarded as a tonic that may benefit various areas of health, including cognitive and behavioral health. Research suggests ashwagandha may have calming capabilities among other actions. Studies have shown that Ashwagandha root may mimic GABA (primary inhibitory neurotransmitter that controls functions in your body and mind) activity, which means this herb may have calming effects on the body and help to balance mood. Ashwagandha may also have antioxidant properties as a protector against free radicals. Additionally, ashwagandha may support healthy levels of cortisol.
Passion Flower Extract (3.5% Vitexins): 200 mg
Passiflora incarnata or passionflower possesses health-promoting properties from the leaves, stems and flowers and supports a healthy nervous system. Native Americans used it traditionally to help calm restlessness, as well as a natural aid to subdue nervousness, mood and stress. The main active constituents in passionflower are still contested among researchers, however, research has shown the alkaloids and flavonoids of this herb contribute to its health benefits. Some recent studies suggest flavonoids in passionflower are primarily responsible for its relaxing effects however, more research is needed. One of passionflower’s mechanisms of action may be supporting normal levels of GABA in the brain, which promotes relaxation./p>
Rhodiola rosea Root Extract (3% Salidrosides): 150 mg
“Roseroot” contains a phenylpropanoid glycoside called salidroside/rhodioloside/rhodopsin, which may be responsible for roseroot's relaxation and adaptogenic actions – increasing resistance to the effects of stressors. Animal studies have shown protection from stressors may increase work capacity and decrease occasional fatigue. Roseroot extracts also demonstrate potential for supporting healthy cognitive function, supporting positive energy and mood levels.
Bacopin™† (Bacopa monniera): 150 mg
Bacopin has a long history in promoting health. Traditionally it has been used for promoting cognitive health, such as supporting memory function and mood balance. The main active constituents of Bacopa are saponins, which includes the chemical compounds bacoside A and bacoside B. Bacosides A and B have been shown in research studies to support learning ability, cognitive performance and improve mood. Bacopa also contains the flavonoids, apigenin and luteolin, which studies have found to support cognitive health.
Bacopin™ is a standardized extract prepared from the leaves of the Bacopa monniera plant, standardized for a minimum of 20% bacosides A and B.
†Bacopin™ is a registered trademark of Sabinsa Corporation.
L-Theanine: 100 mg
L-Theanine is the major amino acid found in green tea, historically used for its relaxing effects. Theanine may work for relaxation by promoting normal levels of gamma-aminobutyric acid (GABA), serotonin and dopamine, which are associated with mood regulation. According to research studies, l-theanine does not produce theta brain waves, which are associated with drowsiness.. Theanine has shown to promote alpha brain wave activity, which promotes a “state of alert relaxation,” and may support healthy stress responses.
Eleuthero Root Extract (0.8% Eleutherosides): 100 mg
Eleuthero (Eleutherococcus senticosus) is an adaptogen which historically has been used in helping the body adapt to stress and occasional fatigue. It is also known as Siberian ginseng, however, it is only a relative of ginseng and not a true ginseng. As an adaptogen, eleuthero supports homeostasis, or balance, helping the body to deal with stressful conditions. Eleuthero may support adrenal gland function when the body is under stress. In addition to its effect on stress, Eleuthero may support cognitive function. In studies, it has been proven to support mental acuity. Additionally, eleuthero may promote healthy physical functional capacity and body performance. Eleutherosides are the active compounds found in eleuthero that researchers believe provide many of its health benefits.
Displaying reviews 1 - 4 of 4
- Shop Consultant
Great for my busy brain!
This bundle was the #1 recommendation from my GENE SNP results. Appreciate a kit customized to my genetics. Cannot live without my Magnesium! Life Changing. And I love the convenience of the Turn Up packets. Easy for me to use when on the go & great for me to share with my clients. Favorite Bundle!
Response from Customer Service:
December 9, 2019
Dear Valued Customer,
Thank you for taking the time to leave your thoughts on The Methylator Bundle. We are happy to hear you are pleased with the products.
Thank you again!
The Product Information Team
- Shop Consultant
My favorite kit
I love this kit. Keep me more focused. I have more energy and no brain fog anymore. I share specially the TurnUp with my massage clients before their massages. This helped me to achieve better and quick therapeutic massage results. The combination of high quality nutraceuticals and professional massage therapy brought me more and more satisfied customers. Sometimes my customers just request "could you make that orange color drink for me?" Of course!
Response from Customer Service:
December 2, 2019
Dear Valued Customer,
Thank you for taking the time to leave your thoughts on The Methylator Bundle. We are happy to hear you are pleased with the products.
Thank you again!
The Product Information Team
- Shop Consultant
Makes all the difference for my day
The day is a grind! I often end my day with less energy and more brain clutter than I like. I can't change my day to day demands, but I did find I handle them better with this bundle. I have had gene polymorphism testing so I know i need special B vitamins, what I didn't know was how important probiotics, magnesium and stress botanicals were so my mind and body don't feel overwhelmed
- Shop Consultant
Where has this been my whole life!?! This bundle is the ultimate product selection for my needs. I especially appreciate the convenience of the Turn Up packets to take on the go with me. It's just the perfect combination that helps me with that dragging feeling.