nutraMetrix Prime™ Joint Support Formula by Isotonix® - Single Bottle (45 Servings)

$82.95

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Product info

How nutraMetrix Prime™ Joint Support Formula by Isotonix® Benefits You*

As the body ages, many people experience joint discomfort. One option is to take a joint supplement to help promote overall bone and joint health. When looking at a joint supplement, there are three main ingredients found in most products on the market: glucosamine, chondroitin and methylsulfonylmethane, more commonly referred to as MSM.

The research on both chondroitin and MSM is very controversial. Chondroitin, for instance, has very poor absorption due to its high molecular weight. Also, one of chondroitin’s mechanisms is to increase the hyaluronic acid content of synovial fluid; while the new nutraMetrix Prime Joint Support Formula by Isotonix directly provides hyaluronic acid. Hyaluronic acid plays an important role in tissue hydration, lubrication and cellular function. Likewise, research on MSM is not conclusive. In fact, it takes large quantities of MSM daily (2-6 grams) to make a difference and see effects.

On the other hand, the research behind glucosamine is consistent and its benefits effective. nutraMetrix Prime Joint Support Formula contains glucosamine. An aminomonosaccharide (a combination of the amino acid — glutamine and a sugar — glucose), glucosamine is concentrated in joint cartilage and has been scientifically proven to support healthy joint function and promote the normal production of synovial fluid, which lubricates joints and regenerates cartilage.

The natural aging process affects everyone and proper exercise, sleep and supplementation are essential for healthy living. Prime Joint Support Formula also contains the powerful antioxidant Pycnogenol®, which science has shown help maintain the body’s natural defenses by inhibiting metabolic responses associated with the normal aging process.

How nutraMetrix Prime™ Joint Support Formula by Isotonix® Benefits You*

Primary Benefits of nutraMetrix Prime™ Joint Support Formula by Isotonix®*

Primary Benefits of nutraMetrix Prime™ Joint Support Formula by Isotonix®*
  • Promotes optimal joint health
  • Helps maintain joint comfort
  • Helps maintain healthy joint fluidity and flexibility
  • Promotes normal cartilage synthesis and regeneration
  • Supports normal, healthy levels of COX-2 and 5-LOX
(The source of glucosamine contains shellfish)

Stay Active at Any Age

Product Classifications


Gluten-Free - The finished product contains no detectable gluten (<10ppm gluten)


No Detectable GMOs - The finished product contains no detectable genetically-modified organisms


Isotonic-Capable Drinkable Supplements - Easy-to-swallow supplements in liquid form are immediately available to the body for absorption


Quality Standards - GMP Operations and Standardized Ingredients


Checked For: Heavy Metals, Microbiological Contaminants, Allergens, Residual Solvents, Potency, Purity and Identity

Product Classifications

Isotonix Delivery System

Isotonix Delivery System
Isotonix - the World's Most Advanced Nutraceuticals

Isotonic, which means “same pressure,” bears the same chemical resemblance of the body’s blood, plasma and tears. All fluids in the body have a certain concentration, referred to as osmotic pressure. The body’s common osmotic pressure, which is isotonic, allows a consistent maintenance of body tissues. In order for a substance to be absorbed and used in the body’s metabolism, it must be transported in an isotonic state.

Isotonix dietary supplements are delivered in an isotonic solution. This means that the body has less work to do in obtaining maximum absorption. The isotonic state of the suspension allows nutrients to pass directly into the small intestine and be rapidly absorbed into the bloodstream.With Isotonix products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results.

Key Ingredients

Glucosamine (HCl) 1000 mg
Glucosamine is a molecule that is naturally synthesized in the body from glucose and the amino acid glutamine. Glucosamine is an important constituent of glycosaminoglycans in cartilage matrix and synovial fluid. As our bodies age, we are less able to produce glucosamine, resulting in cartilage that is less flexible and weak. Although the mechanism is currently unclear, studies have shown that glucosamine supplementation can support normal, healthy cartilage cell production to help maintain overall joint health.

Pine Bark Extract (Pycnogenol®) 25 mg
Pycnogenol is a water-soluble flavonoid complex with powerful benefits. Pycnogenol, similar to the proanthocyanins found in grape seeds, is extracted from the bark of the French Maritime Pine tree. It is an essential component of the body’s defense system, and can be triggered from numerous internal and external factors. Pycnogenol has been shown help maintain the body’s natural defenses by inhibiting metabolic responses associated with the normal aging process. Research has shown that Pycnogenol may inhibit the activation of NF-kappa B and AP-1. Pycnogenol supplementation can also promote normal COX-2 and 5-LOX gene expression, and support healthy leukotriene biosynthesis. In addition, studies have shown the ability of Pycnogenol to cross-link collagen fibers and strengthen connective tissue proteins. To learn more about the relationship between Pycnogenol and joint health, follow the link below to read the full text studies.

Hyaluronic Acid (Sodium Hyaluronate) 25 mg
Hyaluronic acid plays an important role in tissue hydration, lubrication and cellular function. Although it is produced naturally by the body, the level of hyaluronic acid diminishes with age, contributing to joint discomfort. It is a key component of cartilage, and is important for skin, joint and eye health. Hyaluronic acid has been shown to help maintain strong, healthy cartilage. It may also enhance synovial fluid production and promote normal healing.

FAQs

1. Are there any people who should not take nutraMetrix Prime™ Joint Support Formula by Isotonix®?
If you are currently taking warfarin (Coumadin®), other anti-platelet/anti-coagulant medications, anti-hypertensive medications, or have an ongoing medical condition, you should consult your physician before using this product. If you have a known allergy to shellfish, do not take this product. Women who are pregnant or nursing should not take this product.

2. How should I take nutraMetri® Prime™ Joint Support Formula by Isotonix®?
On an empty stomach, take two cupfuls daily or as directed by your healthcare professional.

3. What other products should I take with nutraMetrix Prime™ Joint Support Formula by Isotonix® to support my joint health?
nutraMetrix Heart Health™ Essential Omega III is a great pair with nutraMetrix Prime Joint Support Formula, as omega III fatty acids have been shown to support healthy joint lubrication.

4. How often should I take nutraMetrix Prime™ Joint Support Formula by Isotonix®?
This product is most effective when taken daily.

5. How much Pycnogenol is in nutraMetrix Prime™ Joint Support Formula by Isotonix®?
There are 25 milligrams of Pycnogenol in each daily serving.

Science

  • James, C. and Uhl, T. A review of articular cartilage pathology and the use of glucosamine sulfate. Journal of Athletic Training. 36(4): 413-419, 2001.
  • Julovi, S., et al. Inhibition of interleukin-1beta-stimulated production of matrix metalloproteinases by hyaluronan via CD44 in human articular cartilage. Arthritis and Rheumatism. 50(2): 516-525, 2004.
  • Laurent, T., et al. Functions of hyaluronan. Annals of the Rheumatic Disease. 54(5): 429-432, 1995.
  • Nakatani, S., et al. Glucosamine regulates differentiation of a chondrogenic cell line, ATDC5. Biological and Pharmaceutical Bulletin. 30(3): 433-438, 2007.
  • Ohno, S., et al. Hyaluronan oligosaccharides induce matrix metalloproteinase 13 via transcriptional activation of NFkappaB and p38 MAP kinase in articular chondrocytes. Journal of Biological Chemistry. 281(26): 17952-17960, 2006.
  • Poustie, M., et al. N-butyryl glucosamine increases matrix gene expression by chondrocytes. Journal of Pharmacology and Experimental Therapeutics. 311(2): 610-616, 2004.
  • Sasaki, A., et al. Hyaluronate inhibits the interleukin-1beta-induced expression of matrix metalloproteinase (MMP)-1 and MMP-3 in human synovial cells. The Tohoku Journal of Experimental Medicine. 204(2): 99-107, 2004.
  • Schäfer, A., et al. Inhibition of COX-1 and COX-2 activity by plasma of human volunteers after ingestion of French maritime pine bark extract (Pycnogenol®). Biomedicine and Pharmacotherapy. 60: 5-9, 2006.

*These statements have not been evaluated by the Food and Drug Administration.
This product(s) is not intended to diagnose, treat, cure or prevent any disease.

Reviews

Customer Reviews
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  • (4)
Displaying reviews  1 - 5 of 55

on

  • Shop Consultant

My mom takes it as daily maintenance

My mom takes it as daily maintenance As she has slight trouble getting up and down the stairs these years.

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Response from Customer Service:
October 19, 2026

Thank you so much for sharing your mom’s experience with Prime™ Joint Support Formula by Isotonix®. We’re glad to hear it’s become a helpful part of her daily routine and supports her mobility. Your feedback means a lot to us, and we wish her continued comfort and wellness!

on

  • Shop Consultant

Joint rescue

I just reordered, for sure notice how much it help me when I stopped using. Never again

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Response from Customer Service:
October 13, 2026

That’s a strong endorsement! It’s amazing how you truly notice the difference when you stop taking something that helps. Glad to hear nutraMetrix Prime™ Joint Support Formula by Isotonix® is making such a positive impact for you—and that you won’t go without it again! Thanks for sharing your experience.

on

  • Shop Consultant

Disappointed

You're very good at taking my money but terrible at delivery. Communication also needs work. Over 2 weeks since you took my money and still no product. When I have it, I do believe it helps me, but now that I'm without for over a week, I'm not happy at all.

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Response from Customer Service:
July 27, 2026

Thank you for taking the time to share your feedback on the Prime™ Joint Support Formula by Isotonix®. We sincerely apologize for the inconvenience and frustration you have experienced with the delivery and communication related to your order.

Your satisfaction is very important to us, and we appreciate you letting us know about your concerns. A Customer Service Representative will be reaching out to you directly to provide assistance and help resolve your issue as quickly as possible.

Thank you again for sharing your experience, and for being a valued customer.

on

  • Shop Consultant

This product is #1

This product helps so much with my movement and joints. You can feel a difference when you don't take it at all....I recommend this one to everyone!

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Response from Customer Service:
June 17, 2026

Thank you so much for your enthusiastic review! We’re delighted to hear that nutraMetrix Prime™ Joint Support Formula by Isotonix® has made a real difference in your routine. Your recommendation means a lot to us, and we truly appreciate you sharing your experience. Thank you for being a valued part of our community!

on

  • Shop Consultant

Love flexibility

At one point, i was walking with a cane, and in continous discomfort. Love the joint support, full flexibility and no discomfort.

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Response from Customer Service:
June 15, 2026

Thank you so much for your wonderful review of Prime™ Joint Support Formula by Isotonix®! We're thrilled to hear it has helped you achieve greater flexibility and improved your daily routine. Your feedback is greatly appreciated. Thank you for being a valued customer!

One or more of the reviews shown may have been posted by a nutraMetrix or SHOP Consultant (An independent distributor of nutraMetrix and Market America products) or a nutraMetrix HP (A health professional who is an independent distributor of nutraMetrix and Market America products).