nutraMetrix Prime™ Joint Support Formula by Isotonix® - Single Bottle (45 Servings)

$82.95

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Product info

How nutraMetrix Prime™ Joint Support Formula by Isotonix® Benefits You*

As the body ages, many people experience joint discomfort. One option is to take a joint supplement to help promote overall bone and joint health. When looking at a joint supplement, there are three main ingredients found in most products on the market: glucosamine, chondroitin and methylsulfonylmethane, more commonly referred to as MSM.

The research on both chondroitin and MSM is very controversial. Chondroitin, for instance, has very poor absorption due to its high molecular weight. Also, one of chondroitin’s mechanisms is to increase the hyaluronic acid content of synovial fluid; while the new nutraMetrix Prime Joint Support Formula by Isotonix directly provides hyaluronic acid. Hyaluronic acid plays an important role in tissue hydration, lubrication and cellular function. Likewise, research on MSM is not conclusive. In fact, it takes large quantities of MSM daily (2-6 grams) to make a difference and see effects.

On the other hand, the research behind glucosamine is consistent and its benefits effective. nutraMetrix Prime Joint Support Formula contains glucosamine. An aminomonosaccharide (a combination of the amino acid — glutamine and a sugar — glucose), glucosamine is concentrated in joint cartilage and has been scientifically proven to support healthy joint function and promote the normal production of synovial fluid, which lubricates joints and regenerates cartilage.

The natural aging process affects everyone and proper exercise, sleep and supplementation are essential for healthy living. Prime Joint Support Formula also contains the powerful antioxidant Pycnogenol®, which science has shown help maintain the body’s natural defenses by inhibiting metabolic responses associated with the normal aging process.

How nutraMetrix Prime™ Joint Support Formula by Isotonix® Benefits You*

Primary Benefits of nutraMetrix Prime™ Joint Support Formula by Isotonix®*

Primary Benefits of nutraMetrix Prime™ Joint Support Formula by Isotonix®*
  • Promotes optimal joint health
  • Helps maintain joint comfort
  • Helps maintain healthy joint fluidity and flexibility
  • Promotes normal cartilage synthesis and regeneration
  • Supports normal, healthy levels of COX-2 and 5-LOX
(The source of glucosamine contains shellfish)

Stay Active at Any Age

Product Classifications


Gluten-Free - The finished product contains no detectable gluten (<10ppm gluten)


No Detectable GMOs - The finished product contains no detectable genetically-modified organisms


Isotonic-Capable Drinkable Supplements - Easy-to-swallow supplements in liquid form are immediately available to the body for absorption


Quality Standards - GMP Operations and Standardized Ingredients


Checked For: Heavy Metals, Microbiological Contaminants, Allergens, Residual Solvents, Potency, Purity and Identity

Product Classifications

Isotonix Delivery System

Isotonix Delivery System
Isotonix - the World's Most Advanced Nutraceuticals

Isotonic, which means “same pressure,” bears the same chemical resemblance of the body’s blood, plasma and tears. All fluids in the body have a certain concentration, referred to as osmotic pressure. The body’s common osmotic pressure, which is isotonic, allows a consistent maintenance of body tissues. In order for a substance to be absorbed and used in the body’s metabolism, it must be transported in an isotonic state.

Isotonix dietary supplements are delivered in an isotonic solution. This means that the body has less work to do in obtaining maximum absorption. The isotonic state of the suspension allows nutrients to pass directly into the small intestine and be rapidly absorbed into the bloodstream.With Isotonix products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results.

Key Ingredients

Glucosamine (HCl) 1000 mg
Glucosamine is a molecule that is naturally synthesized in the body from glucose and the amino acid glutamine. Glucosamine is an important constituent of glycosaminoglycans in cartilage matrix and synovial fluid. As our bodies age, we are less able to produce glucosamine, resulting in cartilage that is less flexible and weak. Although the mechanism is currently unclear, studies have shown that glucosamine supplementation can support normal, healthy cartilage cell production to help maintain overall joint health.

Pine Bark Extract (Pycnogenol®) 25 mg
Pycnogenol is a water-soluble flavonoid complex with powerful benefits. Pycnogenol, similar to the proanthocyanins found in grape seeds, is extracted from the bark of the French Maritime Pine tree. It is an essential component of the body’s defense system, and can be triggered from numerous internal and external factors. Pycnogenol has been shown help maintain the body’s natural defenses by inhibiting metabolic responses associated with the normal aging process. Research has shown that Pycnogenol may inhibit the activation of NF-kappa B and AP-1. Pycnogenol supplementation can also promote normal COX-2 and 5-LOX gene expression, and support healthy leukotriene biosynthesis. In addition, studies have shown the ability of Pycnogenol to cross-link collagen fibers and strengthen connective tissue proteins. To learn more about the relationship between Pycnogenol and joint health, follow the link below to read the full text studies.

Hyaluronic Acid (Sodium Hyaluronate) 25 mg
Hyaluronic acid plays an important role in tissue hydration, lubrication and cellular function. Although it is produced naturally by the body, the level of hyaluronic acid diminishes with age, contributing to joint discomfort. It is a key component of cartilage, and is important for skin, joint and eye health. Hyaluronic acid has been shown to help maintain strong, healthy cartilage. It may also enhance synovial fluid production and promote normal healing.

FAQs

1. Are there any people who should not take nutraMetrix Prime™ Joint Support Formula by Isotonix®?
If you are currently taking warfarin (Coumadin®), other anti-platelet/anti-coagulant medications, anti-hypertensive medications, or have an ongoing medical condition, you should consult your physician before using this product. If you have a known allergy to shellfish, do not take this product. Women who are pregnant or nursing should not take this product.

2. How should I take nutraMetri® Prime™ Joint Support Formula by Isotonix®?
On an empty stomach, take two cupfuls daily or as directed by your healthcare professional.

3. What other products should I take with nutraMetrix Prime™ Joint Support Formula by Isotonix® to support my joint health?
nutraMetrix Heart Health™ Essential Omega III is a great pair with nutraMetrix Prime Joint Support Formula, as omega III fatty acids have been shown to support healthy joint lubrication.

4. How often should I take nutraMetrix Prime™ Joint Support Formula by Isotonix®?
This product is most effective when taken daily.

5. How much Pycnogenol is in nutraMetrix Prime™ Joint Support Formula by Isotonix®?
There are 25 milligrams of Pycnogenol in each daily serving.

Science

  • James, C. and Uhl, T. A review of articular cartilage pathology and the use of glucosamine sulfate. Journal of Athletic Training. 36(4): 413-419, 2001.
  • Julovi, S., et al. Inhibition of interleukin-1beta-stimulated production of matrix metalloproteinases by hyaluronan via CD44 in human articular cartilage. Arthritis and Rheumatism. 50(2): 516-525, 2004.
  • Laurent, T., et al. Functions of hyaluronan. Annals of the Rheumatic Disease. 54(5): 429-432, 1995.
  • Nakatani, S., et al. Glucosamine regulates differentiation of a chondrogenic cell line, ATDC5. Biological and Pharmaceutical Bulletin. 30(3): 433-438, 2007.
  • Ohno, S., et al. Hyaluronan oligosaccharides induce matrix metalloproteinase 13 via transcriptional activation of NFkappaB and p38 MAP kinase in articular chondrocytes. Journal of Biological Chemistry. 281(26): 17952-17960, 2006.
  • Poustie, M., et al. N-butyryl glucosamine increases matrix gene expression by chondrocytes. Journal of Pharmacology and Experimental Therapeutics. 311(2): 610-616, 2004.
  • Sasaki, A., et al. Hyaluronate inhibits the interleukin-1beta-induced expression of matrix metalloproteinase (MMP)-1 and MMP-3 in human synovial cells. The Tohoku Journal of Experimental Medicine. 204(2): 99-107, 2004.
  • Schäfer, A., et al. Inhibition of COX-1 and COX-2 activity by plasma of human volunteers after ingestion of French maritime pine bark extract (Pycnogenol®). Biomedicine and Pharmacotherapy. 60: 5-9, 2006.

*These statements have not been evaluated by the Food and Drug Administration.
This product(s) is not intended to diagnose, treat, cure or prevent any disease.

Reviews

Customer Reviews
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Displaying reviews  1 - 5 of 48

on

Best product out there

Great product works great

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Response from Customer Service:
May 18, 2026

Thank you so much for your positive review of Prime™ Joint Support Formula by Isotonix®! We're thrilled to hear you think it's the best and that it works well for you. Your feedback means a lot to us, and we appreciate your support. Thank you for being a valued customer!

on

Huge shipping delays

Buyer beware: I strongly advise against ordering from this company. I placed a vitamin order on March 28th, and 35 days later (May 2nd), it still hasn’t arrived. This is the third time I’ve experienced significant delays, and the delivery window continues to worsen with every order.

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on

Great Producdt

It works wonderes

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Response from Customer Service:
March 12, 2026

Thank you so much for your wonderful review! We're thrilled to hear that Prime™ Joint Support Formula by Isotonix® has worked so well for you. Your feedback means a lot to us—thank you for being a valued member of our community!

on

Great

Have been taking for over 14 years....It has always worked

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Response from Customer Service:
March 3, 2026

Thank you so much for your wonderful review! We're truly grateful for your loyalty and thrilled to hear that you've been taking Prime™ Joint Support Formula by Isotonix® for over 14 years. Your continued support and trust mean a lot to us—thank you for being such a valued member of our community!

on

Prime Joint

Love it!

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Response from Customer Service:
June 6, 2025

Thank you so much for your enthusiastic review of Prime™ Joint Support Formula by Isotonix®! We're thrilled to hear you’re loving it. Your feedback means a lot to us—thank you for being a valued part of our community!

One or more of the reviews shown may have been posted by a nutraMetrix or SHOP Consultant (An independent distributor of nutraMetrix and Market America products) or a nutraMetrix HP (A health professional who is an independent distributor of nutraMetrix and Market America products).