Primary Benefits of nutraMetrix Isotonix Essentials® Women’s Health*
• Promotes healthy functioning of the skin at a cellular level, which results in health, vibrant-looking skin
• Helps maintain normal cell health
• Helps maintain healthy collagen production
• Provides antioxidant protection for the entire body
• Protects the body from free radicals
• Helps support health bones, teeth, joints and skin
• Helps maintain normal muscle and nerve function
• Supports a healthy immune system
• Supports cardiovascular health
• Promotes cognitive health
• Contains no gluten, wheat, soy, yeast, artificial flavor, salt, preservatives or milk
No Detectable GMOs – the finished product contains no detectable genetically modified organism
Vegetarian – nutraMetrix Isotonix Essentials Women's Health is a vegetarian product
Isotonic-capable Drinkable Supplements – easy-to-swallow supplements in liquid form are immediately available to the body for absorption
Why Choose nutraMetrix Isotonix Essentials® Women’s Health*
As jetsetters and go-getters, women are constantly on the move. There’s a lot to think about all the time, so maintaining a healthy lifestyle can get pushed to the back burner. However, your health should take precedence. Cardiovascular health, skin and bone health are extremely important concerns. Want to take charge of your wellness, but need something to keep up with the super woman lifestyle you’re leading?
Look and feel vibrant with nutraMetrix Isotonix Essentials® Women’s Health custom blend formula. More than a multivitamin, Women’s Health supports a healthy complexion, helps support healthy bones, teeth, joints and skin, and provides antioxidant protection for your entire body. Women will benefit from receiving the foundation of nutrients that deliver vibrancy, while supporting cardiovascular and cognitive health and helping to maintain healthy collagen production.
So while you’re managing life like a champ, let Women’s Health be there to back you up!
Directions For Use
2. Add 8 fl. oz. of water into the cup and stir.
As a dietary supplement, take once daily or as directed by your healthcare provider. Maximum absorption occurs when taken on an empty stomach. This product is isotonic only if the specified amounts of water and powder are used.
Key Ingredients Found in nutraMetrix Isotonix Essentials® Women’s Health*
Calcium is essential for healthy bones and teeth. A sufficient daily calcium intake is necessary for maintaining bone density. Calcium has been shown to reduce symptoms of PMS in women.* Calcium also may play a role in promoting cardiovascular health.
Magnesium works together with calcium to help maintain normal blood pressure. Importantly, magnesium also supports the body’s ability to build healthy bones and teeth, and promotes proper muscle development. It works together with calcium and vitamin D to help keep bones strong. Magnesium also promotes cardiovascular health by supporting normal platelet activity and helping to maintain normal cholesterol levels.*
Magnesium supports the normal release of energy from food during metabolism, regulation of body temperature and proper nerve function. Importantly, magnesium also promotes healthy bones, teeth and normal muscle development. It works together with calcium and vitamin D to promote strong bones. *
Potassium (Bicarbonate): 320 mg
Vitamin E was discovered in the early 1930s. It is available in a natural or synthetic form. In most cases, the natural and synthetic form of vitamins and minerals are identical. However, the natural form of Vitamin E is superior, in terms of absorption and retention in the body.
Vitamin B6 (Pyrodoxine HCl, Pyridoxal-5-Phosphate): 8 mg
Zinc (Lactate): 3.75 mg
Folic acid (folate) must go through a series of chemical conversions before it becomes metabolically active to be properly utilized. Folinic acid is the highly bioavailable, metabolically active derivative of folic acid. It does not require the action of the enzyme dihydrofolinate reductase to become active, so it's not affected by substances and herbs that inhibit this enzyme. Some people have a genetic variation (in the MTHRF gene) that reduces the amount of activated folic acid in the body. Folinic acid, unlike folic acid, is not negatively impacted by this genetic variation.*
Quatrefolic® is the glucosamine salt of (6S)-5-methyltetrahydrofolate, the most active form of folate, as it is structurally analogous to the reduced and active form of folic acid. Because this form is naturally present in the body, it is much more bioavailable for its biological action without having to be metabolized in the body.*
Quatrefolic® is the registered trademark of Gnosis S.p.A. and is protected by U.S. Patent No. 7,947,662.
Taking beta-carotene by mouth along with vitamin C, vitamin E, and zinc daily, seems to support eye health. *
Frequently Asked Questions*
Females 18 years of age and older who want to support healthy skin and body, specific to women’s needs.*
How often should I use nutraMetrix Isotonix Essentials® Women’s Health?
- Magnesium (Glycinate) makes Women’s Health bioavailable and supports cognitive health
- Nutrients in Women’s Health help support collagen production, strong hair and nails*
If you are currently using any prescription drugs, have an ongoing medical condition or are pregnant or breastfeeding, you should consult your healthcare provider before using this product.
These statements have not been evaluated by the Food and Drug Administration. This product(s) is not intended to diagnose, treat, cure or prevent any disease.
Scientific Studies For nutraMetrix Isotonix Essentials® Women’s Health*
• Altura BM and Altura BT. Magnesium and cardiovascular biology: An important link between cardiovascular risk factors and atherogenesis. Cell Mol Biol Res. 41:347-59, 1995.
• Ames, BN, et al. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA 90:7915-7922, 1993.
• Appel LJ. Nonpharmacologic therapies that reduce blood pressure: A fresh perspective. Clin Cardiol. 22:1111-5, 1999.
• Bagchi, D, et al. Cellular protection with proanthocyanidins derived from grape seed. Ann NY Acad Sci 957:260-70, 2002.
• Bagchi, D, et al. Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology 148: 187-97, 2000.
• Bagchi, D, et al. Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro. Res Commun Mol Pathol Pharmacol 95:179-89, 1997.
• Barker J. Insomnia options; natural medicine choices. Townsend Letter for Doctors and Patients. April 2004.
• Bayeta, E., et al. Pycnogenol inhibits generation of inflammatory mediators in macrophages. Nutrition Research 20: 249-259, 2000.
• Benton D., et al. Thiamine supplementation for mood and cognitive functioning. Psychopharmacology. 129(1):66-71, 1997.
• Benton, D., et al. The effects of nutrients on mood. Public Health Nutr. 2(3A):403-409, 1999.
• Bhagavan, H. N., et al. The effect of pyridoxine hydrochloride on blood serotonin and pyridoxal phosphate contents in hyperactive children. Pediatrics. 55(3):437-441, 1975.
• Bilbey, D.L. J., et al. Muscle cramps and magnesium deficiency: case reports. Can Fam Physician. 42:1348-51, 1996.
• Blazsó, G., et al. Anti-inflammatory and superoxide radical scavenging activities of a procyanidins containing extract from the bark of Pinus pinaster Sol. and its fractions. Pharm Pharmacol Lett 3: 217-20, 1994.
• Bodnar L et al. Maternal vitamin D deficiency increases the risk of preeclampsia. Journal of Clinical Endocrinology and Metabolism. 92(9):3517-22, 2007.
• Boyles A et al. Folate and one-carbon metabolism gene polymorphisms and their associations with oral facial clefts. American Journal of Medical Genetics. 146(4):440-9, 2008.
• Brent R et al. Further efforts to reduce the incidence of neural tube defects. Pediatrics. 119(1):225-6, 2007.
• Brilla, L. R., et al. Effect of magnesium supplementation on strength training in humans. J Am Coll Nutr. 11(3):326-329, 1992.
• Bronstrup A, Hages M, Prinz-Langenohl R, Pietrzik K. Effects of folic acid and combinations of folic acid and vitamin B12 on plasma homocysteine concentrations in healthy young women. Am J Clin Nutr 68:1104-10, 1998.
• Brown R. and Gerbarg P. Herbs and nutrients in the treatment of depression, anxiety, insomnia, migraine, and obesity. J Psychiatr Pract. 7(2):75-91, 2001.
• Bryan, J., et al. Associations between dietary intake of folate and vitamins B-12 and B-6 and self-reported cognitive function and psychological well-being in Australian men and women in midlife. J Nutr Health Aging. 8(4):226-232, 2004.
• Bryan, J., et al. Short-term folate, vitamin B-12 or vitamin B-6 supplementation slightly affects memory performance but not mood in women of various ages. Journal of Nutrition. 132(6):1345-1356, 2002.
• Caddell JL. Magnesium deficiency promotes muscle weakness, contributing to the risk of sudden infant death (SIDS) in infants sleeping prone. Magnes Res. 14(1-2):39-50, 2001. Review.
• Candito M et al. Nutritional and genetic determinants of vitamin B and homocysteine metabolisms in neural tube defects: a multicenter case-control study. American Journal of Medical Genetics. 146(9):1128-33, 2008.
• Cao G, Alessio H, Cultler R. Oxygen-radical absorbance capacity assay for antioxidants. Fre Rad Biol & Med 14:301-11, 1993.
• Castillo-Durán C et al. Zinc supplementation and growth of the fetus and low birth weight infant. Journal of Nutrition. 133(5 Suppl 1):1494S-7S, 2003. Review.
• Centers for Disease Control and Prevention (CDC). Prevalence of neural tube defects and folic acid knowledge and consumption--Puerto Rico, 1996-2006. MMWR Morbidity and Mortality Weekly Report. 57(1):10-3, 2008.
• Chappell L et al. Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomized trial. Lancet. 354(9181):810-816, 1999.
• Chappell L et al. Vitamin C and E supplementation in women at risk of preeclampsia is associated with changes in indices of oxidative stress and placental function. American Journal of Obstetrics and Gynecology. 187(3):777-784, 2002.
• Cho, K., et al. Effect of bioflavonoids extracted from the bark of Pinus maritima on proinflammatory cytokine interlukin-1 production in lipopolysaccharide-stimulated RAW 264. 7. Toxicology and Applied Pharmacology 168: 64-71, 2000.
• Cho, K., et al. Inhibition mechanisms of bioflavonoids extracted from the bark of Pinus maritima on the expression of proinflammatory cytokines. Annals of the NY Academy of Sciences 928: 141-156, 2001.
• Chollet D et al. Blood and brain magnesium in inbred mice and their correlation with sleep quality. Am J Physiol Regul Integr Comp Physiol. 279(6):R2173-8, 2000.
• Coetzee E et al. A randomized controlled trial of intravenous magnesium sulphate versus placebo in the management of women with severe pre-clampsia. British Journal of Obstetrics and Gynecology. 105(3):300, 1998.
• Coppen, A., et al. Plasma folate and affective morbidity during long-term lithium therapy. Br J Psychiatry. 141:87-89, 1982.
• Corsonello A et al. Serum magnesium levels and cognitive impairment in hospitalized hypertensive patients. Magnes Res. 14(4):273-82, 2001.
• Cummings, P. M., et al. Effect of folic acid and antioxidant vitamins on endothelial dysfunction in patients with coronary artery disease. J Am Coll Cardiol. 36:758-765, 2000.
• Czeizel A et al. Dose-dependent effect of folic acid on the prevention of orofacial clefts. Pediatrics. 104(6):e66, 1999.
• Czeizel A et al. Dose-dependent effect of folic acid on the prevention of orofacial clefts. Pediatrics. 104(6):e66, 1999.
• Czeizel A et al. Maternal use of nutritional supplements during the first month of pregnancy and decreased risk of Down's syndrome: case-control study. Nutrition. 21(6):698-704, 2005.
• Dahle, L. O., et al. The effect of oral magnesium substitution on pregnancy-induced leg cramps. Am J Obstet Gynecol. 173(1):175-180, 1995.
• Demirkaya S et al. A comparative study of magnesium, flunarizine and amitriptyline in the prophylaxis of migraine. J Headache Pain. 1:179-86, 2000.
• Devaraj, S., et al. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37:931-4, 2002.
• Dharmarajan, T. S., et al. Vitamin B12 deficiency. Recognizing subtle symptoms in older adults. Geriatrics. 58(3):30-34, 2003.
• Doshi, S. N., et al. Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering. Circulation. 105(1):22-26, 2002.
• Drew B, Leeuwenburgh C. Aging and the role of reactive nitrogen species. Ann NY Acad Sci 959:66-81, 2002.
• Duthie, S. J., et al. Homocysteine, B vitamin status, and cognitive function in the elderly. American Journal of Clinical Nutrition. 75(5):908-913, 2002.
• Elisaf M, Milionis H, Siamopoulos K. Hypomagnesemic hypokalemia and hypocalcemia: Clinical and laboratory characteristics. Mineral Electrolyte Metab. 23:105-12, 1997.
• Fine, AM, Oligomeric proanthocyanidin complexes: history, structure, and phytopharmaceutical applications. Altern Med Rev 5:144-51, 2000.
• Fitzpatrick, D., et al. Endothelium-dependent vascular effects of Pycnogenol. Journal of Cardiovascular Pharmacology 32: 509-515, 1998.
• Frankel, E., et al. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 341: 454-7, 1993.
• Freedman, J., et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 103:2792-8, 2001.
• Frémont, L. Biological effects of resveratrol. Life Sciences 66: 663-673, 2000.
• Friso, S., et al. Low plasma vitamin B-6 concentrations and modulation of coronary artery disease risk. Am J Clin Nutr. 79(6):992-998, 2004.
• Gibson, L, et al. Effectiveness of cranberry juice in preventing urinary tract infections in long-term care facility patients. J Naturopathic Med 2:45-47, 1991.
• Goh Y et al. Prenatal multivitamin supplementation and rates of congenital anomalies: a meta-analysis. Journal of Obstetrics and Gynecology Canada. 28(8):680-9, 2006. Review.
• Goh Y et al. Prenatal supplementation with multivitamins and the incidence of pediatric cancers: clinical and methodological considerations. Pediatrics Blood and Cancer. 50(2 Suppl):487-9; discussion 498, 2008. Review.
• Graham DY, Smith JL, Bouvet, AA. What happens to tablets in the stomach. J Pharm Sci 79:420-24, 1990.
• Grant W et al. Benefits and requirements of vitamin D for optimal health: a review. Alternative Medicine Review. 10(2):94-111, 2005.
• Grant, J. E., et al. Analysis of dietary intake and selected nutrient concentrations in patients with chronic fatigue syndrome. J Am Diet Assoc. 96(4):383-386, 1996.
• Gruber H et al. Magnesium deficiency: effect on bone mineral density in the mouse appendicular skeleton. BMC Musculoskelet Disord. 4(1):7, 2003.
• Gulati, O. Pycnogenol ® in venous disorders: a review. European Bulletin of Drug Research 7: 1-13, 1999.
• Gupta P et al. Multimicronutrient supplementation for undernourished pregnant women and the birth size of their offspring: a double-blind, randomized, placebo-controlled trial. Archives of Pediatric and Adolescent Medicine. 161(1):58-64, 2007.
• Guran T et al. Cognitive and psychosocial development in children with familial hypomagnesaemia. Magnes Res. 24(1):7-12, 2011.
• Halpern, MJ, et al. Red wine polyphenols and inhibition of platelet aggregation: possible mechanisms, and potential use in health promotion and disease prevention. J Int Med Res 26:171-80, 1998.
• Hartvig, P., et al. Pyridoxine effect on synthesis rate of serotonin in the monkey brain measured with position emission tomography. Neural Trans. 102:91-97, 1995.
• Havsteen B. Flavonoids, a class of natural products of high pharmacological potency. Biochem Pharm 32:1141-48, 1983.
• Heap, L. C., et al. Vitamin B status in patients with chronic fatigue syndrome. J R Soc Med. 92(4):183-185, 1999.
• Hernandez-Diaz S et al. Risk of gestational hypertension in relation to folic acid supplementation during pregnancy. American Journal of Epidemiology. 156(9):806-812, 2002.
• Heseker, H., et al. Psychological disorders as early symptoms of a mild-to-moderate vitamin deficiency. Ann N Y Acad Sci. 669:352-357, 1992.
• Hofmeyr G et al. Calcium supplementation to prevent pre-eclampsia--a systematic review. South African Medical Journal. 93(3):224-228, 2003.
• Hollis B. Vitamin D requirement during pregnancy and lactation. Journal of Bone and Mineral Research. 22 Suppl 2:V39-44, 2007. Review.
• Hornyak M et al. Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome: an open pilot study. Sleep. 21:501-5, 1998.
• Hosseini, S., et al. Pycnogenol ® in the management of asthma. Journal of Medicinal Food 4: 201-209, 2001.
• Houston M. The role of magnesium in hypertension and cardiovascular disease. J Clin Hypertens (Greenwich). 13(11):843-7, 2011. Review.
• Huerta MG, Roemmich JN, Kington ML, et al. Magnesium deficiency is associated with insulin resistance in obese children. Diabetes Care. 28:1175-81, 2005.
• Huskisson E et al. The influence of micronutrients on cognitive function and performance. J Int Med Res. 35(1):1-19, 2007. Review.
• Hypponen E. Vitamin D for the prevention of preeclampsia? A hypothesis. Nutrition Reviews. 63(7):225-232, 2005.
• Inna Slutsky et al. Enhancement of Learning and Memory by Elevating Brain Magnesium. Neuron. 65(2):165-77, 2010.
• Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes: Calcium, Phosphorus, Magnesium, Vitamin D and Fluoride. National Academy Press. Washington, DC, 1999.
• Jacobson, W., et al. Serum folate and chronic fatigue syndrome. Neurology. 43:2645-2647, 1993.
• Jee SH et al. The effect of magnesium supplementation on blood pressure: a meta-analysis of randomized clinical trials. Am J Hypertens. 15:691-6, 2002.
• Joseph JA, Shukitt-Hale B, Denisova NA, Bielinksi D, Martin A, McEwen JJ, Bickford PC. Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. J Neuroscience 19: 8114-21, 1999.
• Kaiser L et al. Position of the American Dietetic Association: nutrition and lifestyle for a healthy pregnancy outcome. Journal of the American Dietetic Association. 108(3):553-61, 2008.
• Kay CD, Holub BJ. The effect of wild blueberry (Vaccinium angustifolium) on post-prandial serum antioxidant status in human subjects. Br J Nutr 88: 389-98, 2002.
• Kehrer JP. Free radicals as mediators of tissue injury and disease. Crit Rev Toxicol 23:21-48, 1993.
• Kelly, G. S. Nutritional and botanical interventions to assist with the adaptation to stress. Alternative Medicine Review.4(4):249-265, 1999.
• Khosh, F. Natural approach to hypertension. Alternative Medicine Review. 6(6), 2001.
• Klenner F et al. Observations on the dose and administration of ascorbic acid when employed beyond the range of a vitamin in human pathology. Journal of Applied Nutrition. 23(3-4), 1971.
• Kobrin SM and Goldfarb S. Magnesium Deficiency. Semin Nephrol. 10:525-35, 1990.
• Koch R. Comparative study of Venostatin and Pycnogenol in chronic venous insufficiency. Phytother Res 16:S1-5, 2002.
• Kohama, T., et al. Analgesic efficacy of French maritime pine bark extract in dysmenorrhea. Journal of Reproductive Medicine 49: 828-32, 2004.
• Kohama, T., et al. The treatment of gynecological disorders with Pycnogenol ® . European Bulletin of Drug Research 7: 30-32, 1999.
• Koparker AD, Augsburger LL, Shangraw RF. Intrinsic dissolution rates of tablet fillers and binders and their influence on the dissolution of drugs from tablet formulations. Pharm Res 7:80-85, 1990.
• Lindsey L et al. Understanding optimal nutrition among women of childbearing age in the United States and Puerto Rico: employing formative research to lay the foundation for national birth defects prevention campaigns. Journal of Health Communication. 12(8):733-57, 2007.
• Litoff, D., et al. Effects of pantothenic acid supplementation on human exercise. Med Sci Sport Exercise., 17(Supplement):287, 1985.
• Liu, X., et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 75:2505-13, 2004.
• Liu, X., et al. French maritime pine bark extract pycnogenol dose-dependently lowers glucose in type 2 diabetic patients. Diabetes Care 27: 839, 2004.
• Locksmith G et al. Preventing neural tube defects: the importance periconceptional folic acid supplements. Obstetrics and Gynecology. 321(7):1027-1034, 1998.
• Lopez-Ridaura R et al. Magnesium intake and risk of type 2 diabetes in men and women. Diabetes Care. 27:134-40, 2004.
• Maizels, M., et al. A combination of riboflavin, magnesium, and feverfew for migraine prophylaxis: a randomized trial. Headache. 44(9):885-90, 2004.
• Manna, S., et al. Resveratrol suppresses TNF-Induced activation of nuclear transcription factors NF-kB, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. The Journal of Immunology 164: 6509-19, 2000.
• Maritim, A., et al. Effects of pycnogenol treatment on oxidative stress in streptozotocin-induced diabetic rats. J Biochem Mol Toxicol 17:193-9, 2003.
• Mauskop, A., et al. Role of magnesium in the pathogenesis and treatment of migraines. Clin Neurosci. 5(1):24-27, 1998.
• Mazza G, Kay CD, Cottrell T, Holub BJ. Absorption of anthocyanins from blueberries and serum antioxidant status in human subjects. J Agric Food Chem 50:7731-37, 2002.
• Merialdi M et al. Adding zinc to prenatal iron and folate tablets improves fetal neurobehavioral development. American Journal of Obstetrics and Gynecology. 180(2 Partt 1):483-490, 1999.
• Merialdi M et al. Randomized controlled trial of prenatal zinc supplementation and fetal bone growth. American Journal of Clinical Nutrition. 79(5):826-830, 2004.
• Meyer KA et al. Carbohydrates, dietary fiber, and incident type 2 diabetes in older women. Am J Clin Nutr. 71:921-30, 2000.
• Miyagi, Y., et al. Inhibition of human low-density lipoprotein oxidation by flavonoids in red wine and grape juice. Am J Cardiol 0:1627-31, 1997.
• Mock D et al. Marginal biotin deficiency during normal pregnancy. American Journal of Clinical Nutrition. 75(2):295-299, 2002. · Scholl T et al. Folic acid: influence on the outcome of pregnancy. American Journal of Clinical Nutrition. 71(5 Supplement):1295S-1303S, 2000.
• Monograph. Vaccinium myrtillus (bilberry). Altern Med Rev 6:500-4, 2001.
• Morin P et al. Multivitamin supplement for primary prevention of birth defects: application of a preventive clinical practice. Canadian Family Physician. 53(12):2142-3, 2007.
• Murias M., et al. Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship. 2004.
• Nesaretnam K, et al. Effect of tocotrienols on the growth of a human breast cancer cell line in culture. Lipids 30:1139-43, 1995.
• New SA et al. Nutritional influences on bone mineral density: a cross-sectional study in premenopausal women. Am J Clin Nutr. 65:1831-9, 1997.
• Nuttall SL, Kendall MJ, Bombardelli E, Morazzoni P. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm Ther 23: 385-89, 1998.
• Ofek I, Goldhar J, Zafriri D, Lis H, Sharon N. Anti-Escherichia coli adhesion activity of cranberry and blueberry juices. New England J Med 324:1599, 1991.
• Osada, K., et al. Experimental study of fatigue provoked by biotin deficiency in mice. Int J Vitam Nutr Res. 74(5):334-340, 2004.
• Packer, L., et al. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 27:704-24, 1999. Review.
• Paolisso G et al. Daily magnesium supplements improve glucose handling in elderly subjects. Am J Clin Nutr. 55:1161-7, 1992.
• Pathak P et al. Prevalence of multiple micronutrient deficiencies amongst pregnant women in a rural area of Haryana. Indian Journal of Pediatrics. 71(11):1007-14, 2004. Review.
• Peacock JM et al. Relationship of serum and dietary magnesium to incident hypertension: The Atherosclerosis Risk in Communities (ARIC) Study. Annals of Epidemiology. 9:159-65, 1999.
• Peikert, A., et al. Prophylaxis of migraine with oral magnesium: Results from a prospective, multi-center, placebo-controlled and double-blind randomized study. Cephalalgia. 16(4):257-63, 1996.
• Popoviciu L et al. Clinical, EEG, electromyographic and polysomnographic studies in restless legs syndrome caused by magnesium deficiency (abstract). Rom J Neurol Psychiatry. 31:55-61, 1993.
• Preuss HG, Gondal JA, Lieberman S. Association of macronutrients and energy intake with hypertension. J Am Coll Nutr. 15:21-35, 1996.
• Quadri, P., et al. Homocysteine, folate, and vitamin B-12 in mild cognitive impairment, Alzheimer disease, and vascular dementia. Am J Clin Nutr. 80(1):114-122, 2004.
• Qureshi, A, et al. Response of hypercholesterolemic subjects to administration of tocotrienols. Lipids 30:1171-77, 1995.
• Ren A et al. Comparison of blood folate levels among pregnant Chinese women in areas with high and low prevalence of neural tube defects. Public Health Nutrition. 10(8):762-8, 2007.
• Repke J. Calcium, magnesium, and zinc supplementation and perinatal outcome. Clinical Obstetrics and Gynecology. 34(2):262-7, 1991. Review.
• Riggs, K. M., et al. Relations of vitamin B-12, vitamin B-6, folate, and homocysteine to cognitive performance in the Normative Aging Study. American Journal of Clinical Nutrition. 63(3):306-314, 1996.
• Rimbach G, Virgili F, Park YC, Packer L. Effect of procyanidins from Pinus maritime on glutathione levels in endothelial cells challenged by 3-morpholinosydnonimine or activated macrophages. Redox Rep 4:171-77, 1999.
• Rodriguez-Moran M and Guerrero-Romero F. Oral magnesium supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects. Diabetes Care. 26:1147-52, 2003.
• Roffe, C., et al. Randomised, cross-over, placebo controlled trial of magnesium citrate in the treatment of chronic persistent leg cramps. Med Sci Monit. 8(5):CR326-CR330, 2002.
• Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol ®), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40:158-68, 2002. Review.
• Rohdewald, P. Pycnogenol ®. In “Flavonoids in Health and Disease”. Ed. Catherine Rice-Evans and Lester Packer. New York: Marcel Dekker, Inc., 1998. 405-19.
• Roseff, S., et al. Improvement in sperm quality and function with French maritime pine tree bark extract. Journal Reproductive Medicine 47: 821-4, 2002.
• Roseff, S., et al. Improvement of sperm quality by Pycnogenol ®. European Bulletin of Drug Research 7: 33-6, 1999.
• Rude KR. Magnesium metabolism and deficiency. Endocrinol Metab Clin North Am. 22:377-95, 1993.
• Rude R et al. Magnesium deficiency and osteoporosis: animal and human observations. J Nutr Biochem. 15(12):710-716, 2004.
• Ryan-Harshman M et al. Folic acid and prevention of neural tube defects. Canadian Family Physician. 54(1):36-8, 2008.
• Ryder K et al. Magnesium intake from food and supplements is associated with bone mineral density in healthy older white subjects. J Am Geriatr Soc. 53(11):1875-1880, 2005.
• Saito, M., et al. Antiulcer activity of grape seed extract and procyanidins. J Agric Food Chem 46: 1460-4, 1998.
• Sales CH et al. Influence of magnesium status and magnesium intake on the blood glucose control in patients with type 2 diabetes. Clin Nutr. 30(3):359-64, 2011.
• Sanjuliani AF et al. Effects of magnesium on blood pressure and intracellular ion levels of Brazilian hypertensive patients. Int J Cardiol. 56:177-83, 1996.
• Saris NE, Mervaala E, et al. Magnesium: an update on physiological, clinical, and analytical aspects. Clinica Chimica Acta. 294:1-26, 2000.
• Saris, N.-E. L., et al. Magnesium: an update on physiological, clinical and analytical aspects. Clinica Chimica Acta. 294:1-26, 2000.
• Sato-Mito N et al. The midpoint of sleep is associated with dietary intake and dietary behavior among young Japanese women. Sleep Med. 12(3):289-94, 2011.
• Scholl T et al. Folic acid: influence on the outcome of pregnancy. American Journal of Clinical Nutrition. 71(5 Supplement):1295S-1303S, 2000.
• Scholl T et al. Vitamin E: maternal concentrations are associated with fetal growth. American Journal of Clinical Nutrition. 84(6):1442-8, 2006.
• Scholl T. Maternal nutrition before and during pregnancy. Nestle Nutrition Workshop Series Pediatric Program. 61:79-89, 2008.
• Schönlau, F., et al. Pycnogenol ® for diabetic retinopathy. International Ophthalmology 24: 161-171, 2002.
• Schönlau, F., et al. The cosmeceutical Pycnogenol ®. J Appl Cosmetology 20: 241-6, 2002.
• Segger, D. and Schönlau, F. Supplementation with Evelle ® improves skin smoothness and elasticity in a double blind, placebo-controlled study with 62 women. Journal of Dermatological Treatment 15:222-26, 2004.
• Sharma, S., et al. Pycnogenol ® inhibits the release of histamine from mast cells. Phytotherapy Research 17: 66-69, 2003.
• Shaw G et al. Risks of orofacial clefts in children born to women using multivitamins containing folic acid periconceptionally. Lancet. 346(8972):393-6, 1995.
• Shechter M et al. Effects of oral magnesium therapy on exercise tolerance, exercise-induced chest pain, and quality of life in patients with coronary artery disease. Am J Cardiol. 91:517-21, 2003.
• Shechter M et al. Oral magnesium therapy improves endothelial function in patients with coronary artery disease. Circulation.102:2353-58, 2000.
• Shi, J., et al. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6:291-9, 2003. Review.
• Sinclair, S., et al. Migraine headaches: nutritional, botanical and other alternative approaches. Alternative Medicine Review. 4(2):86-95, 1999.
• Sobota AE. Inhibition of bacterial adherence by cranberry juice: powerfulial use for the treatment of urinary tract infactions. J Urology 131:1013-1016, 1984.
• Soloway MS, Smith RA. J Am Med Assoc 260:1465, 1988.
• Song Y et al. Dietary magnesium intake in relation to plasma insulin levels and risk of type 2 diabetes in women. Diabetes Care. 27:59-65, 2004.
• Spadea, L., et al. Treatment of vascular retinopathies with Pycnogenol ®. Phytotherapy Research 15: 219-23, 2001.
• Stein, J., et al. Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation 100:1050-5, 1999.
• Stendig-Lindberg G et al. Trabecular bone density in a two year controlled trial of peroral magnesium in osteoporosis. Magnes Res. 6:155-63, 1993.
• Suarez L et al. Maternal serum B(12) levels and risk for neural tube defects in a Texas-Mexico border population. Annals of Epidemiology. 13(2):81-88, 2003.
• Svetkey LP et al. Effects of dietary patterns on blood pressure: Subgroup analysis of the Dietary Approaches to Stop Hypertension (DASH) randomized clinical trial. Arch Intern Med. 159:285-93, 1999.
• Takada, Y., et al. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene 23: 9247-58, 2004.
• Tanabe, K., et al. Efficacy of oral magnesium administration on decreased exercise tolerance in a state of chronic sleep deprivation. Jpn Circ J. 62(5):341-346, 1998.
• Tanabe, K., et al. Erythrocyte magnesium and prostaglandin dynamics in chronic sleep deprivation. Clin Cardiol. 20(3):265-268, 1997.
• Tomco, A, et al. Antioxidant effects of tocotrienol in patients with hyperlipidemia and carotid stenosis. Lipids 30: 1179-83, 1995.
• Tranquilli AL et al. Calcium, phosphorus and magnesium intakes correlate with bone mineral content in postmenopausal women. Gynecol Endocrinol. 8:55-8, 1994.
• Trauninger, A., et al. Oral magnesium load test in patients with migraine. Headache. 42(4):114-119, 2002.
• Tucker KL, Hannan MT, Chen H, Cupples LA, Wilson PW, Kiel DP. Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr. 69(4):727-36, 1999.
• Ueda, T., et al. Preventative effect of natural and synthetic antioxidants on lipid peroxidation in the mammalian eye. Ophthalmic Res 28: 184-92, 1996.
• Vaidya A, et al. Effects of antenatal multiple micronutrient supplementation on childrens weight and size at 2 years of age in Nepal: follow-up of a double-blind randomized controlled trial. Lancet. 371(9611):492-9, 2008.
• Van den Berg M., et al. Combined vitamin B-6 plus folic acid therapy in young patients with arteriosclerosis and hyperhomocysteinemia. Journal Vascular Surgery. 20(6):933-940, 1994.
• van Oort FV, Melse-Boonstra A, Brouwer IA, et al. Folic acid and reduction of plasma homocysteine concentrations in older adults: a dose-response study. 77:1318-23, 2003.
• Vargiu, R., et al. Enhancement of muscular performance by a coformulation of propionyl-L-carnitine, coenzyme Q(10), nicotinamide, riboflavin and pantothenic acid in the rat. Physiol Behav. 76(2):257-63, 2002.
• Vormann J. Magnesium: nutrition and metabolism. Molecular Aspects of Medicine. 24:27-37, 2003.
• Wald DS, Bishop L, Wald NJ, et al. Randomized trial of folic acid supplementation and serum homocysteine levels. Arch Intern Med 61:695-700, 2001.
• Wald N et al. Quantifying the effect of folic acid. Lancet. 358(9298):2069-2073, 2001.
• Wallerath, T., et al. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 106:1652-8, 2002.
• Wang, F., et al. Oral magnesium oxide prophylaxis of frequent migrainous headache in children: a randomized, double-blind, placebo-controlled trial. Headache. 43(6):601-610, 2003.
• Watson, R. Pycnogenol ® and cardiovascular health. Evidence-Based Integrative Medicine 1: 27-32, 2003.
• Wei, Z., et al. Pycnogenol enhances endothelial cell antioxidant defense. Redox Report 3: 219-24, 1997.
• Wen S et al. Folic acid supplementation in early second trimester and the risk of preeclampsia. American Journal of Obstetrics and Gynecology. 198(1):45.e1-7, 2008.
• Werbach, M. R. Nutritional strategies for treating chronic fatigue syndrome. Alternative Medicine Review. 5(2):93-108, 2000.
• Wester PO. Magnesium. Am J Clin Nutr. 45:1305-12, 1987.
• Widman L et al. The dose-dependent reduction in blood pressure through administration of magnesium. A double blind placebo controlled cross-over study. Am J Hypertens. 6:41-5, 1993.
• Wilcox A et al. Folic acid supplements and risk of facial clefts: national population based case-control study. British Medical Journal. 334(7591):464, 2007.
• Wilson R et al. Pre-conceptional vitamin/folic acid supplementation 2007: the use of folic acid in combination with a multivitamin supplement for the prevention of neural tube defects and other congenital anomalies. Journal of Obstetrics Gynecology Canada. 29(12):1003-26, 2007.
• Woo, K. S., et al. Long-term improvement in homocysteine levels and arterial endothelial function after 1-year folic acid supplementation. American Journal of Medicine. 112(7):535-539, 2002.
• Woolhouse, M. Migraine and tension headache--a complementary and alternative medicine approach. Aust Fam Physician. 34(8):647-51, 2005. Review.
• Wynn A and Wynn M. Magnesium and other nutrient deficiencies as possible causes of hypertension and low birth weight. Nutrition and Health. 6(2):69-88, 1988. Review.
• Yamakoshi, J., et al. Proanthocyanidin-rich extract from grape seeds attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits. Atherosclerosis 142:139-149, 1999.
• Yu-Yahiro, J. A. Electrolytes and their relationship to normal and abnormal muscle function. Orthop Nurs. 13(5):38-40, 1994.
• Zagré N et al. Prenatal multiple micronutrient supplementation has greater impact on birth weight than supplementation with iron and folic acid: a cluster-randomized, double-blind, controlled programmatic study in rural Niger. Food and Nutrition Bulletin. 28(3):317-27, 2007.
• Zheng W, Wang SY. Oxygen radical absorbing capacity of phenolics in blueberries, cranberries, chokeberries, and lingonberries. J Agric Food Chem 51:502-9, 2003.
Displaying reviews 1 - 5 of 16
I love the convenience, the taste and how well I feel when I take this packet! I take many other Isotonix products, but the ingredients in this packet help me feel energetic, digested and mentally balanced. I like this in a fun glass during quiet time. It's my go to wind down drink!
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For the Woman on the Go!
This complete vitamin pack really packs a punch. It is so much more than a multi-vitamin. With quality trademarked ingredients like Quatrafolic, SunActive and Pycnogelol, it provides me with energy and focus when I just have too much going on. I also love the added hyaluronic acid, so not only do I feel good when I'm running around like crazy, but I look good doing it!
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Great product for overall Women's Health but also to balance and regulate our system. I feel a more sustained energy throughout the day and overall more calm
- Shop Consultant
Great product for busy ladies
My customers love this product for the convenience it brings with the nutrients required to maintain their overall health . Very easy to carry around especially for those who travels a lot and it tastes great!
- Shop Consultant
I love that Isotonix can be added to water and not have to swallow several pills to get all of the supplements I get in this mix made for women!