Product info
How nutraMetrix NAD+ Duo Benefits You*
Support a youthful glow and vibrant health inside and outside with the nutraMetrix NAD+ Duo. This duo pairs our superstar, vitality-enhancing nutraMetrix Prime Anti-Aging Nutraceuticals® NAD+ with our brand-new showstopper nutraMetrix Lumière de Vie® NAD Crème to provide your body with exactly what it needs to fight aging at the cellular level.
Your cells are constantly under siege — environmental toxins, UV exposure, emotional stress, poor sleep, and metabolic strain all chip away at cellular health. This comprehensive duo supports the body's natural repair systems at two critical levels.
nutraMetrix Prime NAD+ provides vital NAD precursors to nourish and strengthen your body, whether you face the natural aging process or demanding fitness, work, and travel schedules. Internally, nicotinamide replenishes NAD+ stores to energize every cell, while pterostilbene, a potent cousin of resveratrol, activates sirtuins, key proteins that regulate DNA integrity, stress resistance, and lifespan pathways linked to calorie restriction.
nutraMetrix Lumière de Vie® NAD Crème provides 5% Myristyl Nicotinate to penetrate the skin barrier, delivering bioavailable NAD+ precursors directly where oxidative stress and UV damage take their toll. Combined with resveratrol, a powerful polyphenol, Myristyl Nicotinate supports collagen integrity, dermal energy metabolism, and the visible reduction in fine lines and skin fatigue.
Independently, these products effectively combat aging with the scientifically proven power of NAD+. Together, they revolutionize your vitality by providing NAD+ in internal and external forms to maximize the age-defying benefits of this essential ingredient.
Primary Benefits of nutraMetrix NAD+ Duo*
Turn Back the Clock Inside & Out
nutraMetrix Prime Anti-Aging Nutraceuticals® NAD+
- Supports healthy NAD+ production
- Helps to maintain neurological and cognitive health as we age
- May help maintain NAD+ levels in aging adults
- May help combat the cellular aging process
nutraMetrix Lumière de Vie® NAD Crème
- Supports a revitalized appearance
- Helps keep the skin hydrated; moisturizes
- Helps support skin firmness and elasticity
- Help reduce the appearance of skin redness
- Helps soothe and care for the skin
- Helps keep the skin looking soft and smooth
One Duo for a Total NAD+ Refresh
nutraMetrix NAD+ Duo is important to life; it fuels cellular energy, supports DNA health and supports cellular metabolism, but levels decline with age, stress, and environmental exposure, leaving you with sluggish energy, dull skin, and a body that doesn’t bounce back like it used to. That’s where the nutraMetrix NAD+ Duo comes in, helping promote NAD+ levels from the inside out. *
Ready to Radiate from Within?
Don’t just fight aging — work with your biology. Get the nutraMetrix NAD+ Duo and give your body a full-spectrum strategy for feeling better, thinking clearer, and looking more radiant. nutraMetrix Lumiere de Vie® NAD Crème and nutraMetrix Prime™ NAD+ are the perfect pair, helping support a natural-looking glow and vibrant health inside and out.
Product Classifications
Gluten-Free - The finished product contains no detectable gluten
No Detectable GMOs - The finished product contains no detectable genetically modified organisms
Vegan - The product is made without any ingredients produced or derived from animals
Paraben-free - This product contains no parabens
Cruelty-free - This product and its ingredients were not tested on animals
Quality Standards - GMP Operations and Standardized Ingredients
Checked for: Heavy metals, microbiological contaminants, allergens, residual solvents, potency, purity and identity
Key Ingredients
nutraMetrix Prime NAD+
Nicotinamide Riboside (crystalline nicotinamide riboside chlride) 250 mg
Nicotinamide adenine dinucleotide (NAD) levels naturally decline as we age, and lower levels have been linked to various health issues and the aging process itself. Nicotinamide riboside (NR) is a form of vitamin B3 that functions as a precursor to NAD. When consumed, NR undergoes a series of biochemical reactions, transforming into nicotinamide mononucleotide (NMN), which the body then readily converts into NAD. NAD is a critical coenzyme found in every cell of the body. Its role is to act as a shuttle bus, carrying electrons between molecules in essential steps for many metabolic processes within the cell, namely ATP production – the energy source fueling various cellular functions.
Pterostilbene 50 mg
Pterostilbene is a naturally occurring compound synthesized in plants. It has a similar structure to the more well-known phenol resveratrol. However, pterostilbene has a longer half-life and the compound has two methoxy groups, giving it a higher bioavailability than resveratrol. Once ingested, it is absorbed into the bloodstream and interacts with various cells and tissues, assisting in several biological pathways. Like resveratrol, pterostilbene has been shown to exhibit antioxidant properties, helping to neutralize harmful free radicals and oxidative stress.
nutraMetrix Lumiere de vie® NAD+ Cream
Myristyl Nicotinate (5%) Myristyl
Myristyl nicotinate has been studied for its benefits in cellular renewal. Results from a 12-week study of use of Myristyl nicotinate by individuals using retinoic acid therapy, showed an increase in skin NAD levels, as well as stratum corneum thickness and epidermal thickness, plus reduced transepidermal water loss compared to placebo formulations.
Ginkgo Biloba Callus Culture Extract
Used in skincare and cosmetics, ginkgo biloba callus culture extract soothes skin redness, helps reduce the appearance of wrinkles, and supports skin moisture.
Resveratrol
Resveratrol is a powerful antioxidant known to support the skin’s natural vitality. Resveratrol is used in skincare for its antioxidant properties and ability to promote skin elasticity with regular use.
FAQs
nutraMetrix Prime Anti-Aging Nutraceuticals® NAD+
1. What are the two factors that play into the concentration of NAD in the cells?
The consumption and synthesis of NAD are two factors that play into the concentration levels of NAD within cells. There are three pathways responsible for maintaining this balance: the Preiss-Handler pathway, the de novo biosynthesis pathway and the salvage pathway. Each of these pathways works in different ways to help the precursor NR, as well as other NAD precursors, convert into NAD for the body’s cells. The NAD precursor NR is specifically linked to the salvage pathway.
2. How does nutraMetrix Prime NAD+ differ from nutraMetrix Heart Health™ Advanced Coenzyme Q10 (Co-Q10) on a cellular level and nutraMetrix Awake® Energy Shot on an energy level?
With age, the body produces less Co-Q10. nutraMetrix Heart Health Advanced Co-Q10 aids in Co-Q10 production, which helps supply energy to every cell of the human body and promotes cardiovascular health. nutraMetrix Awake Energy Shot is formulated with B vitamins and caffeine to provide a quick boost or bump of energy when needed. nutraMetrix Prime NAD+ is not a short-lived type of energy supplement; it’s an energy supplement for cellular health.
3. What are NAD precursors?
Various sources of vitamin B3, including nicotinamide riboside (NR), nicotinic acid (NA), nicotinamide (NAM), nicotinamide mononucleotide (NMN) and tryptophan (Trp), are known as precursors of NAD, meaning they support the production of NAD.
4. What is the goal of nutraMetrix Prime NAD+?
While all our Prime products are crafted to promote healthy aging at every level (including vision health, vascular health, joint health or hormone support), nutraMetrix Prime NAD+ was specifically formulated to help maintain a healthy reservoir of the youthful NAD molecule to help combat the cellular aging process.
nutraMetrix Lumière de Vie® NAD Crème
5. What skin types can use nutraMetrix Lumière de Vie NAD Crème?
nutraMetrix Lumière de Vie NAD Crème is suitable for all skin types, including dry, oily, combination, and sensitive skin; its balanced formula is designed to nourish without feeling heavy or greasy.
6. Can nutraMetrix Lumière de Vie NAD Crème be layered with other skincare products?
Yes! It’s designed to integrate seamlessly into your existing routine. Apply it after serums and before sunscreen in the morning or as your final step in the evening.
7. When can I expect to see visible results?
While individual results may vary, changes in texture, hydration, and elasticity may be noticed within a few weeks of consistent, twice-daily use.
8. Is this product safe for sensitive skin?
The formula is gentle and includes calming ingredients like ginkgo biloba callus culture extract and resveratrol, which help soothe redness. As always, patch testing is recommended for very sensitive skin.
9. Can nutraMetrix Lumière de Vie NAD Crème be used with retinol or other active treatments?
Yes, it can be used along with actives like retinol, AHAs or vitamin C. If using strong actives, apply them first, then follow with nutraMetrix NAD Crème.
Science
- Amjad, S., Nisar, S., Bhat, A. A., Shah, A. R., Frenneaux, M. P., Fakhro, K., Haris, M., Reddy, R., Patay, Z., Baur, J., & Bagga, P. (2021). Role of NAD+ in regulating cellular and metabolic signaling pathways. Molecular metabolism, 49, 101195. https://doi.org/10.1016/j.molmet.2021.101195
- Sharma, A., Chabloz, S., Lapides, R. A., Roider, E., & Ewald, C. Y. (2023). Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan. Nutrients, 15(2), 445.
- Dellinger, R.W., Santos, S.R., Morris, M. et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study. npj Aging Mech Dis 3, 17 (2017). https://doi.org/10.1038/s41514-017-0016-9
- Covarrubias, A. J., Perrone, R., Grozio, A., & Verdin, E. (2021). NAD+ metabolism and its roles in cellular processes during ageing. Nature reviews. Molecular cell biology, 22(2), 119–141. https://doi.org/10.1038/s41580-020-00313-x
- What is NAD+ and Why Is it Important? (n.d.). Elysium Health. https://www.elysiumhealth.com/blogs/aging101/what-is-nad-and-why-is-it-important
- Clement, J., Wong, M., Poljak, A., Sachdev, P., & Braidy, N. (2019). The Plasma NAD+ Metabolome Is Dysregulated in "Normal" Aging. Rejuvenation research, 22(2), 121–130. https://doi.org/10.1089/rej.2018.2077
- Lindberg, S. (2023, May 5). Autophagy: What you need to know. Healthline. https://www.healthline.com/health/autophagy
- Superfoodly, & Superfoodly. (2021). Pterostilbene supplement benefits: Longevity miracle or hoax. Superfoodly https://superfoodly.com/pterostilbene-supplement-benefits-longevity-miracle-or-hoax/
- ProHealth Longevity. Sirtuins and your health: the. ProHealth.com. https://www.prohealth.com/blogs/control-how-you-age/activate-your-sirtuins
- Bsc, M. W. M. C. (2023). What foods are high in NAD. Satia - Health, Wellness, Nutrition. https://satia.com/blog/nad-why-it-matters-and-where-to-find-it
- Belenky P, Racette FG, Bogan KL, McClure JM, Smith JS, Brenner C. Nicotinamide Riboside Promotes Sir2 Silencing and Extends Lifespan via Nrk and Urh1/Pnp1/Meu1 Pathways to NAD. Cell. 2007 May 4;129:473-84.
- Billington RA, Travelli C, Ercolano E, Galli U, Roman CB, Grolla AA, Canonico PL, Condorelli F, Genazzani AA. Characterization of NAD Uptake in Mammalian Cells. THE JOURNAL OF BIOLOGICAL CHEMISTRY. 2008 Mar 7;283(10):6367-74.
- Buonvicino D, Ranieri G, Pittelli M, Lapucci A, Bragliola S, Chiarugi A. SIRT1-dependent restoration of NAD+ homeostasis after increased extracellular NAD+ exposure. Journal of Biological Chemistry. 2021 Jul 1;297(1).
- Christopher R. Martens et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nature Communications volume 9, Article number: 1286 (2018).
- de Ligt M, Bruls YMH, Hansen J, Habets MF, Havekes B, Nascimento EBM, Moonen-Kornips E, Schaart G, Zhang D, van Marken Lichtenbelt W, Schrauwen P, Schrauwen-Hinderling VB, Hesselink MKC Resveratrol and pterostilbene potently modulate autophagy. Scientific Reports. 2021.
- Dellinger RW, Santos SR, Morris M, et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study. NPJ Aging Mech Dis. 2017;3:17.
- Fang, EF, Lautrup, S, Hou, Y, Demarest, TG, Croteau, DL, Mattson, MP, Bohr, VA (2017). NAD+ in Aging: Molecular Mechanisms and Translational Implications. Trends in Molecular Medicine, 23(10), 899-916.
- Martens, C. R., Denman, B. A., Mazzo, M. R., et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults Nature Communications. 2018.
- Massudi, H., Grant, R., Braidy, N., Guest, J., Farnsworth, B., & Guillemin, G. J. (2012). Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PloS one, 7(7), e42357.
- Mendelsohn AR, Larrick JW. The NAD+/PARP1/SIRT1 Axis in Aging. Rejuvenation Res. 2017 Jun;20(3):244-247. doi: 10.1089/rej.2017.1980. PMID: 28537485.
- Nagarajan S, Mohandas S, Ganesan K, Xu B, Ramkumar KM. New insights into dietary pterostilbene: Sources, metabolism, and health promotion effects. Molecules. 2022 Sep 25;27(19):6316.
- Chini CC, Zeidler JD, Kashyap S, Warner G, Chini EN. Evolving concepts in NAD+ metabolism. Cell metabolism. 2021 Jun 1;33(6):1076-87.
- Estrela JM, Ortega A, Mena S, Rodriguez ML, Asensi M. Pterostilbene: biomedical applications. Critical reviews in clinical laboratory sciences. 2013 May 1;50(3):65-78.
Reviews
Customer Reviews
Displaying reviews 1 - 5 of 5
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- Shop Consultant
Perfect Combo!
This is an outstanding combo. The NAD+ gives me the perfect amount of energy and I feel like I am able to quickly recover from my workouts. The NAD Creme is a joy to apply and my skin feels so soft after using it. It is a great base for my make up. I do a lot of skin care parties and I make sure to let people sample this because using it is beyond compare. Works immediately!
on
- Shop Consultant
My product review.
I love NAD. My problem is the price. I think NAD cream is over priced for the size.
Response from Customer Service:
June 2, 2026
Thank you so much for sharing your feedback on the NAD+ DUO. We’re delighted to hear that you love the product. We strive to provide the best quality ingredients, experience, and overall benefits to our customers, both in supplements and skincare. We also do our best to make these products available at the most economical price possible.
Your comments about the NAD cream’s pricing are important to us, and we will inform the Motives team so they’re aware of your concerns. Your input helps us as we continue to improve and better serve you. If you have any other suggestions or questions, please don’t hesitate to reach out. Thank you again for your feedback and support!
on
Not for me
I was very excited to try out this duo and took photos of my face, hands and forearms to compare with photos after 30 days. Alas, probably due to my also taking the Vitamin B Complex, I found that these products irritated my skin, turning my face bright red and prickly feeling for several hours. The extra doses of niacin are just too much for me and I've passed the products on to a friend. I'm sad that I won't get to see any benefits of using the duo! I trust others will have better results.
Response from Customer Service:
January 20, 2026
Thank you for taking the time to share your experience with NAD+ DUO. We’re sorry to hear this product did not meet your expectations. Your feedback is important to us, and we want to ensure your concerns are addressed—a product information specialist will reach out to you directly to further assist. Thank you again for giving our product a try and letting us know about your experience.
on
- Shop Consultant
Love the Duo.
I feel like my skin has been transformed. This product is a must have!
Response from Customer Service:
September 22, 2025
Thank you so much for your glowing review! We’re thrilled to hear that the NAD+ DUO has helped transform your skin and become a “must-have” in your routine. Your kind words mean a lot to us, and we’re so grateful you’ve chosen to share your experience. If you ever have any questions or need product recommendations, we’re always here to help!
on
Love it
I can’t stop using this, cream makes my skin look so soft and smooth
Response from Customer Service:
September 2, 2025
Thank you so much for your wonderful review of NAD+ DUO! We're thrilled to hear that you love using the cream and that it's helping your skin look soft and smooth. Your feedback means a lot to us. Thank you for being a valued member of our community!