nutraMetrix Prime Anti-Aging Nutraceuticals® NAD+ - Single Canister (30 Servings)

$49.95

$ 1.00 (2%) Cashback

This product qualifies for free or reduced cost shipping. Learn More

Save BIG when you buy all three together with Core 3 Health!

Isotonix OPC-3® Prime NAD+ Isotonix® Magnesium

Product info

Primary Benefits


  • Supports healthy NAD+ production
  • Promotes normal activity of SIRT-1 gene
  • Supports healthy mitochondrial function
  • Helps maintain healthy levels of ATP production within the cell
  • May help combat the cellular aging process
  • May help maintain NAD+ levels in aging adults
  • Helps to maintain neurological and cognitive health as we age
  • Supports cellular health
  • Support healthy cellular metabolism
  • Supports healthy cognitive function
  • Powerful antioxidant
  • Protects the body from the negative effects of free radicals
Primary Benefits

Product Classifications


Quality Standards – GMP Operations and Standardized Ingredients

Checked For – Heavy Metals, Microbiological Contaminants, Allergens, Residual Solvents, Potency and Identity

Gluten-Free – The finished product contains no detectible gluten (<10ppm gluten)

No Detectable GMOs – The finished product contains no detectable genetically-modified organisms.

Vegan – The product is made without ingredients produced or derived from animals.



Fountain of Youth


What Makes This Product Unique?


Much like an atom is the foundation of the universe, a cell is the foundation of the human body. In the quest for long life and optimal health, scientists have delved into the intricate world of cellular function, DNA integrity and energy production. One significant compound stands out amongst the rest as being a crucial part of human metabolism and its aging process: nicotinamide adenine dinucleotide (NAD). Whether we are talking about simple bacteria or the complexity of human metabolism, NAD and its metabolic counterpart NADH are what the cell relies on for life.

These compounds hold the key to supporting healthy metabolism and aging. NAD is a coenzyme that is essential for carrying out cellular and metabolic functions, such as maintaining healthy levels of ATP production within the cells, supporting the body’s cellular regeneration process and supporting healthy mitochondrial metabolism. nutraMetrix Prime Anti-Aging Nutraceuticals® NAD+ delivers 250 mg of nicotinamide riboside (NR), paired with 50 mg of pterostilbene, both of which have been scientifically shown to support NAD levels within our cells. NAD is connected to one’s health, youth and quality of life; you simply cannot live without it since it is essential for cellular life. The youth of our cells is associated with our physical and cognitive health and overall well-being. nutraMetrix Prime NAD+ is a powerful gluten-free, non-GMO, cutting-edge formula that works to support healthy NAD production and helps maintain NAD levels in aging adults and adults with demanding fitness, work and travel schedules. If it feels like time is always running against you, it's time to consider your energy reserve and NAD. Whether you are looking to combat the natural age-related decline of NAD levels or support NAD levels for those living NAD-depleting lifestyles, the ultimate goal of nutraMetrix Prime NAD+ is helping you sustain a healthy reservoir of the youthful NAD molecule.

NAD is naturally occurring; it resides in every living cell in the body and has been shown to be strongly linked to keeping one's youth. Various sources of vitamin B3 are known as precursors of NAD, meaning they influence or help build upon the production of NAD. The balance between the consumption and synthesis of NAD plays into the replenishment or concentration levels of NAD within our cells. There are three pathways that are responsible for helping to maintain this balance, with each one working differently to convert NAD precursors into NAD for our cells. nutraMetrix Prime NAD+ is specifically formulated with NR; this precursor is linked to the salvage pathway which plays a unique role in replenishing or restoring the pools of NAD in our cells. NAD, the oxidized form of nicotinamide adenine dinucleotides, and NADH, the reduced form, make up the NAD+/NADH redox ratio, which provides insight as to how well our cells are creating energy or ATP and portrays the current condition of cellular health and metabolism. NAD-depleting lifestyles can negatively impact this ratio, throwing it off balance, and imbalances of this ratio are associated with cellular aging. Consuming more NAD precursors that promote the increase of NAD is the longevity secret for helping to maintain a healthy balance of this ratio.

Younger people naturally have higher levels of NAD pools in their cells. Additionally, observational research shows that older individuals who do not display the same biomarkers of aging as their age group are also correlated with higher pools of NAD. This demonstrates why sufficient levels are correlated with cell youth and longevity. Studies have shown that the body’s natural NAD production begins to first decrease in skin and within the brain as we age, making these precursors of higher importance to help sustain NAD levels. Other cellular pools also are impacted by age and the loss of NAD; such as mitochondria, adipose tissue and muscle- emphasizing that NAD is a crucial part of healthy aging. nutraMetrix Prime NAD+ is formulated with two powerful ingredients, NR and pterostilbene, both of which have scientifically proven their ability to support cellular health. A study analyzing the effects of taking both the precursor NR and pterostilbene for an eight-week period (in which participants were either administered a placebo, a single serving or a double serving of the recommended amount) demonstrated its ability promote an increase of NAD levels. When analyzing concentration of NAD levels in the participants’ blood after four weeks, the study found that the group who took the recommended serving showed a 40% increase and the group who was administered a double serving showed a 90% increase of NAD levels in the blood; the placebo group showed no change. In addition, the levels reported at four weeks remained consistent for both groups who were administered NR and pterostilbene supplementation when measured at 60 days.

While supplementation of NAD precursors is what promotes an extra reserve of NAD, it is NAD itself that really does the heavy lifting and influences all the different working parts of the cell that safeguard you from the inevitable cellular aging process. One influencing factor is the promotion of sirtuins (SIRTs) activity, also known as the “longevity genes.” These genes are enzymes that assist in cellular metabolism and help protect the cells’ state of equilibrium or balance when the cells encounter stress. nutraMetrix Prime NAD+ promotes the normal activity of the SIRT-1 gene, a treasured gene that protects the body from the negative effects of free radicals. SIRT-1 is associated with the anti-aging pathways, longevity and the modulation of a whirlwind of processes including DNA repair, genome maintenance, mitochondrial functioning and cellular metabolism. When our DNA becomes damaged, it can deplete the cell’s NAD levels, leading to a decrease in sirtuin activity. Therefore, stockpiling a healthy savings account of NAD naturally makes it easier for our cells to detoxify and aids in preserving the integrity of our genetic blueprint for optimal health.

While maintaining healthy NAD production promotes healthy sirtuin activity, healthy sirtuin activity helps support the of telomeres. Telomeres are genome-protective caps located at the end of chromosomes: they act like the clear coating at the end of a shoelace string that keeps the shoelace from fraying. These little caps can indicate the age or suggested lifespan of a cell, in which the longer in length the telomere is, the better. Each time your cells divide, the chromosomal telomeres become shortened, and over time they inevitably reach the point where the cell can no longer replicate. Evidence shows that shorter telomeres contain lower NAD levels. Just as NAD levels decrease with age, telomeres naturally shorten with age and both are correlated with the health of the cells and their ability to support the body’s cellular regeneration process. Studies suggest that taking both NR and pterostilbene together can support each other's bioavailability, or their ability to be absorbed by the cells. The bioavailability of pterostilbene is an essential factor that promotes the normal activity of the SIRT-1 gene. Pterostilbene also acts as the golden sword for the aging mind, as the autophagy-influencing antioxidant supports the mediation of SIRT-1 and SIRT-2, which may help maintain neurological and cognitive health. In addition, pterostilbene has been shown to be 60% more bioavailable and has a 91 minute longer half-life than its well-known stilbene counterpart, resveratrol; this means that pterostilbene is actively working in your system to assist the cells for a longer period.

Regardless of age, practicing poor lifestyle habits such as smoking, drinking alcohol, lack of sleep or exercise, unhealthy diets and other factors can have depleting effects on maintaining an optimal reservoir of NAD, making NAD-promoting supplementation beneficial for even those who are considered to be younger than the age when metabolic energy may naturally begin to slow down. NR and pterostilbene offer a treasure trove of benefits for our overall well-being and bring you one step further to helping you hack the aging process. With nutraMetrix Prime NAD+ on your side, “The golden age is before us, not behind us.” You don’t have to wait until you are aged to start caring about aging.

*These statements have not been evaluated by the Food and Drug Administration. This product(s) is not intended to diagnose, treat, cure, or prevent any disease.

Key Ingredients


Key Ingredients

Nicotinamide Riboside (crystalline nicotinamide riboside chloride)
Nicotinamide adenine dinucleotide (NAD) levels naturally decline as we age, and lower levels have been linked to various health issues and the aging process itself. Nicotinamide riboside (NR) is a form of vitamin B3 that functions as a precursor to NAD. When consumed, NR undergoes a series of biochemical reactions, transforming into nicotinamide mononucleotide (NMN), which the body then readily converts into NAD. NAD is a critical coenzyme found in every cell of the body. Its role is to act as a shuttle bus, carrying electrons between molecules in essential steps for many metabolic processes within the cell, namely ATP production – the energy source fueling various cellular functions.

Pterostilbene
Pterostilbene is a naturally occurring compound synthesized in plants. It has a similar structure to the more well-known phenol resveratrol. However, pterostilbene has a longer half-life and the compound has two methoxy groups, giving it a higher bioavailability than resveratrol. Once ingested, it is absorbed into the bloodstream and interacts with various cells and tissues, assisting in several biological pathways. Like resveratrol, pterostilbene has been shown to exhibit antioxidant properties, helping to neutralize harmful free radicals and oxidative stress.

FAQs


  1. What are the directions of use for this product?
    Adults, take 2 capsules every morning with or without food. This supplement is meant to be taken only once a day.

  2. Are there any warnings for this product?
    If you are currently using any prescription drugs or have an ongoing medical condition, consult your healthcare provider before using this product. Do not take this product if you are pregnant or breastfeeding.

  3. What are the two factors that play into the continuous replenishment of NAD in the cells?
    The consumption and synthesis of NAD are two factors that play into the replenishment or concentration levels of NAD within the cells. There are three pathways that are responsible for helping to maintain this balance, known as the Preiss-Handler pathway, de novo biosynthesis pathway and the salvage pathway. Each of these pathways works in different ways to help the precursor NR and other NAD precursors convert into NAD for the body’s cells. The NAD precursor NR is specifically linked to the salvage pathway.

  4. What is NAD+/NADH redox ratio?
    NAD is recognized as the oxidized form of nicotinamide adenine dinucleotides whereas NADH is the reduced form. Overall, the NAD+/NADH redox ratio explains how well the cells are creating energy or ATP, portraying the current condition of cellular health and metabolism. NAD-depleting lifestyles can negatively impact this ratio, throwing it off balance and leading to a decreased ratio which is also associated with age. Consuming more NAD precursors which help support levels of NAD is effective for helping to maintain a healthy balance of this ratio.

  5. What can deplete NAD levels in the body other than aging?
    Regardless of age, young or rough lifestyle habits can contribute to the increased need of NAD. Smoking, alcohol consumption, not exercising, being overweight, getting an inadequate amount of sleep and eating an unhealthy diet are all factors that can lead to NAD depletion.

  6. Is this product vegetarian or vegan?
    This product contains no animal-derived ingredients and is suitable for vegetarians and vegans.

  7. How does nutraMetrix Prime NAD+ differ from nutraMetrix Heart Health™ Advanced Co-Q10 on a cellular level and nutraMetrix Awake® Energy Shot on an energy level?
    With age, the body produces less Co-Q10 naturally; Heart Health Advanced Co-Q10 provides additional Co-Q10 to the body which helps generate energy in every cell of the human body and promotes cardiovascular health. Awake Energy Shot is formulated with B vitamins and caffeine to provide a quick boost or bump of energy when needed. Prime NAD+ is not a short-lived type of energy supplement but an energy supplement for cellular longevity and vitality.

  8. What are NAD precursors?
    Various sources of vitamin B3, including nicotinamide riboside (NR), nicotinic acid (NA), nicotinamide (NAM), nicotinamide mononucleotide (NMN), and tryptophan (Trp), are known as precursors of NAD, meaning they influence or help build upon the production of NAD.

  9. What is the half-life of pterostilbene in comparison to resveratrol?
    Pterostilbene has a much longer half-life (105 minutes) than resveratrol (14 minutes), meaning that pterostilbene is actively working in your system for a longer time.

  10. How do nutraMetrix Prime NAD+ and nutraMetrix Heart Health Advanced Co-Q10 work differently to support cell functioning?
    NAD is the spark that initiates what is called electron-transport chain, which is required to manufacture adenosine triphosphate (ATP) or the energy currency of our cells; it is cellular energy at its core and the spark of human metabolism. Heart Health Advanced Co-Q10 contains coenzyme Q10, which acts as a necessary fuel product to support mitochondrial generation. Co-Q10 safeguards the mitochondria from oxidative stress and helps create a healthy environment for mitochondrial activity. In short, NAD is the literal spark for energy, where Co-Q10 is the fuel.

  11. What are other ways you can promote sirtuin activity?
    Sirtuins are special molecules that are associated with supporting the cells’ lifespan. In addition to NR and pterostilbene, the youthful, antioxidant-rich molecule, sirtuin activity can also be promoted by supplementing with resveratrol and curcumin. Exercise and a decrease in caloric intake have also been shown to be effective ways to naturally increase the activity of sirtuins.

  12. What are telomeres?
    Telomeres are genome-protective caps that are located at the ends of chromosomes and indicate the age or suggested lifespan of a cell, in which the longer the telomere in length, the better. Telomeres are like the clear coating at the end of the shoelace string that keeps the lace from fraying; each time your cells divide, the chromosomal telomeres become shorter. Where maintaining healthy NAD production promotes healthy sirtuin activity, healthy sirtuin activity helps support the regulation of telomeres. Evidence shows that shorter telomeres contain lower NAD Just as NAD levels decrease with age, telomeres naturally shorten with age and both are correlated with the health of the cells and their ability to support the body’s cellular regeneration process.

  13. What is the goal of nutraMetrix Prime NAD+?
    While all our Prime products are crafted to promote healthy aging at every level (including vision health, vascular strength, joint or hormone support), nutraMetrix Prime NAD+ was specifically formulated to help you maintain a healthy reservoir of the youthful NAD molecule to help combat the cellular aging process.

  14. What foods contain NAD precursors or naturally assist in promoting NAD?
    Foods such as broccoli, cabbage, cucumber, avocado and tomato contain the NAD precursor NMN. Other foods containing higher levels of niacin and tryptophan, such as dairy, fish, beef, turkey and green vegetables, also help naturally increase NAD.

  15. How was NAD discovered?
    NAD was discovered over 100 years ago while scientists were doing experiments on fermentation in which yeast cells metabolize sugar and convert it into alcohol. Around twenty years later, scientists successfully separated the components of the yeast cells and discovered the chemical shape of the NAD molecule. In 1958, Jack Preiss and Phillip Handler showed how nicotonic acid is converted to NAD and identified responsible enzymes. The pathway that converts nicotonic acid to NAD is named the Preiss-Handler pathway.

*These statements have not been evaluated by the Food and Drug Administration. This product(s) is not intended to diagnose, treat, cure, or prevent any disease.

Science


  • Amjad, S., Nisar, S., Bhat, A. A., Shah, A. R., Frenneaux, M. P., Fakhro, K., Haris, M., Reddy, R., Patay, Z., Baur, J., & Bagga, P. (2021). Role of NAD+ in regulating cellular and metabolic signaling pathways. Molecular metabolism, 49, 101195. https://doi.org/10.1016/j.molmet.2021.101195 
  • Sharma, A., Chabloz, S., Lapides, R. A., Roider, E., & Ewald, C. Y. (2023). Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan. Nutrients, 15(2), 445. 
  • Dellinger, R.W., Santos, S.R., Morris, M. et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study. npj Aging Mech Dis3, 17 (2017). https://doi.org/10.1038/s41514-017-0016-9 
  • Covarrubias, A. J., Perrone, R., Grozio, A., & Verdin, E. (2021). NAD+ metabolism and its roles in cellular processes during ageing. Nature reviews. Molecular cell biology, 22(2), 119–141. https://doi.org/10.1038/s41580-020-00313-x 
  • What is NAD+ and Why Is it Important? (n.d.). Elysium Health. https://www.elysiumhealth.com/blogs/aging101/what-is-nad-and-why-is-it-important 
  • Clement, J., Wong, M., Poljak, A., Sachdev, P., & Braidy, N. (2019). The Plasma NAD+ Metabolome Is Dysregulated in "Normal" Aging. Rejuvenation research, 22(2), 121–130. https://doi.org/10.1089/rej.2018.2077 
  • Lindberg, S. (2023, May 5). Autophagy: What you need to know. Healthline. https://www.healthline.com/health/autophagy 
  • Superfoodly, & Superfoodly. (2021). Pterostilbene supplement benefits: Longevity miracle or hoax. Superfoodlyhttps://superfoodly.com/pterostilbene-supplement-benefits-longevity-miracle-or-hoax/ 
  • ProHealth Longevity. Sirtuins and your health: the. ProHealth.com. https://www.prohealth.com/blogs/control-how-you-age/activate-your-sirtuins 
  • Bsc, M. W. M. C. (2023). What foods are high in NAD. Satia - Health, Wellness, Nutrition. https://satia.com/blog/nad-why-it-matters-and-where-to-find-it 
  • Belenky P, Racette FG, Bogan KL, McClure JM, Smith JS, Brenner C. Nicotinamide Riboside Promotes Sir2 Silencing and Extends Lifespan via Nrk and Urh1/Pnp1/Meu1 Pathways to NAD. Cell. 2007 May 4;129:473-84. 
  • Billington RA, Travelli C, Ercolano E, Galli U, Roman CB, Grolla AA, Canonico PL, Condorelli F, Genazzani AA. Characterization of NAD Uptake in Mammalian Cells. THE JOURNAL OF BIOLOGICAL CHEMISTRY. 2008 Mar 7;283(10):6367-74. 
  • Buonvicino D, Ranieri G, Pittelli M, Lapucci A, Bragliola S, Chiarugi A. SIRT1-dependent restoration of NAD+ homeostasis after increased extracellular NAD+ exposure. Journal of Biological Chemistry. 2021 Jul 1;297(1). 
  • Christopher R. Martens et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nature Communications volume 9, Article number: 1286 (2018). 
  • de Ligt M, Bruls YMH, Hansen J, Habets MF, Havekes B, Nascimento EBM, Moonen-Kornips E, Schaart G, Zhang D, van Marken Lichtenbelt W, Schrauwen P, Schrauwen-Hinderling VB, Hesselink MKC Resveratrol and pterostilbene potently modulate autophagy. Scientific Reports. 2021. 
  • Dellinger RW, Santos SR, Morris M, et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study. NPJ Aging Mech Dis. 2017;3:17. 
  • Fang, EF, Lautrup, S, Hou, Y, Demarest, TG, Croteau, DL, Mattson, MP, Bohr, VA (2017). NAD+ in Aging: Molecular Mechanisms and Translational Implications. Trends in Molecular Medicine, 23(10), 899-916. 
  • Martens, C. R., Denman, B. A., Mazzo, M. R., et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults Nature Communications. 2018. 
  • Massudi, H., Grant, R., Braidy, N., Guest, J., Farnsworth, B., & Guillemin, G. J. (2012). Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PloS one, 7(7), e42357. 
  • Mendelsohn AR, Larrick JW. The NAD+/PARP1/SIRT1 Axis in Aging. Rejuvenation Res. 2017 Jun;20(3):244-247. doi: 10.1089/rej.2017.1980. PMID: 28537485. 
  • Nagarajan S, Mohandas S, Ganesan K, Xu B, Ramkumar KM. New insights into dietary pterostilbene: Sources, metabolism, and health promotion effects. Molecules. 2022 Sep 25;27(19):6316. 
  • Chini CC, Zeidler JD, Kashyap S, Warner G, Chini EN. Evolving concepts in NAD+ metabolism. Cell metabolism. 2021 Jun 1;33(6):1076-87. 
  • Estrela JM, Ortega A, Mena S, Rodriguez ML, Asensi M. Pterostilbene: biomedical applications. Critical reviews in clinical laboratory sciences. 2013 May 1;50(3):65-78. 

*These statements have not been evaluated by the Food and Drug Administration.
This product(s) is not intended to diagnose, treat, cure or prevent any disease.

Reviews


Customer Reviews
  • (13)
  • (1)
  • (0)
  • (1)
  • (0)

Displaying reviews  1 - 5 of 15

on

  • Shop Consultant

Amazing results

I love the NAD+ because I feel and look younger! It’s a literal miracle!

Response from Customer Service:
April 23, 2024

Dear Valued Customer,

We're happy to hear that you're enjoying the benefits of the Prime Anti-Aging Nutraceuticals® NAD+! Customer satisfaction is our top priority, and we're excited that you're feeling great. If you have any questions or need help, please don't hesitate to contact us. Thank you for choosing our product!

Thank you again,
The Product Information Team

on

  • Shop Consultant

Nad

I love it!

Response from Customer Service:
March 21, 2024

Dear Valued Customer,

Thank you for sharing your feedback! We're thrilled to hear that you love our Prime Anti-Aging Nutraceuticals® NAD+ product. If you have any questions or need further assistance, feel free to reach out to us anytime.

Thank you again,
The Product Information Team

on

  • Shop Consultant

Increased energy

We have been taking this product for less than a month, but I have noticed a slight increase in energy for the rest of the day after I have taken NAD+ at lunchtime. So as we continue the core3 health regimen, we will see about other results!

Response from Customer Service:
January 23, 2024

Dear Valued Customer,

Thank you for sharing your experience with us! We're delighted to hear that you've noticed a boost in energy after incorporating NAD+ into your routine. We understand the importance of maintaining a healthy regimen and we're excited for you to explore further results along your journey with Core3 health. Your satisfaction is our top priority, so please don't hesitate to reach out if you have any questions or need assistance. Wishing you continued success with your health goals!

Thank you again,
The Product Information Team

on

  • Shop Consultant

A Game-Changer

I started using NAD+ Thanksgiving week, and what a difference. I have used both OPC-3 and Magnesium for years, so this made sense to add to my daily supplements. Now after almost 2 months, I noticed that I am achieving the same amount of steps when I power walk in 70 minutes that used to take me at least 90 minutes. W0W! I have also noticed that I feel more intensity in my muscles when I lift weights. Another WOW!

As a Baby Boomer who has been a Certified Personal Trainer for 40 years, I am always aware of my fitness levels, and this blows me away. I'll never be without this product. Thank you.

Response from Customer Service:
January 3, 2024

Dear Valued Customer,

Thank you for your enthusiastic review of our Prime Anti-Aging Nutraceuticals® NAD+! We're thrilled to hear how our product has positively impacted your fitness routine and overall well-being. It's particularly rewarding to know that it has been a game changer for you, a seasoned fitness professional.

We appreciate your trust in our product and your decision to incorporate it into your daily regimen. Your feedback is invaluable to us and to other customers looking to enhance their health and fitness levels.

Thank you once again for your kind words and for choosing Prime Anti-Aging Nutraceuticals® NAD+!

The Product Information Team

on

  • Shop Consultant

My Product Review

I have been using NAD+ for approximately 3 weeks. I feel like the energizer bunny. I have had more energy throughout the day. I am loving this product.

Response from Customer Service:
December 26, 2023

Dear Valued Customer,

Thank you so much for sharing your positive experience with the Prime Anti-Aging Nutraceuticals® NAD+! We're thrilled to hear that you're seeing such significant benefits in your energy levels. Your feedback is greatly appreciated and we're excited to continue providing you with high-quality products that enhance your well-being. Your satisfaction is our top priority.

Thank you again!
The Product Information Team

One or more of the reviews shown may have been posted by a nutraMetrix or SHOP Consultant (An independent distributor of nutraMetrix and Market America products) or a nutraMetrix HP (A health professional who is an independent distributor of nutraMetrix and Market America products).