Key Ingredients Found In nutraMetrix® Prime™ Prostate Defense Formula*
Understanding the prostate: The prostate is a small gland, about the size of a walnut, below the bladder in men. Maintaining a healthy prostate is critical in maintaining reproductive health, quality of life and more.
Saw Palmetto (45% free fatty acids) 640 mg
Saw palmetto is an extract of the fruit of Serenoa repens . It is rich in special fatty acids and has traditionally been used for a variety of indications related to the promotion of prostate health. Research indicates saw palmetto may help to maintain urinary health, including frequency of urination. Saw palmetto appears to inhibit an enzyme known to convert testosterone to dihydrotestosterone (DHT). Some research indicates that saw palmetto also induces programmed cell death (apoptosis) in unhealthy cells. Saw palmetto appears to promote normal lipoxygenase (LOX) and cyclooxygenase (COX) enzyme activity, which promote a normal inflammatory response.
Stinging Nettle Extract (0.8% beta-sitosterol) 300 mg
Stinging nettle or common nettle, Urtica dioica , is a herbaceous perennial flowering plant, native to Europe, Asia, northern Africa and North America. Stinging nettle research suggests that it helps maintain normal levels of 5-alpha-reductase, an enzyme which facilitates the conversion of testosterone to DHT. When taken in combination with saw palmetto, stinging nettle appears to promote urinary tract health.
Plant Sterols (min 40% beta sitosterol) 233 mg Research has shown that supplementing with beta sitosterol helps to maintain optimal prostate size and urinary function. Animal research on prostate health suggests that beta-sitosterol might also promote normal 5-alpha-reductase activity, the enzyme responsible for the conversion of testosterone to DHT. Research suggests beta-sitosterol might help to promote normal prostate cell production and size.
Pumpkin Seed Extract (4:1) 160 mg Pumpkin Seed Extract aids in prostate health by promoting normal urinary flow and helping to maintain bladder comfort.
Leucoselect ® - Grape seed extract (95% polyphenols) 125 mg
Leucoselect is a patented grape seed extract with a well-defined composition supported by numerous clinical studies. Leucoselect contains high levels of polyphenols which are substances that have properties widely recognized to promote health. Leucoselect may help to inhibit mild inflammation associated with the aging process.
Dyer's Woad Extract (15:1) ( Isatis indigotica ) 40 mg
Dyer’s Woad is a flowering plant native to the grasslands and desert zones of the Caucasus, Central Asia to eastern Siberia and Western Asia, but is also now found in southeastern and some parts of Central Europe as well. It has been cultivated throughout Europe, especially in Western and southern Europe, since ancient times. Its active component, indirubin, has been shown to be effective in promoting cell death in unhealthy cells.
Zinc Citrate 20 mg
Zinc helps to maintain healthy cells within the prostate. Within the body, zinc accumulates higher in prostate tissue than in any other soft tissue so supplementation is helpful in maintaining cellular health within the prostate.
The ingredients in this formulation were carefully selected to support prostate health. Working synergistically, each of these play a role in minimizing the negative effects of DHT, promoting healthy cell function, and inhibiting mild inflammation associated with the aging process, all helping to maintain healthy prostate size and function.
Scientific Studies For
• Abdel-Rahman, M. Effect of pumpkin seed ( Cucurbita pepe L.) diets on benign prostatic hyperplasia (BPH): chemical and morphometric evaluation in rats. World Journal of Chemistry. 1(1): 33-40, 2006.
• Al-Shukri, S., et al. Early urodynamic effects of the lipido-sterolic extract of Serenoa repens ® ) in patients with lower urinary tract symptoms due to benign prostatic hyperplasia. Prostate Cancer and Prostatic Diseases. 3(3): 195-199, 2000. (Permixon
• Gordon, A. and Shaughnessy, A. Saw palmetto for prostate disorders. American Family Physician. 67(6): 1281-1283, 2003.
• Habib, F. Serenoa repens : the scientific basis for the treatment of benign prostatic hyperplasia. European Association of Urology. 8(13): 887-893, 2009.
• Hong, H., et al. Affects of pumpkin seed extracted oil supplementation on benign prostatic hyperplasia patients. FASEB Journal. 22. 2008.
• Hong, H., et al. Effects of pumpkin seed oil and saw palmetto oil in Korean men with symptomatic benign prostatic hyperplasia. Nutrition Research and Practice. 3(4): 323-327, 2009.
• Nickel, J., et al. Nutraceuticals in prostate disease: the urologist’s role. Reviews in Urology. 10(3): 192-206, 2008.
• Sokeland, J. Combined sabal and urtica extract compared with finasteride in men with benign prostatic hyperplasia: analysis of prostate volume and therapeutic outcome. British Journal of Urology International. 86: 439-442, 2000.
• Wilt, T., et al. Saw palmetto extracts for treatment of benign prostatic hyperplasia: a systematic review. Journal of the American Journal Association. 280(18): 1604-1609, 1998.
• Wilt, T., et al. Serenoa repens for benign prostatic hyperplasia. (Review) The Cochrane Collaboration. John Willey & Sons, Ltd. 2007.
• Adams, L, et al. Analysis of the interactions of botanical extract combinations against the viability of prostate cancer cell lines. Evidence-based Complementary and Alternative Medicine. 3(1): 117-124, 2006.
• Agarwal, C., et al. Grape seed extract induces apoptotic death of human prostate carcinoma DU145 cells via caspases activation accompanied by dissipation of mitochondrial membrane potential and cytochrome c release. Carcinogenesis. 23(11): 1869-1876, 2002.
• Baron, A., et al. Serenoa repens extract targets mitochondria and activates the intrinsic apoptotic pathway in human prostate cancer cells. British Journal of Urology International. 103(9): 1275-1283, 2009.
• Costello, L. and Franklin, R. Novel role of zinc in the regulation of prostate citrate metabolism and its implications in prostate cancer. Prostate. 35(4): 285-296, 1998.
• Fair, W., et al. Cancer of the prostate: a nutritional disease? Urology. 50(6): 840-848, 1997.
• Platz, E. and Helzisouer, K. Selenium, zinc, and prostate cancer. Epidemiologic Reviews. 23(1): 93-101, 2001.
• Raina, K., et al. Oral grape seed extract inhibits prostate tumor growth and progression in TRAMP mice. Cancer Research. 67(12): 5976-5982, 2007.
• Ravaglia, G., et al. Effect of micronutrient status on natural killer cell immune function in healthy free-living subjects aged >/=90 y. American Journal of Clinical Nutrition. 71(2): 590-598, 2000.
• Rowland, D. and Tai, W. A review of plant-derived and herbal approaches to the treatment of sexual dysfunctions. Journal of Sex and Marital Therapy. 29(3): 185-205, 2003.
• Singh, R., et al. Grape seed extract inhibits advanced human prostate tumor growth and angiogenesis and upregulates insulin-like growth factor binding protein-3. International Journal of Cancer. 108: 733-740, 2004.
• Vayalil, P., et al. Proanthocyanidins from grape seed inhibit expression of matrix metalloproteinases in human prostate carcinoma cells, which is associated with the inhibition of activation of MAPK and NFKB. Carcinogenesis. 25(6): 987-995, 2004.
• Danz, H., et al. Inhibitory activity of tryptanthrin on prostaglandin and leukotriene synthesis. Planta Medica. 68: 875-880, 2002.
• Dardenne, M. Zinc and the immune system. European Journal of Clinical Nutrition. 56 (3): S20-S23, 2002.
• Ho, E., et al. Dietary zinc supplementation inhibits NFkappaB activation and protects against chemically induced diabetes in CD1 mice. 226(2): 103-111, 2001.
• Mocchegiani, E., et al. Zinc, oxidative stress, genetic background and immunosenescence: implications for healthy ageing. Immunity and Ageing. 3:6, 2006.
• Molina, P., et al. Inhibition of leukocyte functions by the alkaloid isaindigotone from Isatis indigotica and some new synthetic derivatives. Journal of Natural Products. 64:1297-1300, 2001.
• Agarwal, C., et al. Fractionation of high molecular weight tannins in grape seed extract and identification of procyanidin B2-3, 3’ –di-O-gallate as a major active constituent causing inhibition and apoptotic death of DU145 human prostate carcinoma cells. Carcinogenesis. 28(7): 1478-1484, 2007.
• Gulcin, I., et al. Antioxidant, antimicrobial, antiulcer, and analgesic activities of nettle (Urtica dioica L.). Journal of Ethnopharmacology. 90: 205-215, 2004.
• Mandal, P., et al. Free-radical-scavenging activity in the inflorescence of European Nettle/sisnu (Urtica dioica L.). Journal of Young Pharmacists. 1(2): 129-135, 2009.
• Mohamed, R., et al. Effect of substituting pumpkin seed protein isolate from casein on serum liver enzymes, lipid profile and antioxidant enzymes in CCI4-intoxicated rats. Advances in Biological Research. 3(1-2):9-15, 2009.
• Xanthopoulou, M., et al. Antioxidant and lipoxygenase inhibitory activities of pumpkin seed extracts. Food Research International. 42(5-6): 641-646, 2009. Clifton, P. Effect of grape seed extract and quercetin on cardiovascular and endothelial parameters in high-risk subjects. Journal of Biomedicine and Biotechnology. 2004(5): 272-278, 2004.
• Lukaski, H. Low dietary zinc decreases erythrocyte carbonic anhydrase activities and impairs cardiorespiratory function in men during exercise. American Journal of Clinical Nutrition. 81(5): 1045-1051, 2005.
• Kwon, Y., et al. Health benefits of traditional corn, beans, and pumpkin: in vitro studies for hyperglycemia and hypertension management. Journal of Medicinal Food. 10(2): 266-275, 2006.
• Zhao, G., et al. The molecular mechanism of protective effects of grape seed proanthocyanidin extract on reperfusion arrhythmias in rats in vivo. Biological & Pharmaceutical Bulletin. 33(5): 759-767, 2010.