Sensoril® Trim/Ashwagandha root extract: 450 mg
Ashwagandha has antioxidant and sedative properties. It has been proven to act as an adaptogen by helping to inhibit occasional fatigue, boost energy, promote emotional well-being and counteract the negative effects of stress. Preliminary evidence suggests ashwagandha helps to regulate stress-induced levels of dopamine receptors in the corpus striatum of the brain. It also appears to promote normal levels of plasma corticosterone, blood urea nitrogen and blood lactic acid. Acting as an adaptogen, ashwagandha reduces stress placed on adrenals to perform, thereby helping to decrease the possibility of adrenal fatigue. Though the exact mechanisms by which ashwagandha works are unknown, one hypothesis is that it functions by way of GABA-mimetic activity which acts independently of GABA receptors. In addition to its adaptogenic properties, ashwagandha may promote normal regulation of thyroid function. It has been shown to promote healthy serum levels of the thyroid hormones triodothyronine (T 3) and thyroxine (T 4), both of which are important in promoting normal metabolism.
Holy Basil: 375 mg
Holy basil has adaptogenic and calming activities. Research shows holy basil may help to promote normal plasma corticosterone levels and hepatic and renal functions, help maintain normal blood glucose levels, and inhibit several other stress related issues. Though the exact mechanism of action is not known, it is believed that much of holy basil's effect on stress comes from its high content of eugenol, caryophyllene and triterpenoic acids, such as ursolic and oleanolic acids. Studies have shown eugenol to be effective at promoting normal cyclooxygenase 2 (COX 2), an enzyme involved with the inflammatory response.
L-Theanine: 200 mg
L-Theanine is an amino acid found in green tea and some mushrooms. Preliminary evidence suggests that l-theanine might induce subjective feelings of tranquility in healthy people. It is believed that l-theanine may work by promoting normal levels of the neurotransmitters GABA (Gamma Amino Butyric Acid) and dopamine in the central nervous system. GABA is the primary inhibitory neurotransmitter which promotes calimg effects at the cellular level. Dopamine aids in the regulation of many functions within the brain in regards to behavior, cognition, sleep, mood, attention and memory, and is often associated with the ‘reward’ or ‘pleasure’ center of the brain.
Passion Flower Extract: 200 mg
Passion flower has sedative and relaxation effects. Some studies have pointed to the flavonoids in passion flower such as apigenin, vitexin and isovitexin as the primary constituents responsible for its effects. Research suggests apigenin can bind to central benzodiazepine receptors in the brain, possibly causing relaxation and helping regulate mood without impairing memory or motor skills.
Bacopin® (Bacopa monniera Leaf): 150 mg
Bacopa monniera, also referred to as brahmi, has a long history of use in Ayurvedic health for memory enhancement, support of learning and mood enhancement. Constituents of bacopa, specifically bacosides A and B, have been shown to support learning ability, cognitive performance and improve mood. Bacopa also contains the flavonoids apigenin and luteolin. Research suggests apigenin can bind to central benzodiazepine receptors in the brain, possibly causing relaxation and helping regulate mood without impairing memory or motor skills.
Rhodiola rosea Root Extract: 150 mg
Rhodiola, or roseroot, acts as an antioxidant and adaptogen, promotes relaxation and mental clarity, and helps to improve mood. Research suggests that salidroside, one of over 30 compounds found in rhodiola, is responsible for its stimulating and adaptogenic effects. Within the brain, rhodiola appears to influence the level, activity and transport of monoamine neurotransmitters, such as dopamine, epinephrine and norepinephrine, and serotonin. Rhodiola has been proposed to promote healthy neurotransmitter levels.
Eleuthero Root (Eleutherococcus senticosus) Extract: 100 mg
Research has shown that eleuthero root, also known as 'Siberian ginseng,' has antioxidant, adaptogenic, sedative, as well as many other effects. As an adaptogen, it helps promote the normal regulation of the endocrine system's response to stressors. The active compounds in eleuthero root, eleutherosides, are believed to stimulate the pituitary-adrenocortical system allowing for more efficient regulation of the stress response and healthy levels of cortisol. Other research suggests that it may help to support feelings of well-being, reduce occasional fatigue, and improve memory and cognitive performance.